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Zinc in PDB 6cki: Co-Crystal Structure of MNK2 in Complex with InhibitorEnzymatic activity of Co-Crystal Structure of MNK2 in Complex with Inhibitor
All present enzymatic activity of Co-Crystal Structure of MNK2 in Complex with Inhibitor:
2.7.11.1; Protein crystallography data
The structure of Co-Crystal Structure of MNK2 in Complex with Inhibitor, PDB code: 6cki
was solved by
Q.Han,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Co-Crystal Structure of MNK2 in Complex with Inhibitor
(pdb code 6cki). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Co-Crystal Structure of MNK2 in Complex with Inhibitor, PDB code: 6cki: Zinc binding site 1 out of 1 in 6ckiGo back to Zinc Binding Sites List in 6cki
Zinc binding site 1 out
of 1 in the Co-Crystal Structure of MNK2 in Complex with Inhibitor
Mono view Stereo pair view
Reference:
S.H.Reich,
P.A.Sprengeler,
G.G.Chiang,
J.R.Appleman,
J.Chen,
J.Clarine,
B.Eam,
J.T.Ernst,
Q.Han,
V.K.Goel,
E.Z.R.Han,
V.Huang,
I.N.J.Hung,
A.Jemison,
K.A.Jessen,
J.Molter,
D.Murphy,
M.Neal,
G.S.Parker,
M.Shaghafi,
S.Sperry,
J.Staunton,
C.R.Stumpf,
P.A.Thompson,
C.Tran,
S.E.Webber,
C.J.Wegerski,
H.Zheng,
K.R.Webster.
Structure-Based Design of Pyridone-Aminal EFT508 Targeting Dysregulated Translation By Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. J. Med. Chem. V. 61 3516 2018.
Page generated: Wed Dec 16 11:36:51 2020
ISSN: ISSN 1520-4804 PubMed: 29526098 DOI: 10.1021/ACS.JMEDCHEM.7B01795 |
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