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Zinc in PDB 6b3w: Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One

Protein crystallography data

The structure of Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One, PDB code: 6b3w was solved by K.S.Gajiwala, A.Brooun, W.Liu, Y.Deng, A.E.Stewart, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 147.34 / 3.05
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 70.778, 115.178, 150.967, 90.00, 102.58, 90.00
R / Rfree (%) n/a / n/a

Other elements in 6b3w:

The structure of Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One also contains other interesting chemical elements:

Chlorine (Cl) 4 atoms

Zinc Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 14;

Binding sites:

The binding sites of Zinc atom in the Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One (pdb code 6b3w). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 14 binding sites of Zinc where determined in the Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One, PDB code: 6b3w:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Zinc binding site 1 out of 14 in 6b3w

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Zinc binding site 1 out of 14 in the Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn701

b:44.7
occ:0.74
SG A:CYS431 2.3 75.8 1.0
NE2 A:HIS422 2.3 71.8 1.0
SG A:CYS420 2.4 57.6 1.0
SG A:CYS427 2.5 74.3 1.0
CE1 A:HIS422 3.0 73.2 1.0
CB A:CYS420 3.3 59.2 1.0
CD2 A:HIS422 3.4 73.2 1.0
ZN A:ZN702 3.5 37.8 0.8
ZN A:ZN703 3.5 47.3 0.8
CB A:CYS431 3.6 76.5 1.0
CB A:CYS427 3.6 78.5 1.0
SG A:CYS440 3.7 52.0 1.0
CA A:CYS427 4.1 79.8 1.0
ND1 A:HIS422 4.2 74.4 1.0
CG A:HIS422 4.4 73.5 1.0
CB A:CYS446 4.4 60.4 1.0
SG A:CYS433 4.6 68.0 1.0
CA A:CYS431 4.7 76.7 1.0
CB A:CYS433 4.7 70.3 1.0
CA A:CYS420 4.8 59.9 1.0
SG A:CYS446 4.8 59.7 1.0
N A:CYS427 4.8 81.9 1.0
CD A:PRO432 5.0 74.7 1.0

Zinc binding site 2 out of 14 in 6b3w

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Zinc binding site 2 out of 14 in the Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn702

b:37.8
occ:0.75
SG A:CYS420 2.4 57.6 1.0
SG A:CYS440 2.4 52.0 1.0
SG A:CYS444 2.5 46.3 1.0
SG A:CYS433 2.6 68.0 1.0
CB A:CYS440 3.1 54.0 1.0
CB A:CYS420 3.3 59.2 1.0
CB A:CYS444 3.3 53.3 1.0
ZN A:ZN701 3.5 44.7 0.7
CA A:CYS440 3.6 54.3 1.0
CB A:CYS433 3.6 70.3 1.0
N A:CYS420 3.8 57.6 1.0
ZN A:ZN703 3.9 47.3 0.8
CA A:CYS420 4.1 59.9 1.0
SG A:CYS446 4.4 59.7 1.0
N A:CYS440 4.6 56.9 1.0
CA A:CYS444 4.6 54.6 1.0
SG A:CYS431 4.6 75.8 1.0
C A:CYS440 4.7 52.8 1.0
N A:GLU441 4.8 52.2 1.0
SG A:CYS427 4.8 74.3 1.0
C A:PRO419 4.8 54.8 1.0
O A:CYS420 4.9 63.4 1.0
C A:CYS420 5.0 62.5 1.0

Zinc binding site 3 out of 14 in 6b3w

Go back to Zinc Binding Sites List in 6b3w
Zinc binding site 3 out of 14 in the Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn703

b:47.3
occ:0.81
SG A:CYS450 2.2 69.9 1.0
SG A:CYS427 2.2 74.3 1.0
SG A:CYS446 2.2 59.7 1.0
SG A:CYS440 2.5 52.0 1.0
CB A:CYS446 3.0 60.4 1.0
CB A:CYS450 3.4 71.7 1.0
CB A:CYS440 3.4 54.0 1.0
CB A:CYS427 3.4 78.5 1.0
ZN A:ZN701 3.5 44.7 0.7
ZN A:ZN702 3.9 37.8 0.8
SG A:CYS420 4.1 57.6 1.0
CA A:CYS446 4.5 62.0 1.0
CB A:ASN452 4.6 62.1 1.0
CA A:CYS450 4.7 72.8 1.0
NE A:ARG453 4.7 55.1 1.0
CA A:CYS427 4.8 79.8 1.0
CA A:CYS440 4.9 54.3 1.0
CG A:ARG453 4.9 57.0 1.0

Zinc binding site 4 out of 14 in 6b3w

Go back to Zinc Binding Sites List in 6b3w
Zinc binding site 4 out of 14 in the Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn704

b:49.2
occ:0.80
SG A:CYS463 2.2 54.3 1.0
SG A:CYS457 2.3 59.8 1.0
SG A:CYS468 2.4 61.3 1.0
SG A:CYS459 2.4 57.3 1.0
CB A:CYS457 3.0 60.6 1.0
CB A:CYS459 3.1 62.2 1.0
CB A:CYS463 3.3 61.1 1.0
CB A:CYS468 3.4 65.0 1.0
ZN A:ZN705 3.4 35.1 0.8
ZN A:ZN706 3.7 27.2 0.7
SG A:CYS477 3.9 44.0 1.0
CA A:CYS463 4.0 65.0 1.0
N A:CYS459 4.3 63.7 1.0
CA A:CYS459 4.4 63.2 1.0
CA A:CYS457 4.4 62.4 1.0
CB A:CYS485 4.4 60.5 1.0
CA A:CYS468 4.5 65.1 1.0
SG A:CYS485 4.6 60.8 1.0
CD A:PRO469 4.8 58.8 1.0
C A:CYS457 4.8 63.3 1.0
SG A:CYS470 4.9 54.5 1.0
N A:CYS463 4.9 67.1 1.0
CB A:CYS470 4.9 56.0 1.0

Zinc binding site 5 out of 14 in 6b3w

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Zinc binding site 5 out of 14 in the Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn705

b:35.1
occ:0.75
SG A:CYS498 2.2 53.7 1.0
SG A:CYS477 2.3 44.0 1.0
SG A:CYS485 2.3 60.8 1.0
SG A:CYS463 2.4 54.3 1.0
CB A:CYS463 3.1 61.1 1.0
CB A:CYS485 3.2 60.5 1.0
ZN A:ZN704 3.4 49.2 0.8
CB A:CYS498 3.5 61.0 1.0
CB A:CYS477 3.6 49.3 1.0
SG A:CYS457 3.8 59.8 1.0
ZN A:ZN706 4.0 27.2 0.7
CA A:CYS498 4.4 62.0 1.0
CB A:ASN500 4.5 49.1 1.0
CA A:CYS463 4.6 65.0 1.0
CB A:ALA487 4.6 63.4 1.0
CA A:CYS485 4.6 60.5 1.0
O A:GLN462 4.7 68.5 1.0
CA A:CYS477 4.9 49.7 1.0
C A:CYS485 4.9 59.9 1.0

Zinc binding site 6 out of 14 in 6b3w

Go back to Zinc Binding Sites List in 6b3w
Zinc binding site 6 out of 14 in the Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn706

b:27.2
occ:0.71
SG A:CYS457 2.1 59.8 1.0
SG A:CYS477 2.2 44.0 1.0
SG A:CYS482 2.3 54.5 1.0
SG A:CYS470 2.4 54.5 1.0
CB A:CYS457 3.2 60.6 1.0
CB A:CYS470 3.3 56.0 1.0
CB A:CYS477 3.3 49.3 1.0
N A:CYS457 3.4 63.5 1.0
CB A:CYS482 3.4 56.3 1.0
CA A:CYS477 3.6 49.7 1.0
ZN A:ZN704 3.7 49.2 0.8
CA A:CYS457 3.9 62.4 1.0
ZN A:ZN705 4.0 35.1 0.8
C A:GLY456 4.3 64.6 1.0
SG A:CYS468 4.4 61.3 1.0
N A:CYS477 4.5 50.2 1.0
O A:CYS457 4.6 63.2 1.0
N A:ASP478 4.6 52.3 1.0
CA A:GLY456 4.6 64.0 1.0
CA A:CYS482 4.6 56.3 1.0
C A:CYS457 4.7 63.3 1.0
SG A:CYS485 4.7 60.8 1.0
C A:CYS477 4.7 51.0 1.0
CA A:CYS470 4.7 56.4 1.0
SG A:CYS463 5.0 54.3 1.0

Zinc binding site 7 out of 14 in 6b3w

Go back to Zinc Binding Sites List in 6b3w
Zinc binding site 7 out of 14 in the Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn707

b:27.6
occ:0.70
ND1 A:HIS285 2.1 60.2 1.0
SG A:CYS277 2.2 50.3 1.0
SG A:CYS274 2.3 44.0 1.0
SG A:CYS282 2.4 50.0 1.0
CG A:HIS285 2.8 61.1 1.0
CB A:HIS285 3.0 64.3 1.0
CE1 A:HIS285 3.1 60.4 1.0
CB A:CYS274 3.3 48.2 1.0
CB A:CYS282 3.3 49.2 1.0
CB A:CYS277 3.9 49.0 1.0
N A:HIS285 3.9 63.1 1.0
CD2 A:HIS285 4.0 59.8 1.0
N A:CYS277 4.0 46.2 1.0
CA A:HIS285 4.0 67.4 1.0
NE2 A:HIS285 4.1 59.9 1.0
CB A:LEU284 4.3 53.5 1.0
CB A:ARG276 4.4 49.4 1.0
C A:LEU284 4.5 57.9 1.0
CA A:CYS277 4.6 45.9 1.0
N A:LEU284 4.7 52.2 1.0
CA A:LEU284 4.7 54.5 1.0
CA A:CYS282 4.8 49.9 1.0
CA A:CYS274 4.8 48.6 1.0
O A:HIS285 4.8 72.5 1.0
C A:ARG276 4.9 48.1 1.0
C A:HIS285 5.0 72.3 1.0

Zinc binding site 8 out of 14 in 6b3w

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Zinc binding site 8 out of 14 in the Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn701

b:58.8
occ:0.65
SG B:CYS427 2.3 79.7 1.0
SG B:CYS446 2.3 61.9 1.0
SG B:CYS450 2.4 74.3 1.0
SG B:CYS440 2.5 61.9 1.0
CB B:CYS446 3.1 62.3 1.0
CB B:CYS427 3.4 82.2 1.0
ZN B:ZN703 3.4 42.5 0.6
CB B:CYS440 3.4 60.0 1.0
CB B:CYS450 3.5 74.8 1.0
ZN B:ZN702 3.6 44.5 0.8
SG B:CYS420 4.0 58.2 1.0
CB B:ASN452 4.6 64.7 1.0
CA B:CYS446 4.6 64.1 1.0
CA B:CYS427 4.7 82.9 1.0
SG B:CYS431 4.8 74.4 1.0
CA B:CYS450 4.9 74.7 1.0
CA B:CYS440 4.9 58.3 1.0
CB B:CYS444 4.9 57.5 1.0
NE B:ARG453 5.0 58.1 1.0
NE2 B:HIS422 5.0 78.0 1.0

Zinc binding site 9 out of 14 in 6b3w

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Zinc binding site 9 out of 14 in the Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn702

b:44.5
occ:0.81
SG B:CYS440 2.4 61.9 1.0
SG B:CYS444 2.4 56.8 1.0
SG B:CYS433 2.4 65.6 1.0
SG B:CYS420 2.6 58.2 1.0
CB B:CYS440 3.0 60.0 1.0
CB B:CYS420 3.2 60.3 1.0
CB B:CYS444 3.3 57.5 1.0
ZN B:ZN703 3.4 42.5 0.6
CB B:CYS433 3.5 69.8 1.0
CA B:CYS440 3.6 58.3 1.0
ZN B:ZN701 3.6 58.8 0.7
N B:CYS420 3.8 60.2 1.0
CA B:CYS420 4.1 62.0 1.0
SG B:CYS446 4.4 61.9 1.0
N B:CYS440 4.5 58.7 1.0
SG B:CYS431 4.5 74.4 1.0
CA B:CYS444 4.6 59.0 1.0
SG B:CYS427 4.7 79.7 1.0
C B:CYS440 4.7 56.7 1.0
N B:GLU441 4.8 55.9 1.0
CA B:CYS433 4.9 70.9 1.0
O B:CYS420 4.9 64.4 1.0
C B:PRO419 4.9 58.5 1.0
C B:CYS420 4.9 64.5 1.0

Zinc binding site 10 out of 14 in 6b3w

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Zinc binding site 10 out of 14 in the Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 10 of Structure of Hs/ACPRC2 in Complex with 5,8-Dichloro-7-(3,5-Dimethyl-1, 2-Oxazol-4-Yl)-2-[(4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl]-3,4-Dihydroisoquinolin-1(2H)-One within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn703

b:42.5
occ:0.59
NE2 B:HIS422 2.2 78.0 1.0
SG B:CYS431 2.3 74.4 1.0
SG B:CYS420 2.4 58.2 1.0
SG B:CYS427 2.5 79.7 1.0
CE1 B:HIS422 3.0 78.0 1.0
CB B:CYS420 3.1 60.3 1.0
CD2 B:HIS422 3.2 77.6 1.0
ZN B:ZN701 3.4 58.8 0.7
ZN B:ZN702 3.4 44.5 0.8
CB B:CYS431 3.7 78.2 1.0
CB B:CYS427 3.8 82.2 1.0
SG B:CYS440 3.9 61.9 1.0
ND1 B:HIS422 4.1 77.5 1.0
CG B:HIS422 4.3 76.7 1.0
CA B:CYS427 4.3 82.9 1.0
CB B:CYS446 4.4 62.3 1.0
SG B:CYS433 4.5 65.6 1.0
CA B:CYS420 4.5 62.0 1.0
CA B:CYS431 4.7 78.4 1.0
SG B:CYS446 4.7 61.9 1.0
CD B:PRO432 4.7 74.2 1.0
CB B:CYS433 4.8 69.8 1.0
C B:CYS420 4.9 64.5 1.0

Reference:

P.P.Kung, P.Bingham, A.Brooun, M.Collins, Y.L.Deng, D.Dinh, C.Fan, K.S.Gajiwala, R.Grantner, H.J.Gukasyan, W.Hu, B.Huang, R.Kania, S.E.Kephart, C.Krivacic, R.A.Kumpf, P.Khamphavong, M.Kraus, W.Liu, K.A.Maegley, L.Nguyen, S.Ren, D.Richter, R.A.Rollins, N.Sach, S.Sharma, J.Sherrill, J.Spangler, A.E.Stewart, S.Sutton, S.Uryu, D.Verhelle, H.Wang, S.Wang, M.Wythes, S.Xin, S.Yamazaki, H.Zhu, J.Zhu, L.Zehnder, M.Edwards. Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(Methoxy(Oxetan-3-Yl)Methyl) -2-((4-Methoxy-6-Methyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl)-3,4-Dihydroisoquinolin-1(2H)-One (Pf-06821497). J. Med. Chem. V. 61 650 2018.
ISSN: ISSN 1520-4804
PubMed: 29211475
DOI: 10.1021/ACS.JMEDCHEM.7B01375
Page generated: Wed Dec 16 11:31:21 2020

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