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Zinc in PDB 6adh: Structure of Triclinic Ternary Complex of Horse Liver Alcohol Dehydrogenase at 2.9 Angstroms Resolution

Enzymatic activity of Structure of Triclinic Ternary Complex of Horse Liver Alcohol Dehydrogenase at 2.9 Angstroms Resolution

All present enzymatic activity of Structure of Triclinic Ternary Complex of Horse Liver Alcohol Dehydrogenase at 2.9 Angstroms Resolution:
1.1.1.1;

Protein crystallography data

The structure of Structure of Triclinic Ternary Complex of Horse Liver Alcohol Dehydrogenase at 2.9 Angstroms Resolution, PDB code: 6adh was solved by H.Eklund, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) N/A / 2.90
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 52.000, 44.600, 94.400, 104.40, 101.90, 70.70
R / Rfree (%) n/a / n/a

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Triclinic Ternary Complex of Horse Liver Alcohol Dehydrogenase at 2.9 Angstroms Resolution (pdb code 6adh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of Triclinic Ternary Complex of Horse Liver Alcohol Dehydrogenase at 2.9 Angstroms Resolution, PDB code: 6adh:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 6adh

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Zinc binding site 1 out of 4 in the Structure of Triclinic Ternary Complex of Horse Liver Alcohol Dehydrogenase at 2.9 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Triclinic Ternary Complex of Horse Liver Alcohol Dehydrogenase at 2.9 Angstroms Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn375

b:16.7
occ:1.00
 O A:DMS378 2.1 16.7 1.0
NE2 A:HIS67 2.3 16.7 1.0
SG A:CYS174 2.3 16.7 1.0
SG A:CYS46 2.4 16.7 1.0
CE1 A:HIS67 3.2 16.7 1.0
CD2 A:HIS67 3.3 16.7 1.0
S A:DMS378 3.5 16.7 1.0
CB A:CYS46 3.5 16.7 1.0
CB A:CYS174 3.5 16.7 1.0
C5N A:NAD377 3.7 16.7 1.0
OE2 A:GLU68 4.2 16.7 1.0
C4N A:NAD377 4.3 16.7 1.0
ND1 A:HIS67 4.3 16.7 1.0
C6N A:NAD377 4.3 16.7 1.0
C1 A:DMS378 4.4 16.7 1.0
CG A:HIS67 4.4 16.7 1.0
NH2 A:ARG369 4.6 16.7 1.0
CE1 A:PHE93 4.6 16.7 1.0
CB A:SER48 4.6 16.7 1.0
CB A:GLU68 4.7 16.7 1.0
C2 A:DMS378 4.7 16.7 1.0
CA A:CYS174 4.8 16.7 1.0
N A:GLY175 4.9 16.7 1.0
CA A:CYS46 4.9 16.7 1.0
CZ A:PHE93 5.0 16.7 1.0

Zinc binding site 2 out of 4 in 6adh

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Zinc binding site 2 out of 4 in the Structure of Triclinic Ternary Complex of Horse Liver Alcohol Dehydrogenase at 2.9 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Triclinic Ternary Complex of Horse Liver Alcohol Dehydrogenase at 2.9 Angstroms Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn376

b:16.7
occ:1.00
 SG A:CYS103 2.2 16.7 1.0
SG A:CYS111 2.3 16.7 1.0
SG A:CYS100 2.3 16.7 1.0
SG A:CYS97 2.4 16.7 1.0
CB A:CYS103 3.1 16.7 1.0
CB A:CYS111 3.4 16.7 1.0
CB A:CYS97 3.7 16.7 1.0
CA A:CYS111 3.8 16.7 1.0
N A:CYS97 3.8 16.7 1.0
CB A:CYS100 4.0 16.7 1.0
CA A:CYS103 4.1 16.7 1.0
N A:LEU112 4.2 16.7 1.0
C A:GLN96 4.2 16.7 1.0
N A:CYS103 4.2 16.7 1.0
CA A:CYS97 4.2 16.7 1.0
C A:CYS111 4.4 16.7 1.0
N A:GLY98 4.5 16.7 1.0
CA A:GLN96 4.5 16.7 1.0
O A:CYS100 4.5 16.7 1.0
C A:CYS97 4.7 16.7 1.0
O A:GLN96 4.8 16.7 1.0
N A:LYS113 4.9 16.7 1.0
CA A:CYS100 4.9 16.7 1.0

Zinc binding site 3 out of 4 in 6adh

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Zinc binding site 3 out of 4 in the Structure of Triclinic Ternary Complex of Horse Liver Alcohol Dehydrogenase at 2.9 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of Triclinic Ternary Complex of Horse Liver Alcohol Dehydrogenase at 2.9 Angstroms Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn375

b:16.7
occ:1.00
 O B:DMS378 2.1 16.7 1.0
NE2 B:HIS67 2.2 16.7 1.0
SG B:CYS174 2.3 16.7 1.0
SG B:CYS46 2.4 16.7 1.0
CB B:CYS174 3.0 16.7 1.0
CD2 B:HIS67 3.2 16.7 1.0
CE1 B:HIS67 3.2 16.7 1.0
S B:DMS378 3.5 16.7 1.0
C5N B:NAD377 3.5 16.7 1.0
CB B:CYS46 3.9 16.7 1.0
C4N B:NAD377 3.9 16.7 1.0
C1 B:DMS378 4.2 16.7 1.0
OE2 B:GLU68 4.3 16.7 1.0
C6N B:NAD377 4.3 16.7 1.0
ND1 B:HIS67 4.3 16.7 1.0
CG B:HIS67 4.3 16.7 1.0
CA B:CYS174 4.5 16.7 1.0
CB B:SER48 4.5 16.7 1.0
N B:GLY175 4.6 16.7 1.0
CE1 B:PHE93 4.7 16.7 1.0
OG B:SER48 4.7 16.7 1.0
C2 B:DMS378 4.8 16.7 1.0
CA B:CYS46 4.8 16.7 1.0
CZ B:PHE93 5.0 16.7 1.0

Zinc binding site 4 out of 4 in 6adh

Go back to Zinc Binding Sites List in 6adh
Zinc binding site 4 out of 4 in the Structure of Triclinic Ternary Complex of Horse Liver Alcohol Dehydrogenase at 2.9 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of Triclinic Ternary Complex of Horse Liver Alcohol Dehydrogenase at 2.9 Angstroms Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn376

b:16.7
occ:1.00
 SG B:CYS97 1.8 16.7 1.0
SG B:CYS111 2.4 16.7 1.0
SG B:CYS100 2.4 16.7 1.0
SG B:CYS103 2.5 16.7 1.0
CB B:CYS103 2.7 16.7 1.0
CB B:CYS111 3.4 16.7 1.0
O B:CYS111 3.5 16.7 0.0
CA B:CYS111 3.5 16.7 1.0
N B:CYS97 3.5 16.7 1.0
CB B:CYS97 3.5 16.7 1.0
C B:CYS111 3.6 16.7 1.0
CB B:CYS100 3.7 16.7 1.0
C B:GLN96 3.8 16.7 1.0
CA B:CYS103 3.9 16.7 1.0
N B:GLY98 3.9 16.7 1.0
CA B:CYS97 4.0 16.7 1.0
N B:CYS100 4.1 16.7 1.0
N B:CYS103 4.1 16.7 1.0
O B:CYS100 4.2 16.7 0.0
CA B:GLN96 4.2 16.7 1.0
O B:GLN96 4.3 16.7 0.0
CA B:CYS100 4.3 16.7 1.0
C B:CYS100 4.5 16.7 1.0
C B:CYS97 4.5 16.7 1.0
N B:LEU112 4.6 16.7 1.0
N B:LYS99 4.7 16.7 1.0
N B:CYS111 4.9 16.7 1.0
CA B:GLY98 5.0 16.7 1.0

Reference:

H.Eklund, J.P.Samma, L.Wallen, C.I.Branden, A.Akeson, T.A.Jones. Structure of A Triclinic Ternary Complex of Horse Liver Alcohol Dehydrogenase at 2.9 A Resolution. J.Mol.Biol. V. 146 561 1981.
ISSN: ISSN 0022-2836
PubMed: 7024556
DOI: 10.1016/0022-2836(81)90047-4
Page generated: Mon Oct 28 17:29:20 2024

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