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Atomistry » Zinc » PDB 5olm-5ph9 » 5owt » |
Zinc in PDB 5owt: Crystal Structure of TNKS2 in Complex with (5S)-5-Methyl-5-[4-(4-Oxo- 3,4-Dihydroquinazolin-2-Yl)Phenyl]Imidazolidine-2,4-DioneEnzymatic activity of Crystal Structure of TNKS2 in Complex with (5S)-5-Methyl-5-[4-(4-Oxo- 3,4-Dihydroquinazolin-2-Yl)Phenyl]Imidazolidine-2,4-Dione
All present enzymatic activity of Crystal Structure of TNKS2 in Complex with (5S)-5-Methyl-5-[4-(4-Oxo- 3,4-Dihydroquinazolin-2-Yl)Phenyl]Imidazolidine-2,4-Dione:
2.4.2.30; Protein crystallography data
The structure of Crystal Structure of TNKS2 in Complex with (5S)-5-Methyl-5-[4-(4-Oxo- 3,4-Dihydroquinazolin-2-Yl)Phenyl]Imidazolidine-2,4-Dione, PDB code: 5owt
was solved by
Y.Nkizinkiko,
T.Haikarainen,
L.Lehtio,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of TNKS2 in Complex with (5S)-5-Methyl-5-[4-(4-Oxo- 3,4-Dihydroquinazolin-2-Yl)Phenyl]Imidazolidine-2,4-Dione
(pdb code 5owt). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of TNKS2 in Complex with (5S)-5-Methyl-5-[4-(4-Oxo- 3,4-Dihydroquinazolin-2-Yl)Phenyl]Imidazolidine-2,4-Dione, PDB code: 5owt: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 5owtGo back to Zinc Binding Sites List in 5owt
Zinc binding site 1 out
of 2 in the Crystal Structure of TNKS2 in Complex with (5S)-5-Methyl-5-[4-(4-Oxo- 3,4-Dihydroquinazolin-2-Yl)Phenyl]Imidazolidine-2,4-Dione
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 5owtGo back to Zinc Binding Sites List in 5owt
Zinc binding site 2 out
of 2 in the Crystal Structure of TNKS2 in Complex with (5S)-5-Methyl-5-[4-(4-Oxo- 3,4-Dihydroquinazolin-2-Yl)Phenyl]Imidazolidine-2,4-Dione
Mono view Stereo pair view
Reference:
Y.Nkizinkiko,
J.Desantis,
J.Koivunen,
T.Haikarainen,
S.Murthy,
L.Sancineto,
S.Massari,
F.Ianni,
E.Obaji,
M.I.Loza,
T.Pihlajaniemi,
J.Brea,
O.Tabarrini,
L.Lehtio.
2-Phenylquinazolinones As Dual-Activity Tankyrase-Kinase Inhibitors. Sci Rep V. 8 1680 2018.
Page generated: Wed Dec 16 06:39:37 2020
ISSN: ESSN 2045-2322 PubMed: 29374194 DOI: 10.1038/S41598-018-19872-3 |
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