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Zinc in PDB 5of0: X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii), the E424M Inactive Mutant, in Complex with A Inhibitor Cfbzog
Enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii), the E424M Inactive Mutant, in Complex with A Inhibitor Cfbzog
All present enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii), the E424M Inactive Mutant, in Complex with A Inhibitor Cfbzog:
3.4.17.21;
3.4.17.21;
Protein crystallography data
The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii), the E424M Inactive Mutant, in Complex with A Inhibitor Cfbzog, PDB code: 5of0
was solved by
Z.Novakova,
L.Motlova,
C.Barinka,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 49.25 / 1.48 |
| Space group | I 2 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 101.467, 130.461, 159.574, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 15.7 / 17.2 |
Other elements in 5of0:
The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii), the E424M Inactive Mutant, in Complex with A Inhibitor Cfbzog also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
| Calcium | (Ca) | 1 atom |
| Chlorine | (Cl) | 1 atom |
Zinc Binding Sites:
The binding sites of Zinc atom in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii), the E424M Inactive Mutant, in Complex with A Inhibitor Cfbzog
(pdb code 5of0). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii), the E424M Inactive Mutant, in Complex with A Inhibitor Cfbzog, PDB code: 5of0:
Jump to Zinc binding site number: 1; 2;
In total 2 binding sites of Zinc where determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii), the E424M Inactive Mutant, in Complex with A Inhibitor Cfbzog, PDB code: 5of0:
Jump to Zinc binding site number: 1; 2;
Zinc binding site 1 out of 2 in 5of0
Go back to
Zinc Binding Sites List in 5of0
Zinc binding site 1 out
of 2 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii), the E424M Inactive Mutant, in Complex with A Inhibitor Cfbzog
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii), the E424M Inactive Mutant, in Complex with A Inhibitor Cfbzog within 5.0Å range:
|
Zinc binding site 2 out of 2 in 5of0
Go back to
Zinc Binding Sites List in 5of0
Zinc binding site 2 out
of 2 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii), the E424M Inactive Mutant, in Complex with A Inhibitor Cfbzog
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii), the E424M Inactive Mutant, in Complex with A Inhibitor Cfbzog within 5.0Å range:
|
Reference:
R.Nakajima,
Z.Novakova,
W.Tueckmantel,
L.Motlova,
C.Barinka,
A.P.Kozikowski.
2-Aminoadipic Acid-C(O)-Glutamate Based Prostate-Specific Membrane Antigen Ligands For Potential Use As Theranostics. Acs Med Chem Lett V. 9 1099 2018.
ISSN: ISSN 1948-5875
PubMed: 30429952
DOI: 10.1021/ACSMEDCHEMLETT.8B00318
Page generated: Sun Oct 27 23:27:43 2024
ISSN: ISSN 1948-5875
PubMed: 30429952
DOI: 10.1021/ACSMEDCHEMLETT.8B00318
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