Zinc in PDB 5hyn: Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide
Enzymatic activity of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide
All present enzymatic activity of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide:
2.1.1.43;
Protein crystallography data
The structure of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide, PDB code: 5hyn
was solved by
Y.Zhang,
N.Justin,
J.R.Wilson,
S.J.Gamblin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
95.01 /
2.95
|
Space group
|
P 21 21 21
|
Cell size a, b, c (Å), α, β, γ (°)
|
131.640,
171.510,
274.550,
90.00,
90.00,
90.00
|
R / Rfree (%)
|
21.9 /
27.3
|
Zinc Binding Sites:
Pages:
>>> Page 1 <<<
Page 2, Binding sites: 11 -
20;
Page 3, Binding sites: 21 -
30;
Page 4, Binding sites: 31 -
32;
Binding sites:
The binding sites of Zinc atom in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide
(pdb code 5hyn). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 32 binding sites of Zinc where determined in the
Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide, PDB code: 5hyn:
Jump to Zinc binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Zinc binding site 1 out
of 32 in 5hyn
Go back to
Zinc Binding Sites List in 5hyn
Zinc binding site 1 out
of 32 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1001
b:54.8
occ:1.00
|
ND1
|
A:HIS297
|
2.0
|
64.7
|
1.0
|
SG
|
A:CYS289
|
2.1
|
41.5
|
1.0
|
SG
|
A:CYS294
|
2.1
|
56.1
|
0.9
|
SG
|
A:CYS286
|
2.3
|
49.4
|
1.0
|
CE1
|
A:HIS297
|
2.9
|
54.5
|
1.0
|
CB
|
A:CYS294
|
3.0
|
49.9
|
1.0
|
CG
|
A:HIS297
|
3.1
|
44.1
|
1.0
|
CB
|
A:CYS286
|
3.3
|
54.3
|
1.0
|
CB
|
A:HIS297
|
3.5
|
38.1
|
1.0
|
CB
|
A:CYS289
|
3.8
|
49.8
|
1.0
|
N
|
A:CYS289
|
4.0
|
62.9
|
1.0
|
NE2
|
A:HIS297
|
4.0
|
66.5
|
1.0
|
N
|
A:HIS297
|
4.1
|
54.5
|
1.0
|
CD2
|
A:HIS297
|
4.1
|
42.4
|
1.0
|
CA
|
A:HIS297
|
4.4
|
52.6
|
1.0
|
CA
|
A:CYS289
|
4.4
|
66.2
|
1.0
|
CA
|
A:CYS294
|
4.4
|
55.8
|
1.0
|
CB
|
A:ARG288
|
4.7
|
45.5
|
1.0
|
CA
|
A:CYS286
|
4.8
|
50.9
|
1.0
|
CB
|
A:LEU296
|
4.9
|
42.6
|
1.0
|
O
|
A:HIS297
|
4.9
|
63.1
|
1.0
|
C
|
A:LEU296
|
4.9
|
45.2
|
1.0
|
C
|
A:ARG288
|
4.9
|
55.3
|
1.0
|
N
|
A:LEU296
|
5.0
|
66.9
|
1.0
|
|
Zinc binding site 2 out
of 32 in 5hyn
Go back to
Zinc Binding Sites List in 5hyn
Zinc binding site 2 out
of 32 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1002
b:64.4
occ:1.00
|
SG
|
A:CYS463
|
2.2
|
61.6
|
1.0
|
CB
|
A:CYS320
|
2.2
|
94.4
|
1.0
|
SG
|
A:CYS452
|
2.3
|
60.5
|
0.9
|
SG
|
A:CYS320
|
2.5
|
77.9
|
1.0
|
SG
|
A:CYS324
|
2.9
|
82.7
|
1.0
|
CB
|
A:CYS463
|
3.1
|
49.7
|
1.0
|
CA
|
A:CYS320
|
3.2
|
99.0
|
1.0
|
CB
|
A:CYS452
|
3.3
|
70.2
|
1.0
|
CA
|
A:CYS452
|
3.4
|
60.8
|
1.0
|
CB
|
A:CYS324
|
3.7
|
72.7
|
1.0
|
N
|
A:CYS320
|
3.7
|
0.2
|
1.0
|
N
|
A:CYS452
|
4.0
|
57.4
|
1.0
|
CD1
|
A:TYR325
|
4.1
|
79.5
|
1.0
|
CA
|
A:CYS324
|
4.2
|
81.9
|
1.0
|
N
|
A:TYR325
|
4.4
|
85.8
|
1.0
|
CE1
|
A:TYR325
|
4.5
|
72.1
|
1.0
|
C
|
A:CYS320
|
4.5
|
95.8
|
1.0
|
CA
|
A:CYS463
|
4.5
|
51.9
|
1.0
|
C
|
A:CYS452
|
4.7
|
58.0
|
1.0
|
C
|
A:CYS324
|
4.9
|
93.7
|
1.0
|
C
|
A:PHE451
|
4.9
|
57.3
|
1.0
|
C
|
A:PRO319
|
5.0
|
94.1
|
1.0
|
|
Zinc binding site 3 out
of 32 in 5hyn
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Zinc Binding Sites List in 5hyn
Zinc binding site 3 out
of 32 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1003
b:51.6
occ:1.00
|
SG
|
A:CYS530
|
2.2
|
52.5
|
1.0
|
SG
|
A:CYS553
|
2.3
|
59.8
|
1.0
|
SG
|
A:CYS543
|
2.4
|
56.0
|
1.0
|
SG
|
A:CYS549
|
2.6
|
53.4
|
1.0
|
CB
|
A:CYS530
|
3.1
|
62.7
|
1.0
|
CB
|
A:CYS543
|
3.2
|
54.2
|
1.0
|
CB
|
A:CYS549
|
3.2
|
63.5
|
1.0
|
CB
|
A:CYS553
|
3.3
|
68.3
|
1.0
|
ZN
|
A:ZN1004
|
3.7
|
63.6
|
1.0
|
ZN
|
A:ZN1005
|
3.9
|
56.4
|
1.0
|
SG
|
A:CYS523
|
4.2
|
52.0
|
1.0
|
CG
|
A:ARG556
|
4.5
|
65.7
|
1.0
|
CA
|
A:CYS530
|
4.6
|
70.1
|
1.0
|
CB
|
A:ASN555
|
4.7
|
48.0
|
1.0
|
CA
|
A:CYS543
|
4.7
|
41.0
|
1.0
|
CA
|
A:CYS549
|
4.7
|
59.2
|
1.0
|
CA
|
A:CYS553
|
4.7
|
68.4
|
1.0
|
CB
|
A:CYS547
|
4.9
|
64.1
|
1.0
|
N
|
A:ARG556
|
4.9
|
49.6
|
1.0
|
NE
|
A:ARG556
|
5.0
|
56.0
|
1.0
|
SG
|
A:CYS534
|
5.0
|
52.1
|
1.0
|
N
|
A:CYS530
|
5.0
|
72.5
|
1.0
|
|
Zinc binding site 4 out
of 32 in 5hyn
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Zinc Binding Sites List in 5hyn
Zinc binding site 4 out
of 32 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1004
b:63.6
occ:1.00
|
NE2
|
A:HIS525
|
2.0
|
49.7
|
1.0
|
SG
|
A:CYS534
|
2.1
|
52.1
|
1.0
|
SG
|
A:CYS530
|
2.2
|
52.5
|
1.0
|
SG
|
A:CYS523
|
2.4
|
52.0
|
1.0
|
CE1
|
A:HIS525
|
2.6
|
55.3
|
1.0
|
CB
|
A:CYS530
|
3.2
|
62.7
|
1.0
|
CD2
|
A:HIS525
|
3.3
|
58.3
|
1.0
|
CB
|
A:CYS534
|
3.3
|
64.0
|
1.0
|
CB
|
A:CYS523
|
3.3
|
56.2
|
1.0
|
CA
|
A:CYS530
|
3.7
|
70.1
|
1.0
|
ZN
|
A:ZN1003
|
3.7
|
51.6
|
1.0
|
ND1
|
A:HIS525
|
3.8
|
51.1
|
1.0
|
ZN
|
A:ZN1005
|
3.8
|
56.4
|
1.0
|
SG
|
A:CYS543
|
3.9
|
56.0
|
1.0
|
CG
|
A:HIS525
|
4.2
|
53.7
|
1.0
|
CB
|
A:CYS549
|
4.3
|
63.5
|
1.0
|
CA
|
A:CYS534
|
4.5
|
68.3
|
1.0
|
N
|
A:CYS530
|
4.5
|
72.5
|
1.0
|
CA
|
A:CYS523
|
4.7
|
64.2
|
1.0
|
SG
|
A:CYS536
|
4.8
|
54.0
|
0.9
|
C
|
A:CYS523
|
4.8
|
74.4
|
1.0
|
CB
|
A:CYS536
|
4.9
|
57.0
|
1.0
|
SG
|
A:CYS549
|
5.0
|
53.4
|
1.0
|
C
|
A:CYS530
|
5.0
|
55.2
|
1.0
|
|
Zinc binding site 5 out
of 32 in 5hyn
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Zinc Binding Sites List in 5hyn
Zinc binding site 5 out
of 32 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 5 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1005
b:56.4
occ:1.00
|
SG
|
A:CYS543
|
2.0
|
56.0
|
1.0
|
SG
|
A:CYS523
|
2.2
|
52.0
|
1.0
|
SG
|
A:CYS536
|
2.3
|
54.0
|
0.9
|
SG
|
A:CYS547
|
2.4
|
66.1
|
1.0
|
CB
|
A:CYS543
|
2.8
|
54.2
|
1.0
|
CA
|
A:CYS543
|
3.3
|
41.0
|
1.0
|
CB
|
A:CYS536
|
3.3
|
57.0
|
1.0
|
CB
|
A:CYS547
|
3.4
|
64.1
|
1.0
|
CB
|
A:CYS523
|
3.5
|
56.2
|
1.0
|
ZN
|
A:ZN1004
|
3.8
|
63.6
|
1.0
|
ZN
|
A:ZN1003
|
3.9
|
51.6
|
1.0
|
N
|
A:CYS523
|
3.9
|
67.0
|
1.0
|
N
|
A:CYS543
|
4.2
|
61.2
|
1.0
|
CA
|
A:CYS523
|
4.2
|
64.2
|
1.0
|
SG
|
A:CYS534
|
4.3
|
52.1
|
1.0
|
SG
|
A:CYS530
|
4.5
|
52.5
|
1.0
|
C
|
A:CYS543
|
4.5
|
50.2
|
1.0
|
N
|
A:GLU544
|
4.6
|
45.2
|
1.0
|
CA
|
A:CYS547
|
4.7
|
47.0
|
1.0
|
CA
|
A:CYS536
|
4.7
|
69.1
|
1.0
|
O
|
A:CYS523
|
4.7
|
62.8
|
1.0
|
SG
|
A:CYS549
|
4.8
|
53.4
|
1.0
|
C
|
A:PRO522
|
4.8
|
60.1
|
1.0
|
C
|
A:CYS523
|
4.9
|
74.4
|
1.0
|
CE1
|
A:TYR520
|
4.9
|
63.7
|
1.0
|
O
|
A:PHE542
|
5.0
|
63.4
|
1.0
|
N
|
A:CYS536
|
5.0
|
61.8
|
1.0
|
C
|
A:PHE542
|
5.0
|
64.4
|
1.0
|
|
Zinc binding site 6 out
of 32 in 5hyn
Go back to
Zinc Binding Sites List in 5hyn
Zinc binding site 6 out
of 32 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 6 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1006
b:58.6
occ:1.00
|
SG
|
A:CYS580
|
2.1
|
44.1
|
1.0
|
SG
|
A:CYS566
|
2.3
|
66.5
|
1.0
|
SG
|
A:CYS601
|
2.3
|
53.8
|
1.0
|
SG
|
A:CYS588
|
2.3
|
66.8
|
1.0
|
CB
|
A:CYS588
|
3.1
|
62.0
|
1.0
|
ZN
|
A:ZN1008
|
3.3
|
58.0
|
1.0
|
CB
|
A:CYS580
|
3.4
|
56.5
|
1.0
|
ZN
|
A:ZN1007
|
3.6
|
52.7
|
1.0
|
SG
|
A:CYS560
|
3.6
|
50.0
|
1.0
|
CB
|
A:CYS601
|
3.7
|
66.0
|
1.0
|
CB
|
A:CYS566
|
4.0
|
73.4
|
1.0
|
CB
|
A:CYS585
|
4.4
|
43.9
|
1.0
|
CA
|
A:CYS588
|
4.6
|
63.9
|
1.0
|
CB
|
A:ASN603
|
4.6
|
58.9
|
1.0
|
CB
|
A:ALA590
|
4.6
|
59.5
|
1.0
|
CA
|
A:CYS601
|
4.7
|
66.2
|
1.0
|
CA
|
A:CYS580
|
4.7
|
58.2
|
1.0
|
O
|
A:ALA564
|
4.8
|
90.7
|
1.0
|
N
|
A:ALA590
|
4.9
|
60.9
|
1.0
|
SG
|
A:CYS585
|
4.9
|
41.5
|
1.0
|
SG
|
A:CYS571
|
4.9
|
50.4
|
1.0
|
O
|
A:GLN565
|
5.0
|
66.8
|
1.0
|
C
|
A:CYS588
|
5.0
|
66.3
|
1.0
|
|
Zinc binding site 7 out
of 32 in 5hyn
Go back to
Zinc Binding Sites List in 5hyn
Zinc binding site 7 out
of 32 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 7 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1007
b:52.7
occ:1.00
|
SG
|
A:CYS585
|
2.2
|
41.5
|
1.0
|
SG
|
A:CYS560
|
2.2
|
50.0
|
1.0
|
SG
|
A:CYS573
|
2.3
|
59.2
|
1.0
|
SG
|
A:CYS580
|
2.6
|
44.1
|
1.0
|
CB
|
A:CYS560
|
2.9
|
66.5
|
1.0
|
CB
|
A:CYS585
|
3.1
|
43.9
|
1.0
|
ZN
|
A:ZN1008
|
3.3
|
58.0
|
1.0
|
CB
|
A:CYS573
|
3.4
|
51.6
|
1.0
|
N
|
A:CYS560
|
3.4
|
43.1
|
1.0
|
CB
|
A:CYS580
|
3.6
|
56.5
|
1.0
|
ZN
|
A:ZN1006
|
3.6
|
58.6
|
1.0
|
CA
|
A:CYS560
|
3.7
|
61.2
|
1.0
|
CA
|
A:CYS580
|
3.8
|
58.2
|
1.0
|
SG
|
A:CYS571
|
4.0
|
50.4
|
1.0
|
C
|
A:GLY559
|
4.3
|
40.5
|
1.0
|
CA
|
A:CYS585
|
4.4
|
47.3
|
1.0
|
C
|
A:CYS560
|
4.5
|
62.6
|
1.0
|
SG
|
A:CYS588
|
4.6
|
66.8
|
1.0
|
O
|
A:CYS560
|
4.6
|
69.8
|
1.0
|
N
|
A:ASP581
|
4.7
|
48.1
|
1.0
|
CA
|
A:CYS573
|
4.7
|
47.3
|
1.0
|
N
|
A:CYS580
|
4.8
|
72.0
|
1.0
|
CA
|
A:GLY559
|
4.8
|
57.4
|
1.0
|
SG
|
A:CYS566
|
4.8
|
66.5
|
1.0
|
C
|
A:CYS580
|
4.8
|
49.9
|
1.0
|
N
|
A:CYS573
|
4.8
|
44.3
|
1.0
|
|
Zinc binding site 8 out
of 32 in 5hyn
Go back to
Zinc Binding Sites List in 5hyn
Zinc binding site 8 out
of 32 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 8 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1008
b:58.0
occ:1.00
|
SG
|
A:CYS560
|
2.0
|
50.0
|
1.0
|
SG
|
A:CYS571
|
2.2
|
50.4
|
1.0
|
SG
|
A:CYS562
|
2.4
|
39.2
|
1.0
|
SG
|
A:CYS566
|
2.7
|
66.5
|
1.0
|
CB
|
A:CYS566
|
2.7
|
73.4
|
1.0
|
CB
|
A:CYS560
|
3.0
|
66.5
|
1.0
|
CB
|
A:CYS562
|
3.2
|
60.7
|
1.0
|
CB
|
A:CYS571
|
3.3
|
48.5
|
1.0
|
ZN
|
A:ZN1006
|
3.3
|
58.6
|
1.0
|
ZN
|
A:ZN1007
|
3.3
|
52.7
|
1.0
|
SG
|
A:CYS580
|
3.8
|
44.1
|
1.0
|
CA
|
A:CYS571
|
4.2
|
49.9
|
1.0
|
CA
|
A:CYS566
|
4.2
|
74.8
|
1.0
|
N
|
A:CYS562
|
4.4
|
62.3
|
1.0
|
CA
|
A:CYS562
|
4.4
|
60.2
|
1.0
|
CA
|
A:CYS560
|
4.4
|
61.2
|
1.0
|
SG
|
A:CYS573
|
4.6
|
59.2
|
1.0
|
CB
|
A:CYS588
|
4.6
|
62.0
|
1.0
|
CB
|
A:CYS573
|
4.7
|
51.6
|
1.0
|
SG
|
A:CYS588
|
4.7
|
66.8
|
1.0
|
O
|
A:CYS566
|
4.8
|
47.9
|
1.0
|
C
|
A:CYS560
|
4.9
|
62.6
|
1.0
|
CD
|
A:PRO572
|
4.9
|
43.3
|
1.0
|
C
|
A:CYS571
|
4.9
|
43.5
|
1.0
|
|
Zinc binding site 9 out
of 32 in 5hyn
Go back to
Zinc Binding Sites List in 5hyn
Zinc binding site 9 out
of 32 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 9 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:Zn1001
b:63.9
occ:1.00
|
CD2
|
F:HIS297
|
1.9
|
81.4
|
1.0
|
SG
|
F:CYS289
|
2.1
|
59.3
|
1.0
|
SG
|
F:CYS286
|
2.2
|
75.2
|
0.9
|
SG
|
F:CYS294
|
2.3
|
68.2
|
1.0
|
NE2
|
F:HIS297
|
2.7
|
76.3
|
1.0
|
CG
|
F:HIS297
|
2.8
|
58.6
|
1.0
|
CB
|
F:CYS294
|
3.2
|
70.6
|
1.0
|
CB
|
F:CYS286
|
3.3
|
70.3
|
1.0
|
CB
|
F:HIS297
|
3.5
|
53.1
|
1.0
|
CB
|
F:CYS289
|
3.5
|
65.0
|
1.0
|
N
|
F:CYS289
|
3.8
|
64.2
|
1.0
|
CE1
|
F:HIS297
|
3.8
|
67.7
|
1.0
|
ND1
|
F:HIS297
|
3.8
|
42.8
|
1.0
|
CA
|
F:CYS289
|
4.2
|
72.6
|
1.0
|
N
|
F:HIS297
|
4.2
|
59.4
|
1.0
|
CB
|
F:ARG288
|
4.4
|
51.2
|
1.0
|
CA
|
F:HIS297
|
4.5
|
64.9
|
1.0
|
C
|
F:ARG288
|
4.7
|
49.8
|
1.0
|
CA
|
F:CYS294
|
4.7
|
66.4
|
1.0
|
CA
|
F:CYS286
|
4.7
|
62.8
|
1.0
|
CB
|
F:LEU296
|
4.8
|
47.1
|
1.0
|
CA
|
F:ARG288
|
4.9
|
50.4
|
1.0
|
N
|
F:ARG288
|
4.9
|
69.8
|
1.0
|
C
|
F:CYS289
|
5.0
|
74.7
|
1.0
|
C
|
F:LEU296
|
5.0
|
55.3
|
1.0
|
|
Zinc binding site 10 out
of 32 in 5hyn
Go back to
Zinc Binding Sites List in 5hyn
Zinc binding site 10 out
of 32 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 10 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Oncogenic Histone H3K27M Peptide within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:Zn1002
b:0.9
occ:1.00
|
SG
|
F:CYS463
|
2.2
|
85.5
|
1.0
|
CB
|
F:CYS320
|
2.4
|
0.5
|
1.0
|
SG
|
F:CYS452
|
2.6
|
92.4
|
1.0
|
SG
|
F:CYS324
|
2.7
|
97.5
|
1.0
|
SG
|
F:CYS320
|
2.7
|
88.5
|
1.0
|
CB
|
F:CYS463
|
2.9
|
76.8
|
1.0
|
CB
|
F:CYS324
|
3.4
|
92.5
|
1.0
|
CA
|
F:CYS320
|
3.5
|
0.7
|
1.0
|
CB
|
F:CYS452
|
3.6
|
96.8
|
1.0
|
CA
|
F:CYS452
|
3.6
|
90.4
|
1.0
|
N
|
F:CYS320
|
3.7
|
0.6
|
1.0
|
CA
|
F:CYS324
|
3.8
|
0.4
|
1.0
|
N
|
F:CYS452
|
4.1
|
85.0
|
1.0
|
CD1
|
F:TYR325
|
4.1
|
0.8
|
1.0
|
N
|
F:TYR325
|
4.1
|
0.5
|
1.0
|
CA
|
F:CYS463
|
4.3
|
90.7
|
1.0
|
C
|
F:CYS324
|
4.5
|
0.6
|
1.0
|
CE1
|
F:TYR325
|
4.5
|
100.0
|
1.0
|
C
|
F:CYS320
|
4.8
|
0.3
|
1.0
|
C
|
F:PRO319
|
4.9
|
0.6
|
1.0
|
C
|
F:PHE451
|
4.9
|
86.1
|
1.0
|
N
|
F:CYS324
|
5.0
|
0.8
|
1.0
|
C
|
F:CYS452
|
5.0
|
87.1
|
1.0
|
|
Reference:
N.Justin,
Y.Zhang,
C.Tarricone,
S.R.Martin,
S.Chen,
E.Underwood,
V.De Marco,
L.F.Haire,
P.A.Walker,
D.Reinberg,
J.R.Wilson,
S.J.Gamblin.
Structural Basis of Oncogenic Histone H3K27M Inhibition of Human Polycomb Repressive Complex 2. Nat Commun V. 7 11316 2016.
ISSN: ESSN 2041-1723
PubMed: 27121947
DOI: 10.1038/NCOMMS11316
Page generated: Sun Oct 27 17:42:59 2024
|