Zinc in PDB 5hvw: Monomeric IGG4 Fc

The structure of Monomeric IGG4 Fc, PDB code: 5hvw was solved by V.Y.Oganesyan, L.Shan, W.F.Dall'acqua, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.00 / 1.95
Space group	H 3 2
Cell size a, b, c (Å), α, β, γ (°)	121.379, 121.379, 99.729, 90.00, 90.00, 120.00
R / Rfree (%)	20.9 / 25.8

The binding sites of Zinc atom in the Monomeric IGG4 Fc (pdb code 5hvw). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Monomeric IGG4 Fc, PDB code: 5hvw:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Monomeric IGG4 Fc


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Monomeric IGG4 Fc within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn510 b:43.5 occ:0.31 O A:HOH653 2.0 41.5 1.0 NE2 A:HIS285 2.4 50.5 1.0 CD2 A:HIS285 3.2 50.8 1.0 CE1 A:HIS285 3.4 51.3 1.0 O A:HOH615 4.2 46.7 1.0 CG A:HIS285 4.4 50.2 1.0 ND1 A:HIS285 4.4 52.2 1.0 O A:GLU283 4.5 47.1 1.0 O A:HOH676 4.9 75.9 0.3

Zinc binding site 2 out of 2 in the Monomeric IGG4 Fc


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Monomeric IGG4 Fc within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn511 b:44.0 occ:1.00 NE2 A:HIS435 1.9 41.1 1.0 NE2 A:HIS433 2.1 49.1 1.0 O A:HOH671 2.2 34.5 1.0 CE1 A:HIS435 2.9 41.2 1.0 CD2 A:HIS435 2.9 42.1 1.0 CD2 A:HIS433 3.1 52.4 1.0 CE1 A:HIS433 3.1 50.1 1.0 ND1 A:HIS435 4.0 40.0 1.0 CG A:HIS435 4.1 40.8 1.0 ND1 A:HIS433 4.2 48.0 1.0 CG A:HIS433 4.3 49.2 1.0

L.Shan, M.Colazet, K.L.Rosenthal, X.Q.Yu, J.S.Bee, A.Ferguson, M.M.Damschroder, H.Wu, W.F.Dall'acqua, P.Tsui, V.Oganesyan. Generation and Characterization of An IGG4 Monomeric Fc Platform. Plos One V. 11 60345 2016.
ISSN: ESSN 1932-6203
PubMed: 27479095
DOI: 10.1371/JOURNAL.PONE.0160345