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Zinc in PDB 5hvh: Crystal Structure of Thrombin-Activatable Fibrinolysis Inhibitor in Complex with Two Inhibitory Nanobodies

Enzymatic activity of Crystal Structure of Thrombin-Activatable Fibrinolysis Inhibitor in Complex with Two Inhibitory Nanobodies

All present enzymatic activity of Crystal Structure of Thrombin-Activatable Fibrinolysis Inhibitor in Complex with Two Inhibitory Nanobodies:
3.4.17.20;

Protein crystallography data

The structure of Crystal Structure of Thrombin-Activatable Fibrinolysis Inhibitor in Complex with Two Inhibitory Nanobodies, PDB code: 5hvh was solved by X.Zhou, S.D.Weeks, S.V.Strelkov, P.J.Declerck, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.25 / 3.00
Space group P 62 2 2
Cell size a, b, c (Å), α, β, γ (°) 196.986, 196.986, 147.512, 90.00, 90.00, 120.00
R / Rfree (%) 19 / 20.2

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Thrombin-Activatable Fibrinolysis Inhibitor in Complex with Two Inhibitory Nanobodies (pdb code 5hvh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Thrombin-Activatable Fibrinolysis Inhibitor in Complex with Two Inhibitory Nanobodies, PDB code: 5hvh:

Zinc binding site 1 out of 1 in 5hvh

Go back to Zinc Binding Sites List in 5hvh
Zinc binding site 1 out of 1 in the Crystal Structure of Thrombin-Activatable Fibrinolysis Inhibitor in Complex with Two Inhibitory Nanobodies


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Thrombin-Activatable Fibrinolysis Inhibitor in Complex with Two Inhibitory Nanobodies within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn508

b:59.5
occ:1.00
 ND1 A:HIS159 2.1 42.2 1.0
ND1 A:HIS288 2.2 48.0 1.0
OE1 A:GLU162 2.3 48.4 1.0
OE2 A:GLU162 2.5 67.1 1.0
CD A:GLU162 2.7 75.5 1.0
CE1 A:HIS159 3.0 40.6 1.0
CG A:HIS288 3.1 46.1 1.0
CE1 A:HIS288 3.1 47.5 1.0
CG A:HIS159 3.3 41.1 1.0
CB A:HIS288 3.4 42.6 1.0
CB A:HIS159 3.7 39.0 1.0
OE2 A:GLU363 4.1 99.1 1.0
NE2 A:HIS159 4.2 40.3 1.0
CD2 A:HIS288 4.2 47.9 1.0
O A:SER289 4.2 50.0 1.0
NE2 A:HIS288 4.2 47.8 1.0
CG A:GLU162 4.2 47.3 1.0
OE1 A:GLU363 4.3 89.6 1.0
CA A:HIS288 4.3 41.7 1.0
CD2 A:HIS159 4.3 41.5 1.0
NH1 A:ARG217 4.4 37.5 1.0
N A:SER289 4.5 43.5 1.0
CD A:GLU363 4.6 92.4 1.0
C A:HIS288 5.0 47.6 1.0

Reference:

X.Zhou, S.D.Weeks, P.Ameloot, N.Callewaert, S.V.Strelkov, P.J.Declerck. Elucidation of the Molecular Mechanisms of Two Nanobodies That Inhibit Thrombin-Activatable Fibrinolysis Inhibitor Activation and Activated Thrombin-Activatable Fibrinolysis Inhibitor Activity. J.Thromb.Haemost. V. 14 1629 2016.
ISSN: ESSN 1538-7836
PubMed: 27279497
DOI: 10.1111/JTH.13381
Page generated: Sun Oct 27 17:41:16 2024

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