Zinc in PDB 5hpd: Solution Structure of TAZ2-P53TAD

All present enzymatic activity of Solution Structure of TAZ2-P53TAD:
2.3.1.48;

The binding sites of Zinc atom in the Solution Structure of TAZ2-P53TAD (pdb code 5hpd). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Solution Structure of TAZ2-P53TAD, PDB code: 5hpd:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Solution Structure of TAZ2-P53TAD


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Solution Structure of TAZ2-P53TAD within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:0.0 occ:1.00 NE2 A:HIS1782 2.1 0.0 1.0 SG A:CYS1796 2.3 0.0 1.0 SG A:CYS1791 2.3 0.0 1.0 SG A:CYS1786 2.3 0.0 1.0 CD2 A:HIS1782 2.9 0.0 1.0 HD2 A:HIS1782 2.9 0.0 1.0 CB A:CYS1791 3.0 0.0 1.0 HB3 A:CYS1791 3.0 0.0 1.0 HB2 A:CYS1786 3.0 0.0 1.0 HB2 A:CYS1791 3.0 0.0 1.0 CB A:CYS1786 3.1 0.0 1.0 HB2 A:CYS1796 3.2 0.0 1.0 CE1 A:HIS1782 3.3 0.0 1.0 CB A:CYS1796 3.3 0.0 1.0 HB3 A:CYS1786 3.4 0.0 1.0 HB3 A:CYS1796 3.6 0.0 1.0 HE1 A:HIS1782 3.7 0.0 1.0 HE3 A:LYS1800 3.8 0.0 1.0 HE2 A:LYS1800 3.9 0.0 1.0 HD13 A:LEU1793 3.9 0.0 1.0 HB2 A:LEU1793 4.1 0.0 1.0 CG A:HIS1782 4.1 0.0 1.0 ND1 A:HIS1782 4.3 0.0 1.0 HA A:ALA1783 4.3 0.0 1.0 CE A:LYS1800 4.3 0.0 1.0 CA A:CYS1791 4.5 0.0 1.0 HB3 A:ASN1788 4.6 0.0 1.0 CA A:CYS1786 4.6 0.0 1.0 HD2 A:LYS1800 4.6 0.0 1.0 CA A:CYS1796 4.6 0.0 1.0 HA A:CYS1796 4.7 0.0 1.0 HA A:CYS1786 4.8 0.0 1.0 H A:LEU1793 4.8 0.0 1.0 HA A:CYS1791 4.8 0.0 1.0 H A:ASN1788 4.9 0.0 1.0 O A:ASN1788 4.9 0.0 1.0 CD1 A:LEU1793 4.9 0.0 1.0 O A:HIS1782 4.9 0.0 1.0

Zinc binding site 2 out of 3 in the Solution Structure of TAZ2-P53TAD


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Solution Structure of TAZ2-P53TAD within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn202 b:0.0 occ:1.00 NE2 A:HIS1805 2.1 0.0 1.0 SG A:CYS1820 2.3 0.0 1.0 SG A:CYS1817 2.3 0.0 1.0 SG A:CYS1809 2.3 0.0 1.0 HB2 A:CYS1809 2.9 0.0 1.0 HB3 A:CYS1817 3.0 0.0 1.0 CB A:CYS1809 3.0 0.0 1.0 CD2 A:HIS1805 3.1 0.0 1.0 CB A:CYS1817 3.1 0.0 1.0 CE1 A:HIS1805 3.1 0.0 1.0 HB3 A:CYS1809 3.2 0.0 1.0 HD2 A:HIS1805 3.3 0.0 1.0 HB2 A:CYS1817 3.3 0.0 1.0 H A:CYS1820 3.3 0.0 1.0 HE1 A:HIS1805 3.3 0.0 1.0 HB A:VAL1819 3.5 0.0 1.0 HA A:LYS1812 3.8 0.0 1.0 CB A:CYS1820 4.0 0.0 1.0 H A:LYS1812 4.0 0.0 1.0 HB3 A:ARG1811 4.1 0.0 1.0 HB3 A:LYS1812 4.1 0.0 1.0 HB2 A:CYS1820 4.2 0.0 1.0 HA A:THR1806 4.2 0.0 1.0 ND1 A:HIS1805 4.2 0.0 1.0 CG A:HIS1805 4.2 0.0 1.0 N A:CYS1820 4.2 0.0 1.0 N A:LYS1812 4.4 0.0 1.0 H A:VAL1819 4.4 0.0 1.0 H A:ARG1811 4.4 0.0 1.0 CA A:CYS1809 4.5 0.0 1.0 CA A:CYS1817 4.5 0.0 1.0 CB A:VAL1819 4.6 0.0 1.0 CA A:LYS1812 4.6 0.0 1.0 HA A:CYS1809 4.7 0.0 1.0 HB3 A:CYS1820 4.7 0.0 1.0 CA A:CYS1820 4.8 0.0 1.0 CB A:LYS1812 4.9 0.0 1.0 HG11 A:VAL1819 5.0 0.0 1.0 HA A:CYS1817 5.0 0.0 1.0

Zinc binding site 3 out of 3 in the Solution Structure of TAZ2-P53TAD


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Solution Structure of TAZ2-P53TAD within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn203 b:0.0 occ:1.00 NE2 A:HIS1830 2.1 0.0 1.0 SG A:CYS1839 2.3 0.0 1.0 SG A:CYS1844 2.3 0.0 1.0 SG A:CYS1834 2.3 0.0 1.0 HB2 A:CYS1834 3.0 0.0 1.0 CD2 A:HIS1830 3.0 0.0 1.0 CB A:CYS1834 3.0 0.0 1.0 HD2 A:HIS1830 3.1 0.0 1.0 CE1 A:HIS1830 3.2 0.0 1.0 HB3 A:CYS1834 3.2 0.0 1.0 CB A:CYS1839 3.2 0.0 1.0 HB2 A:CYS1839 3.2 0.0 1.0 HB3 A:CYS1839 3.4 0.0 1.0 HE1 A:HIS1830 3.5 0.0 1.0 CB A:CYS1844 3.5 0.0 1.0 HB2 A:CYS1844 3.6 0.0 1.0 HB A:VAL1841 3.6 0.0 1.0 HB3 A:CYS1844 3.8 0.0 1.0 CG A:HIS1830 4.2 0.0 1.0 HA A:ALA1831 4.2 0.0 1.0 ND1 A:HIS1830 4.2 0.0 1.0 HG23 A:VAL1841 4.3 0.0 1.0 HG21 A:VAL1841 4.3 0.0 1.0 HB3 A:GLU1836 4.3 0.0 1.0 CA A:CYS1834 4.5 0.0 1.0 H A:VAL1841 4.5 0.0 1.0 CB A:VAL1841 4.6 0.0 1.0 CG2 A:VAL1841 4.6 0.0 1.0 HE2 A:LYS1848 4.7 0.0 1.0 H A:GLU1836 4.7 0.0 1.0 CA A:CYS1839 4.7 0.0 1.0 HA A:CYS1834 4.7 0.0 1.0 HD2 A:PRO1840 4.8 0.0 1.0 CA A:CYS1844 4.9 0.0 1.0 HE3 A:LYS1848 4.9 0.0 1.0 HA A:CYS1839 4.9 0.0 1.0

A.S.Krois, J.C.Ferreon, M.A.Martinez-Yamout, H.J.Dyson, P.E.Wright. Recognition of the Disordered P53 Transactivation Domain By the Transcriptional Adapter Zinc Finger Domains of Creb-Binding Protein. Proc.Natl.Acad.Sci.Usa V. 113 E1853 2016.
ISSN: ESSN 1091-6490
PubMed: 26976603
DOI: 10.1073/PNAS.1602487113