Zinc in PDB 5egr: Trna Guanine Transglycosylase (Tgt) in Complex with An Immucillin Derivative

All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Complex with An Immucillin Derivative:
2.4.2.29;

The structure of Trna Guanine Transglycosylase (Tgt) in Complex with An Immucillin Derivative, PDB code: 5egr was solved by F.R.Ehrmann, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.85 / 1.55
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	90.458, 64.485, 70.978, 90.00, 93.25, 90.00
R / Rfree (%)	17.2 / 19.1

The binding sites of Zinc atom in the Trna Guanine Transglycosylase (Tgt) in Complex with An Immucillin Derivative (pdb code 5egr). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna Guanine Transglycosylase (Tgt) in Complex with An Immucillin Derivative, PDB code: 5egr:

Zinc binding site 1 out of 1 in the Trna Guanine Transglycosylase (Tgt) in Complex with An Immucillin Derivative


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna Guanine Transglycosylase (Tgt) in Complex with An Immucillin Derivative within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn405 b:22.0 occ:1.00 ND1 A:HIS349 2.1 21.0 1.0 SG A:CYS323 2.2 21.8 1.0 SG A:CYS318 2.3 24.2 1.0 SG A:CYS320 2.4 20.9 1.0 CE1 A:HIS349 2.9 20.6 1.0 CG A:HIS349 3.2 19.2 1.0 CB A:CYS318 3.3 25.3 1.0 CB A:CYS323 3.3 21.0 1.0 CB A:CYS320 3.4 20.9 1.0 CB A:HIS349 3.7 20.1 1.0 N A:CYS323 3.9 20.6 1.0 NE2 A:HIS349 4.1 21.7 1.0 CA A:HIS349 4.1 17.2 1.0 N A:CYS320 4.1 23.2 1.0 CA A:CYS323 4.2 21.7 1.0 CA A:CYS320 4.2 20.9 1.0 CD2 A:HIS349 4.3 20.0 1.0 O A:HIS349 4.5 20.1 1.0 CA A:CYS318 4.6 25.2 1.0 O A:CYS320 4.6 22.3 1.0 C A:CYS320 4.7 22.7 1.0 C A:CYS318 4.7 24.6 1.0 CB A:VAL322 4.7 19.4 1.0 C A:HIS349 4.8 19.4 1.0 O A:CYS318 4.8 26.6 1.0 C A:VAL322 4.9 21.6 1.0

F.R.Ehrmann, C.Hohn, A.Haertsch, N.Trapp, A.Heine, G.Klebe, F.Diederich. Synthesis of An Immucillin Derivative As A Class of Trna-Guanine Transglycosylase Inhibitors: Exploration of A Transition State Analogous Binding Mode To Be Published.