Zinc in PDB 5dkc: Crystal Structure of the Bromodomain of Human Brm (SMARCA2) in Complex with Pfi-3 Chemical Probe

The structure of Crystal Structure of the Bromodomain of Human Brm (SMARCA2) in Complex with Pfi-3 Chemical Probe, PDB code: 5dkc was solved by C.Tallant, D.R.Owen, B.S.Gerstenberger, O.Fedorov, P.Savitsky, G.Nunez-Alonso, M.Fonseca, T.Krojer, P.Filippakopoulos, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, S.Muller, S.Knapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.19 / 1.60
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	74.424, 74.424, 89.856, 90.00, 90.00, 120.00
R / Rfree (%)	19.4 / 21.1

The binding sites of Zinc atom in the Crystal Structure of the Bromodomain of Human Brm (SMARCA2) in Complex with Pfi-3 Chemical Probe (pdb code 5dkc). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Bromodomain of Human Brm (SMARCA2) in Complex with Pfi-3 Chemical Probe, PDB code: 5dkc:

Zinc binding site 1 out of 1 in the Crystal Structure of the Bromodomain of Human Brm (SMARCA2) in Complex with Pfi-3 Chemical Probe


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Bromodomain of Human Brm (SMARCA2) in Complex with Pfi-3 Chemical Probe within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1501 b:31.4 occ:1.00 NE2 A:HIS1441 2.0 33.2 1.0 O A:HOH1684 2.2 26.9 1.0 O A:HOH1617 2.7 33.5 1.0 CE1 A:HIS1441 2.9 30.5 1.0 CD2 A:HIS1441 3.1 26.9 1.0 O A:ARG1439 4.0 25.0 1.0 ND1 A:HIS1441 4.1 29.1 1.0 CG A:HIS1441 4.2 28.4 1.0

C.Tallant, D.R.Owen, B.S.Gerstenberger, O.Fedorov, P.Savitsky, G.Nunez-Alonso, M.Fonseca, T.Krojer, P.Filippakopoulos, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, S.Muller, S.Knapp. Crystal Structure of the Bromodomain of Human Brm (SMARCA2) in Complex with Pfi-3 Chemical Probe To Be Published.