Zinc in PDB 5dcz: Tankyrase 2 Complexed with A Selective Inhibitor

All present enzymatic activity of Tankyrase 2 Complexed with A Selective Inhibitor:
2.4.2.30;

The structure of Tankyrase 2 Complexed with A Selective Inhibitor, PDB code: 5dcz was solved by L.M.Shewchuk, M.Muelbaier, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	57.58 / 2.23
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	66.599, 66.599, 114.610, 90.00, 90.00, 90.00
R / Rfree (%)	18 / 20.2

The binding sites of Zinc atom in the Tankyrase 2 Complexed with A Selective Inhibitor (pdb code 5dcz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Tankyrase 2 Complexed with A Selective Inhibitor, PDB code: 5dcz:

Zinc binding site 1 out of 1 in the Tankyrase 2 Complexed with A Selective Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Tankyrase 2 Complexed with A Selective Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1201 b:36.9 occ:1.00 ND1 A:HIS1084 2.2 44.7 1.0 SG A:CYS1092 2.3 37.4 1.0 SG A:CYS1081 2.3 36.6 1.0 SG A:CYS1089 2.4 34.0 1.0 CE1 A:HIS1084 3.0 44.6 1.0 CB A:CYS1081 3.2 39.1 1.0 CB A:CYS1092 3.3 35.8 1.0 CG A:HIS1084 3.3 44.6 1.0 CB A:CYS1089 3.3 33.4 1.0 CB A:HIS1084 3.7 43.2 1.0 N A:HIS1084 3.9 43.3 1.0 N A:CYS1092 3.9 34.8 1.0 NE2 A:HIS1084 4.2 45.0 1.0 CA A:CYS1092 4.2 34.9 1.0 O A:HOH1396 4.3 46.3 1.0 CD2 A:HIS1084 4.3 44.9 1.0 O A:HOH1391 4.3 44.2 1.0 CA A:HIS1084 4.4 43.6 1.0 CB A:VAL1083 4.5 44.9 1.0 CA A:CYS1081 4.7 40.2 1.0 CB A:ILE1091 4.7 37.4 1.0 CA A:CYS1089 4.7 33.3 1.0 C A:VAL1083 4.8 44.3 1.0 CG1 A:VAL1083 4.9 45.3 1.0 N A:VAL1083 4.9 44.2 1.0 O A:HOH1305 5.0 39.2 1.0 CA A:VAL1083 5.0 44.4 1.0

M.Muelbaier, L.M.Shewchuk. Discovery of A New Tool Compound with Superior Selectivity to Interrogate the Biology of Tankyrase J.Med.Chem 2015.
ISSN: ISSN 0022-2623