Zinc in PDB 5cvm: USP46~Ubiquitin Bea Covalent Complex

All present enzymatic activity of USP46~Ubiquitin Bea Covalent Complex:
3.4.19.12;

The structure of USP46~Ubiquitin Bea Covalent Complex, PDB code: 5cvm was solved by S.F.Harris, J.Yin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	27.82 / 1.90
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	90.613, 105.120, 134.656, 90.00, 90.00, 90.00
R / Rfree (%)	17.6 / 19.7

The binding sites of Zinc atom in the USP46~Ubiquitin Bea Covalent Complex (pdb code 5cvm). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the USP46~Ubiquitin Bea Covalent Complex, PDB code: 5cvm:

Zinc binding site 1 out of 1 in the USP46~Ubiquitin Bea Covalent Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of USP46~Ubiquitin Bea Covalent Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1000 b:27.9 occ:1.00 SG A:CYS185 2.3 32.6 1.0 SG A:CYS182 2.3 26.6 1.0 SG A:CYS229 2.4 27.3 1.0 SG A:CYS232 2.4 30.3 1.0 CB A:CYS182 3.1 24.0 1.0 CB A:CYS229 3.2 24.2 1.0 CB A:CYS185 3.3 29.7 1.0 CB A:CYS232 3.3 26.8 1.0 N A:CYS185 3.7 30.1 1.0 N A:CYS232 3.8 28.6 1.0 CA A:CYS185 4.1 30.1 1.0 CA A:CYS232 4.2 27.1 1.0 CG A:GLN236 4.4 28.5 1.0 CB A:THR231 4.4 35.3 1.0 CB A:ASN184 4.5 27.5 1.0 CA A:CYS182 4.5 24.5 1.0 CA A:CYS229 4.7 24.9 1.0 C A:ASN184 4.7 33.8 1.0 C A:THR231 4.8 31.9 1.0 CG2 A:THR231 4.8 33.8 1.0 C A:CYS185 4.9 34.3 1.0 O A:HOH1337 4.9 45.1 1.0 CA A:ASN184 4.9 27.7 1.0 N A:ASN184 5.0 27.6 1.0 CB A:GLN236 5.0 23.9 1.0 CA A:THR231 5.0 27.4 1.0 C A:CYS182 5.0 26.9 1.0

J.Yin, A.J.Schoeffler, K.Wickliffe, K.Newton, M.A.Starovasnik, E.C.Dueber, S.F.Harris. Structural Insights Into Wd-Repeat 48 Activation of Ubiquitin-Specific Protease 46. Structure V. 23 2043 2015.
ISSN: ISSN 0969-2126
PubMed: 26388029
DOI: 10.1016/J.STR.2015.08.010