Zinc in PDB 5cc0: ANCSR2 - Tslp Ngre Complex

Protein crystallography data

The structure of ANCSR2 - Tslp Ngre Complex, PDB code: 5cc0 was solved by W.H.Hudson, E.A.Ortlund, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 38.47 / 2.41
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 50.334, 72.507, 104.942, 90.00, 90.00, 90.00
R / Rfree (%) 21.4 / 23.7

Zinc Binding Sites:

The binding sites of Zinc atom in the ANCSR2 - Tslp Ngre Complex (pdb code 5cc0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the ANCSR2 - Tslp Ngre Complex, PDB code: 5cc0:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 5cc0

Go back to Zinc Binding Sites List in 5cc0
Zinc binding site 1 out of 4 in the ANCSR2 - Tslp Ngre Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of ANCSR2 - Tslp Ngre Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:75.1
occ:1.00
SG A:CYS424 2.2 81.6 1.0
SG A:CYS421 2.3 69.9 1.0
SG A:CYS438 2.4 75.6 1.0
SG A:CYS441 2.4 77.5 1.0
CB A:CYS441 3.3 65.4 1.0
CB A:CYS438 3.4 86.7 1.0
CB A:CYS424 3.4 80.6 1.0
CB A:CYS421 3.6 87.8 1.0
N A:CYS424 3.6 80.0 1.0
N A:CYS438 3.8 86.6 1.0
CA A:CYS424 4.0 78.5 1.0
CA A:CYS438 4.2 83.1 1.0
N A:CYS441 4.2 63.6 1.0
OG A:SER440 4.3 77.8 1.0
CA A:CYS441 4.4 68.9 1.0
CB A:ILE423 4.6 78.2 1.0
C A:CYS424 4.6 82.0 1.0
N A:GLY425 4.6 85.2 1.0
C A:ILE423 4.7 80.4 1.0
C A:CYS438 4.8 81.4 1.0
NH2 A:ARG477 4.8 69.1 1.0
CB A:ASP426 4.9 89.4 1.0
N A:ASP426 4.9 86.8 1.0
C A:THR437 5.0 87.6 1.0
CD A:ARG470 5.0 75.9 1.0
CA A:CYS421 5.0 83.8 1.0

Zinc binding site 2 out of 4 in 5cc0

Go back to Zinc Binding Sites List in 5cc0
Zinc binding site 2 out of 4 in the ANCSR2 - Tslp Ngre Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of ANCSR2 - Tslp Ngre Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn502

b:64.0
occ:1.00
SG A:CYS473 2.2 66.1 1.0
SG A:CYS476 2.3 65.5 1.0
SG A:CYS457 2.3 68.9 1.0
SG A:CYS463 2.4 58.7 1.0
CB A:CYS463 3.2 64.5 1.0
CB A:CYS457 3.3 64.1 1.0
CB A:CYS473 3.3 58.3 1.0
CB A:CYS476 3.5 68.7 1.0
CA A:CYS457 4.0 59.4 1.0
O A:HOH601 4.0 63.1 1.0
N A:CYS463 4.2 75.8 1.0
CA A:ASN461 4.3 79.4 1.0
N A:CYS476 4.3 56.5 1.0
CA A:CYS463 4.4 75.7 1.0
CA A:CYS476 4.5 56.7 1.0
N A:ASN461 4.5 82.6 1.0
N A:GLY459 4.7 63.3 1.0
N A:ALA458 4.7 64.6 1.0
CA A:CYS473 4.7 54.4 1.0
C A:CYS457 4.8 60.5 1.0
C A:ASN461 4.8 73.0 1.0
CA A:GLY459 5.0 70.4 1.0

Zinc binding site 3 out of 4 in 5cc0

Go back to Zinc Binding Sites List in 5cc0
Zinc binding site 3 out of 4 in the ANCSR2 - Tslp Ngre Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of ANCSR2 - Tslp Ngre Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn501

b:66.9
occ:1.00
SG B:CYS438 2.3 64.4 1.0
SG B:CYS424 2.3 69.3 1.0
SG B:CYS441 2.3 69.1 1.0
SG B:CYS421 2.3 67.2 1.0
CB B:CYS441 3.2 60.8 1.0
CB B:CYS424 3.3 65.6 1.0
CB B:CYS421 3.4 73.8 1.0
CB B:CYS438 3.5 64.4 1.0
N B:CYS424 3.6 69.3 1.0
N B:CYS438 3.7 70.8 1.0
CA B:CYS424 4.0 74.5 1.0
CA B:CYS438 4.2 68.8 1.0
N B:CYS441 4.3 58.8 1.0
CA B:CYS441 4.3 65.9 1.0
CB B:ILE423 4.4 71.3 1.0
OG B:SER440 4.6 64.5 1.0
CB B:ASP426 4.6 77.0 1.0
C B:CYS424 4.7 76.6 1.0
C B:ILE423 4.7 74.3 1.0
NE B:ARG470 4.7 65.2 1.0
CA B:CYS421 4.8 74.6 1.0
C B:THR437 4.8 73.7 1.0
N B:ASP426 4.9 74.9 1.0
NH2 B:ARG477 4.9 61.0 1.0
C B:CYS438 4.9 67.8 1.0
N B:GLY425 4.9 75.2 1.0
CA B:ILE423 5.0 67.2 1.0

Zinc binding site 4 out of 4 in 5cc0

Go back to Zinc Binding Sites List in 5cc0
Zinc binding site 4 out of 4 in the ANCSR2 - Tslp Ngre Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of ANCSR2 - Tslp Ngre Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn502

b:58.0
occ:1.00
SG B:CYS476 2.2 58.9 1.0
SG B:CYS473 2.3 58.6 1.0
SG B:CYS457 2.3 63.4 1.0
SG B:CYS463 2.4 63.6 1.0
CB B:CYS457 3.1 58.6 1.0
CB B:CYS463 3.3 60.9 1.0
CB B:CYS473 3.5 58.5 1.0
CB B:CYS476 3.5 56.6 1.0
CA B:CYS457 3.9 60.5 1.0
N B:CYS463 4.1 70.5 1.0
N B:CYS476 4.3 54.6 1.0
CA B:CYS463 4.3 64.5 1.0
CA B:ASN461 4.3 68.7 1.0
N B:ASN461 4.5 67.8 1.0
CA B:CYS476 4.5 50.6 1.0
N B:GLY459 4.6 59.6 1.0
N B:ALA458 4.7 58.5 1.0
C B:CYS457 4.7 58.0 1.0
C B:ASN461 4.8 67.4 1.0
N B:ASP462 4.8 73.7 1.0
CA B:CYS473 4.9 53.9 1.0
CA B:GLY459 5.0 65.1 1.0

Reference:

W.H.Hudson, B.R.Kossmann, I.M.De Vera, S.W.Chuo, E.R.Weikum, G.N.Eick, J.W.Thornton, I.N.Ivanov, D.J.Kojetin, E.A.Ortlund. Distal Substitutions Drive Divergent Dna Specificity Among Paralogous Transcription Factors Through Subdivision of Conformational Space. Proc.Natl.Acad.Sci.Usa V. 113 326 2016.
ISSN: ESSN 1091-6490
PubMed: 26715749
DOI: 10.1073/PNAS.1518960113
Page generated: Wed Dec 16 06:06:37 2020

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