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Atomistry » Zinc » PDB 5onk-5phh » 5oqw | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 5onk-5phh » 5oqw » |
Zinc in PDB 5oqw: Xiap in Complex with Small MoleculeEnzymatic activity of Xiap in Complex with Small Molecule
All present enzymatic activity of Xiap in Complex with Small Molecule:
2.3.2.27; Protein crystallography data
The structure of Xiap in Complex with Small Molecule, PDB code: 5oqw
was solved by
P.A.Williams,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5oqw:
The structure of Xiap in Complex with Small Molecule also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Xiap in Complex with Small Molecule
(pdb code 5oqw). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Xiap in Complex with Small Molecule, PDB code: 5oqw: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 5oqwGo back to![]() ![]()
Zinc binding site 1 out
of 2 in the Xiap in Complex with Small Molecule
![]() Mono view ![]() Stereo pair view
Zinc binding site 2 out of 2 in 5oqwGo back to![]() ![]()
Zinc binding site 2 out
of 2 in the Xiap in Complex with Small Molecule
![]() Mono view ![]() Stereo pair view
Reference:
G.A.Ward,
E.J.Lewis,
J.S.Ahn,
C.N.Johnson,
J.F.Lyons,
V.Martins,
J.M.Munck,
S.J.Rich,
T.Smyth,
N.T.Thompson,
P.A.Williams,
N.E.Wilsher,
N.G.Wallis,
G.Chessari.
ASTX660, A Novel Non-Peptidomimetic Antagonist of CIAP1/2 and Xiap, Potently Induces Tnf Alpha-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth. Mol. Cancer Ther. V. 17 1381 2018.
Page generated: Sun Oct 27 23:46:44 2024
ISSN: ESSN 1538-8514 PubMed: 29695633 DOI: 10.1158/1535-7163.MCT-17-0848 |
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