Zinc in PDB 5bqk: Crystal Structure of C-Terminal Domain of ICP27 Protein From Hsv-1

The structure of Crystal Structure of C-Terminal Domain of ICP27 Protein From Hsv-1, PDB code: 5bqk was solved by V.Patel, V.Rajakannan, S.Dahlroth, P.Nordlund, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	23.80 / 2.00
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	156.983, 120.335, 79.037, 90.00, 100.46, 90.00
R / Rfree (%)	21.7 / 24.9

The binding sites of Zinc atom in the Crystal Structure of C-Terminal Domain of ICP27 Protein From Hsv-1 (pdb code 5bqk). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Crystal Structure of C-Terminal Domain of ICP27 Protein From Hsv-1, PDB code: 5bqk:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Crystal Structure of C-Terminal Domain of ICP27 Protein From Hsv-1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of C-Terminal Domain of ICP27 Protein From Hsv-1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn601 b:33.5 occ:1.00 NE2 A:HIS479 2.0 30.4 1.0 SG A:CYS400 2.1 33.4 1.0 SG A:CYS488 2.4 33.0 1.0 SG A:CYS483 2.4 35.8 1.0 CD2 A:HIS479 2.9 33.4 1.0 CE1 A:HIS479 3.0 26.6 1.0 CB A:CYS488 3.1 29.0 1.0 CB A:CYS400 3.2 33.6 1.0 CB A:CYS483 3.4 37.7 1.0 CG A:HIS479 4.1 28.5 1.0 ND1 A:HIS479 4.1 25.2 1.0 CA A:CYS400 4.4 33.6 1.0 O A:HOH807 4.5 27.0 1.0 C A:CYS400 4.5 32.5 1.0 CA A:CYS488 4.6 30.6 1.0 N A:TYR401 4.7 30.2 1.0 O A:HOH782 4.7 40.2 1.0 CA A:CYS483 4.8 37.5 1.0 CB A:SER485 4.9 36.7 1.0 O A:CYS400 5.0 33.8 1.0

Zinc binding site 2 out of 3 in the Crystal Structure of C-Terminal Domain of ICP27 Protein From Hsv-1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of C-Terminal Domain of ICP27 Protein From Hsv-1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn601 b:35.8 occ:1.00 SG B:CYS400 1.9 32.6 1.0 NE2 B:HIS479 2.0 31.7 1.0 SG B:CYS488 2.4 39.1 1.0 SG B:CYS483 2.5 42.0 1.0 CE1 B:HIS479 2.7 31.7 1.0 CD2 B:HIS479 3.2 36.2 1.0 CB B:CYS400 3.2 34.9 1.0 CB B:CYS488 3.2 39.5 1.0 CB B:CYS483 3.3 43.6 1.0 ND1 B:HIS479 3.9 36.3 1.0 CG B:HIS479 4.2 31.4 1.0 CA B:CYS400 4.4 35.4 1.0 O B:HOH787 4.4 31.1 1.0 C B:CYS400 4.4 35.8 1.0 O B:HOH783 4.5 36.3 1.0 N B:TYR401 4.6 34.6 1.0 O B:HOH778 4.6 42.0 1.0 CA B:CYS488 4.6 39.0 1.0 CA B:CYS483 4.8 44.5 1.0 O B:CYS400 4.9 34.1 1.0

Zinc binding site 3 out of 3 in the Crystal Structure of C-Terminal Domain of ICP27 Protein From Hsv-1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of C-Terminal Domain of ICP27 Protein From Hsv-1 within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn601 b:37.8 occ:1.00 NE2 C:HIS479 2.0 37.0 1.0 SG C:CYS400 2.2 36.9 1.0 SG C:CYS488 2.3 33.7 1.0 SG C:CYS483 2.4 38.6 1.0 CE1 C:HIS479 3.0 38.4 1.0 CD2 C:HIS479 3.0 35.6 1.0 CB C:CYS488 3.2 32.6 1.0 CB C:CYS483 3.3 40.9 1.0 CB C:CYS400 3.4 35.5 1.0 ND1 C:HIS479 4.1 38.5 1.0 CG C:HIS479 4.1 35.2 1.0 O C:HOH770 4.4 33.4 1.0 CA C:CYS400 4.6 37.4 1.0 C C:CYS400 4.6 37.3 1.0 CA C:CYS488 4.6 31.5 1.0 N C:TYR401 4.7 37.7 1.0 O C:HOH759 4.7 36.5 1.0 O C:HOH755 4.8 32.7 1.0 CA C:CYS483 4.8 40.7 1.0 CB C:SER485 4.8 37.3 1.0 O C:CYS400 5.0 36.7 1.0

V.Patel, S.L.Dahlroth, V.Rajakannan, H.T.Ho, T.Cornvik, P.Nordlund. Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein From Herpes Simplex Virus 1. J.Virol. V. 89 8828 2015.
ISSN: ESSN 1098-5514
PubMed: 26085142
DOI: 10.1128/JVI.00441-15