Zinc in PDB 5aho: Crystal Structure of Human 5' Exonuclease Apollo

The structure of Crystal Structure of Human 5' Exonuclease Apollo, PDB code: 5aho was solved by C.K.Allerston, M.Vollmar, T.Krojer, A.C.W.Pike, J.A.Newman, E.Carpenter, A.Quigley, P.Mahajan, F.Von Delft, C.Bountra, C.H.Arrowsmith, A.Edwards, O.Gileadi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.591 / 2.16
Space group	P 41 3 2
Cell size a, b, c (Å), α, β, γ (°)	143.092, 143.092, 143.092, 90.00, 90.00, 90.00
R / Rfree (%)	20.59 / 22.57

The binding sites of Zinc atom in the Crystal Structure of Human 5' Exonuclease Apollo (pdb code 5aho). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human 5' Exonuclease Apollo, PDB code: 5aho:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human 5' Exonuclease Apollo


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human 5' Exonuclease Apollo within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1320 b:41.3 occ:0.76 O A:HOH2006 2.2 30.2 1.0 O2 A:TLA1319 2.2 28.5 1.0 OD2 A:ASP120 2.2 23.7 1.0 NE2 A:HIS36 2.3 24.7 1.0 O41 A:TLA1319 2.3 36.1 1.0 OD2 A:ASP35 2.7 32.7 1.0 CG A:ASP120 3.0 21.6 1.0 OD1 A:ASP120 3.2 22.4 1.0 CE1 A:HIS36 3.2 24.3 1.0 CD2 A:HIS36 3.2 25.2 1.0 C4 A:TLA1319 3.3 42.9 1.0 C2 A:TLA1319 3.3 31.5 1.0 ZN A:ZN1321 3.5 27.2 1.0 C3 A:TLA1319 3.5 35.4 1.0 CG A:ASP35 3.7 38.5 1.0 O11 A:TLA1319 3.7 25.0 1.0 C1 A:TLA1319 3.8 28.6 1.0 O A:HOH2145 3.8 28.3 1.0 ND2 A:ASN2 3.8 34.4 1.0 OD1 A:ASP35 3.9 40.1 1.0 CE1 A:HIS276 4.3 23.5 1.0 ND1 A:HIS36 4.3 22.8 1.0 NE2 A:HIS31 4.3 20.5 1.0 CG A:HIS36 4.4 23.2 1.0 CE1 A:HIS31 4.4 20.7 1.0 O4 A:TLA1319 4.4 49.6 1.0 CB A:ASP120 4.5 19.5 1.0 CB A:ASN2 4.6 30.4 1.0 CG A:ASN2 4.6 35.5 1.0 O1 A:TLA1319 4.8 30.6 1.0 O3 A:TLA1319 4.9 48.8 1.0 NE2 A:HIS276 5.0 24.0 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human 5' Exonuclease Apollo


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human 5' Exonuclease Apollo within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1321 b:27.2 occ:1.00 O11 A:TLA1319 2.1 25.0 1.0 ND1 A:HIS33 2.1 22.5 1.0 NE2 A:HIS31 2.2 20.5 1.0 OD2 A:ASP120 2.3 23.7 1.0 NE2 A:HIS99 2.3 20.3 1.0 O2 A:TLA1319 2.5 28.5 1.0 C1 A:TLA1319 3.0 28.6 1.0 CE1 A:HIS33 3.0 23.8 1.0 CD2 A:HIS31 3.1 20.7 1.0 CE1 A:HIS31 3.1 20.7 1.0 CD2 A:HIS99 3.2 20.4 1.0 C2 A:TLA1319 3.2 31.5 1.0 CG A:HIS33 3.2 24.0 1.0 CE1 A:HIS99 3.3 21.3 1.0 CG A:ASP120 3.3 21.6 1.0 ZN A:ZN1320 3.5 41.3 0.8 CB A:HIS33 3.6 24.3 1.0 CB A:ASP120 3.6 19.5 1.0 NE2 A:HIS36 4.0 24.7 1.0 O1 A:TLA1319 4.1 30.6 1.0 NE2 A:HIS33 4.2 23.7 1.0 ND1 A:HIS31 4.2 20.0 1.0 CG A:HIS31 4.2 18.2 1.0 CG A:HIS99 4.3 19.6 1.0 CD2 A:HIS33 4.3 24.0 1.0 ND1 A:HIS99 4.3 19.5 1.0 CD2 A:HIS36 4.3 25.2 1.0 CE1 A:HIS276 4.4 23.5 1.0 OD1 A:ASP120 4.4 22.4 1.0 O41 A:TLA1319 4.5 36.1 1.0 C3 A:TLA1319 4.6 35.4 1.0 O A:HOH2175 4.7 23.9 1.0 NE2 A:HIS276 4.7 24.0 1.0 C4 A:TLA1319 4.9 42.9 1.0

C.K.Allerston, M.Vollmar, T.Krojer, A.C.W.Pike, J.A.Newman, E.Carpenter, A.Quigley, P.Mahajan, F.Von Delft, C.Bountra, C.H.Arrowsmith, A.Edwards, O.Gileadi. Crystal Structure of Human 5' Exonuclease Apollo To Be Published.