Zinc in PDB 4zs4: Crystal Structure of the Inactive Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A (D756A) Complexed with Atp

All present enzymatic activity of Crystal Structure of the Inactive Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A (D756A) Complexed with Atp:
2.7.11.7;

The structure of Crystal Structure of the Inactive Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A (D756A) Complexed with Atp, PDB code: 4zs4 was solved by Q.Ye, Z.Jia, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.40
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	83.207, 109.744, 77.845, 90.00, 90.00, 90.00
R / Rfree (%)	17.9 / 22.3

The binding sites of Zinc atom in the Crystal Structure of the Inactive Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A (D756A) Complexed with Atp (pdb code 4zs4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Inactive Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A (D756A) Complexed with Atp, PDB code: 4zs4:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of the Inactive Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A (D756A) Complexed with Atp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Inactive Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A (D756A) Complexed with Atp within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn902 b:32.1 occ:1.00 NE2 A:HIS794 2.0 22.3 1.0 ND1 A:HIS742 2.1 29.8 1.0 SG A:CYS800 2.3 30.7 1.0 SG A:CYS796 2.4 43.0 1.0 CE1 A:HIS794 2.9 23.9 1.0 CE1 A:HIS742 3.0 30.2 1.0 CD2 A:HIS794 3.0 24.2 1.0 CB A:CYS800 3.1 26.8 1.0 CG A:HIS742 3.2 26.6 1.0 CB A:CYS796 3.3 38.5 1.0 CA A:CYS796 3.4 38.4 1.0 CB A:HIS742 3.6 23.7 1.0 ND1 A:HIS794 4.1 23.9 1.0 N A:CYS796 4.1 37.4 1.0 NE2 A:HIS742 4.1 29.9 1.0 CG A:HIS794 4.1 25.3 1.0 CD2 A:HIS742 4.2 28.6 1.0 CA A:CYS800 4.5 27.1 1.0 C A:CYS796 4.5 40.9 1.0 N A:ASN797 4.6 36.6 1.0 CD1 A:LEU805 4.7 37.0 1.0 C A:LYS795 4.7 39.3 1.0 O A:LYS795 4.7 37.2 1.0 CB A:LEU805 5.0 41.5 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of the Inactive Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A (D756A) Complexed with Atp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Inactive Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A (D756A) Complexed with Atp within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn902 b:23.2 occ:1.00 NE2 B:HIS794 2.0 21.9 1.0 ND1 B:HIS742 2.1 20.5 1.0 SG B:CYS800 2.3 23.4 1.0 SG B:CYS796 2.3 26.1 1.0 CE1 B:HIS742 3.0 20.9 1.0 CE1 B:HIS794 3.0 22.8 1.0 CB B:CYS800 3.0 23.6 1.0 CD2 B:HIS794 3.1 22.8 1.0 CG B:HIS742 3.2 19.5 1.0 CB B:CYS796 3.2 24.1 1.0 CA B:CYS796 3.3 24.8 1.0 CB B:HIS742 3.6 18.2 1.0 N B:CYS796 4.1 24.9 1.0 NE2 B:HIS742 4.1 20.3 1.0 ND1 B:HIS794 4.1 23.0 1.0 CG B:HIS794 4.2 23.5 1.0 CD2 B:HIS742 4.2 19.9 1.0 CA B:CYS800 4.4 23.4 1.0 C B:CYS796 4.5 25.4 1.0 N B:ASN797 4.5 24.4 1.0 CD1 B:LEU805 4.6 30.8 1.0 C B:LYS795 4.7 26.9 1.0 O B:LYS795 4.7 27.6 1.0 CB B:LEU805 4.9 30.8 1.0

Y.Yang, Q.Ye, Z.Jia, G.P.Cote. Characterization of the Catalytic and Nucleotide Binding Properties of the Alpha-Kinase Domain of Dictyostelium Myosin-II Heavy Chain Kinase A. J.Biol.Chem. V. 290 23935 2015.
ISSN: ESSN 1083-351X
PubMed: 26260792
DOI: 10.1074/JBC.M115.672410