Zinc in PDB 4zme: Crystal Structure of the Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A in Complex with Adenosine

All present enzymatic activity of Crystal Structure of the Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A in Complex with Adenosine:
2.7.11.7;

The structure of Crystal Structure of the Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A in Complex with Adenosine, PDB code: 4zme was solved by Q.Ye, Z.Jia, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	79.56 / 1.98
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	83.194, 111.288, 79.560, 90.00, 90.00, 90.00
R / Rfree (%)	21.4 / 23.6

The binding sites of Zinc atom in the Crystal Structure of the Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A in Complex with Adenosine (pdb code 4zme). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A in Complex with Adenosine, PDB code: 4zme:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of the Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A in Complex with Adenosine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A in Complex with Adenosine within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:30.1 occ:1.00 NE2 A:HIS794 2.0 26.4 1.0 ND1 A:HIS742 2.2 30.1 1.0 SG A:CYS800 2.3 27.9 1.0 SG A:CYS796 2.4 32.2 1.0 CE1 A:HIS794 2.9 25.0 1.0 CD2 A:HIS794 3.0 26.1 1.0 CE1 A:HIS742 3.1 29.8 1.0 CG A:HIS742 3.2 27.8 1.0 CB A:CYS800 3.2 27.6 1.0 CB A:CYS796 3.3 34.8 1.0 CA A:CYS796 3.4 35.8 1.0 CB A:HIS742 3.5 25.4 1.0 ND1 A:HIS794 4.1 27.4 1.0 N A:CYS796 4.1 35.9 1.0 CG A:HIS794 4.2 26.5 1.0 NE2 A:HIS742 4.2 29.6 1.0 CD2 A:HIS742 4.2 30.0 1.0 CA A:CYS800 4.6 28.6 1.0 C A:CYS796 4.6 38.8 1.0 N A:ASN797 4.6 36.3 1.0 O A:HOH1209 4.6 36.7 1.0 C A:LYS795 4.8 36.3 1.0 CD1 A:LEU805 4.8 26.0 1.0 O A:HOH1229 4.8 45.4 1.0 O A:LYS795 4.9 35.8 1.0 CD1 A:LEU809 5.0 47.9 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of the Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A in Complex with Adenosine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Alpha-Kinase Domain of Myosin-II Heavy Chain Kinase A in Complex with Adenosine within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn901 b:31.5 occ:1.00 SG B:CYS800 1.9 26.2 1.0 NE2 B:HIS794 2.1 29.9 1.0 ND1 B:HIS742 2.1 31.6 1.0 SG B:CYS796 2.4 37.5 1.0 CE1 B:HIS742 3.0 32.3 1.0 CE1 B:HIS794 3.0 28.9 1.0 CD2 B:HIS794 3.1 32.5 1.0 CG B:HIS742 3.2 29.2 1.0 CB B:CYS800 3.2 31.2 1.0 CB B:CYS796 3.3 39.8 1.0 CA B:CYS796 3.4 37.4 1.0 CB B:HIS742 3.5 27.5 1.0 NE2 B:HIS742 4.1 31.3 1.0 ND1 B:HIS794 4.2 31.9 1.0 N B:CYS796 4.2 42.0 1.0 CD2 B:HIS742 4.2 29.7 1.0 CG B:HIS794 4.2 32.1 1.0 CA B:CYS800 4.5 31.8 1.0 N B:ASN797 4.5 34.3 1.0 C B:CYS796 4.5 38.5 1.0 CD1 B:LEU805 4.7 29.2 1.0 O B:HOH1040 4.8 40.4 1.0 C B:LYS795 4.8 42.8 1.0 CD1 B:LEU809 4.9 78.2 1.0 O B:LYS795 5.0 42.9 1.0

Y.Yang, Q.Ye, Z.Jia, G.P.Cote. Characterization of the Catalytic and Nucleotide Binding Properties of the Alpha-Kinase Domain of Dictyostelium Myosin-II Heavy Chain Kinase A. J.Biol.Chem. V. 290 23935 2015.
ISSN: ESSN 1083-351X
PubMed: 26260792
DOI: 10.1074/JBC.M115.672410