Atomistry » Zinc » PDB 4xgl-4xnw » 4xli
Atomistry »
  Zinc »
    PDB 4xgl-4xnw »
      4xli »

Zinc in PDB 4xli: Crystal Structure of ABL2/Arg Kinase in Complex with Dasatinib

Enzymatic activity of Crystal Structure of ABL2/Arg Kinase in Complex with Dasatinib

All present enzymatic activity of Crystal Structure of ABL2/Arg Kinase in Complex with Dasatinib:
2.7.10.2;

Protein crystallography data

The structure of Crystal Structure of ABL2/Arg Kinase in Complex with Dasatinib, PDB code: 4xli was solved by B.H.Ha, T.J.Boggon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.50 / 2.50
Space group P 65
Cell size a, b, c (Å), α, β, γ (°) 109.688, 109.688, 121.520, 90.00, 90.00, 120.00
R / Rfree (%) 15.4 / 20.5

Other elements in 4xli:

The structure of Crystal Structure of ABL2/Arg Kinase in Complex with Dasatinib also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of ABL2/Arg Kinase in Complex with Dasatinib (pdb code 4xli). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of ABL2/Arg Kinase in Complex with Dasatinib, PDB code: 4xli:

Zinc binding site 1 out of 1 in 4xli

Go back to Zinc Binding Sites List in 4xli
Zinc binding site 1 out of 1 in the Crystal Structure of ABL2/Arg Kinase in Complex with Dasatinib


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of ABL2/Arg Kinase in Complex with Dasatinib within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn602

b:37.1
occ:1.00
OE2 B:GLU398 1.8 30.9 1.0
OE2 A:GLU398 2.0 36.1 1.0
ND1 A:HIS536 2.1 33.2 1.0
ND1 B:HIS536 2.2 34.9 1.0
OE1 A:GLU398 2.6 34.2 1.0
CD A:GLU398 2.6 34.3 1.0
CD B:GLU398 2.7 34.0 1.0
CE1 A:HIS536 2.8 38.3 1.0
OE1 B:GLU398 2.9 34.4 1.0
CE1 B:HIS536 2.9 36.1 1.0
CG B:HIS536 3.2 36.2 1.0
CG A:HIS536 3.2 41.3 1.0
CB B:HIS536 3.7 35.4 1.0
CB A:HIS536 3.8 35.2 1.0
NE2 A:HIS536 4.0 39.6 1.0
NE2 B:HIS536 4.0 33.9 1.0
CG B:GLU398 4.1 30.7 1.0
CG A:GLU398 4.1 30.2 1.0
CD2 A:HIS536 4.2 37.6 1.0
CD2 B:HIS536 4.2 37.7 1.0
N B:GLN537 4.3 29.4 1.0
O A:ALA533 4.3 47.1 1.0
O B:ALA533 4.4 33.8 1.0
N A:GLN537 4.5 24.8 1.0
C B:HIS536 4.6 30.9 1.0
C A:HIS536 4.7 30.3 1.0
CA B:HIS536 4.8 33.2 1.0
CA B:GLN537 4.8 30.6 1.0
CA A:GLN537 4.9 27.8 1.0
CA A:HIS536 4.9 33.4 1.0

Reference:

B.H.Ha, M.A.Simpson, A.J.Koleske, T.J.Boggon. Crystal Structure of ABL2/Arg Kinase in Complex with Dasatinib Acta Crystallogr.,Sect.F 2015.
ISSN: ESSN 2053-230X
Page generated: Wed Dec 16 05:54:35 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy