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Zinc in PDB 4w5i: Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7- Phenyl-1,2,3,4,5,6-Hexahydro-1,6- Naphthyridin-5-OneEnzymatic activity of Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7- Phenyl-1,2,3,4,5,6-Hexahydro-1,6- Naphthyridin-5-One
All present enzymatic activity of Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7- Phenyl-1,2,3,4,5,6-Hexahydro-1,6- Naphthyridin-5-One:
2.4.2.30; Protein crystallography data
The structure of Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7- Phenyl-1,2,3,4,5,6-Hexahydro-1,6- Naphthyridin-5-One, PDB code: 4w5i
was solved by
T.Haikarainen,
L.Lehtio,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7- Phenyl-1,2,3,4,5,6-Hexahydro-1,6- Naphthyridin-5-One
(pdb code 4w5i). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7- Phenyl-1,2,3,4,5,6-Hexahydro-1,6- Naphthyridin-5-One, PDB code: 4w5i: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 4w5iGo back to Zinc Binding Sites List in 4w5i
Zinc binding site 1 out
of 2 in the Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7- Phenyl-1,2,3,4,5,6-Hexahydro-1,6- Naphthyridin-5-One
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 4w5iGo back to Zinc Binding Sites List in 4w5i
Zinc binding site 2 out
of 2 in the Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7- Phenyl-1,2,3,4,5,6-Hexahydro-1,6- Naphthyridin-5-One
Mono view Stereo pair view
Reference:
K.Kumpan,
A.Nathubhai,
C.Zhang,
P.J.Wood,
M.D.Lloyd,
A.S.Thompson,
T.Haikarainen,
L.Lehtio,
M.D.Threadgill.
Structure-Based Design, Synthesis and Evaluation in Vitro of Arylnaphthyridinones, Arylpyridopyrimidinones and Their Tetrahydro Derivatives As Inhibitors of the Tankyrases. Bioorg.Med.Chem. V. 23 3013 2015.
Page generated: Wed Dec 16 05:50:34 2020
ISSN: ESSN 1464-3391 PubMed: 26026769 DOI: 10.1016/J.BMC.2015.05.005 |
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