Atomistry » Zinc » PDB 4r5a-4rkg » 4r5v
Atomistry »
  Zinc »
    PDB 4r5a-4rkg »
      4r5v »

Zinc in PDB 4r5v: Structure of the M1 Alanylaminopeptidase From Malaria Complexed with A Hydroxamic Acid-Based Inhibitor

Protein crystallography data

The structure of Structure of the M1 Alanylaminopeptidase From Malaria Complexed with A Hydroxamic Acid-Based Inhibitor, PDB code: 4r5v was solved by N.Drinkwater, S.Mcgowan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.51 / 2.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 75.222, 109.593, 118.698, 90.00, 90.00, 90.00
R / Rfree (%) 18.1 / 22.2

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of the M1 Alanylaminopeptidase From Malaria Complexed with A Hydroxamic Acid-Based Inhibitor (pdb code 4r5v). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of the M1 Alanylaminopeptidase From Malaria Complexed with A Hydroxamic Acid-Based Inhibitor, PDB code: 4r5v:

Zinc binding site 1 out of 1 in 4r5v

Go back to Zinc Binding Sites List in 4r5v
Zinc binding site 1 out of 1 in the Structure of the M1 Alanylaminopeptidase From Malaria Complexed with A Hydroxamic Acid-Based Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the M1 Alanylaminopeptidase From Malaria Complexed with A Hydroxamic Acid-Based Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1101

b:20.6
occ:1.00
OE1 A:GLU519 2.1 16.2 1.0
NE2 A:HIS500 2.1 18.4 1.0
NE2 A:HIS496 2.1 18.0 1.0
O A:R5V1102 2.1 26.5 1.0
OAL A:R5V1102 2.6 33.4 1.0
CD A:GLU519 2.8 20.6 1.0
OE2 A:GLU519 2.8 19.4 1.0
C A:R5V1102 2.9 32.2 1.0
CE1 A:HIS500 3.0 20.7 1.0
CD2 A:HIS500 3.1 21.5 1.0
CD2 A:HIS496 3.1 19.1 1.0
CE1 A:HIS496 3.1 18.1 1.0
NAK A:R5V1102 3.1 31.4 1.0
O A:HOH1358 3.4 28.0 1.0
OH A:TYR580 4.1 14.9 1.0
ND1 A:HIS500 4.2 17.3 1.0
CG A:HIS500 4.2 16.4 1.0
ND1 A:HIS496 4.2 17.0 1.0
CE2 A:TYR580 4.2 17.2 1.0
CG A:HIS496 4.2 18.9 1.0
OE1 A:GLU463 4.2 36.6 1.0
CA A:R5V1102 4.2 35.3 1.0
CG A:GLU519 4.3 18.9 1.0
N A:R5V1102 4.5 38.1 1.0
CZ A:TYR580 4.6 16.4 1.0
OE1 A:GLU497 4.6 22.2 1.0
CG2 A:THR522 4.7 17.1 1.0
CA A:GLU519 4.8 18.6 1.0
CB A:GLU519 4.9 16.6 1.0
CB A:THR522 4.9 20.1 1.0
CD A:GLU463 4.9 39.7 1.0
OE2 A:GLU497 5.0 24.6 1.0

Reference:

S.N.Mistry, N.Drinkwater, C.Ruggeri, K.Kannan Sivaraman, S.Loganathan, S.Fletcher, M.Drag, A.Paiardini, V.M.Avery, P.J.Scammells, S.Mcgowan. A Two-Pronged Attack: Dual Inhibition of Plasmodium Falciparum M1 and M17 Metalloaminopeptidases By A Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem. 2014.
ISSN: ISSN 0022-2623
PubMed: 25299353
DOI: 10.1021/JM501323A
Page generated: Wed Dec 16 05:44:56 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy