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Atomistry » Zinc » PDB 4qqr-4r5t » 4quo » |
Zinc in PDB 4quo: Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe(3-CH2NH2)Enzymatic activity of Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe(3-CH2NH2)
All present enzymatic activity of Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe(3-CH2NH2):
3.4.11.2; Protein crystallography data
The structure of Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe(3-CH2NH2), PDB code: 4quo
was solved by
B.Nocek,
R.Mulligan,
A.Joachimak,
S.Vassiliou,
L.Berlicki,
A.Mucha,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe(3-CH2NH2)
(pdb code 4quo). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe(3-CH2NH2), PDB code: 4quo: Zinc binding site 1 out of 1 in 4quoGo back to Zinc Binding Sites List in 4quo
Zinc binding site 1 out
of 1 in the Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe(3-CH2NH2)
Mono view Stereo pair view
Reference:
S.Vassiliou,
E.Weglarz-Tomczak,
L.Berlicki,
M.Paweczak,
B.Nocek,
R.Mulligan,
A.Joachimiak,
A.Mucha.
Structure-Guided, Single-Point Modifications in the Phosphinic Dipeptide Structure Yield Highly Potent and Selective Inhibitors of Neutral Aminopeptidases. J.Med.Chem. V. 57 8140 2014.
Page generated: Wed Dec 16 05:44:21 2020
ISSN: ISSN 0022-2623 PubMed: 25192493 DOI: 10.1021/JM501071F |
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