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Zinc in PDB 4qme: Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe
Enzymatic activity of Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe
All present enzymatic activity of Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe:
3.4.11.2;
3.4.11.2;
Protein crystallography data
The structure of Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe, PDB code: 4qme
was solved by
B.Nocek,
S.Vassilious,
R.Mulligan,
L.Berlicki,
A.Mucha,
A.Joachimiak,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 32.33 / 1.60 |
| Space group | H 3 |
| Cell size a, b, c (Å), α, β, γ (°) | 224.000, 224.000, 57.872, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 14.4 / 17.2 |
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe
(pdb code 4qme). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe, PDB code: 4qme:
In total only one binding site of Zinc was determined in the Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe, PDB code: 4qme:
Zinc binding site 1 out of 1 in 4qme
Go back to
Zinc Binding Sites List in 4qme
Zinc binding site 1 out
of 1 in the Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure of Aminopeptidase N in Complex with the Phosphinic Dipeptide Analogue Ll-(R,S)-Hphep[CH2]Phe within 5.0Å range:
|
Reference:
S.Vassiliou,
E.Weglarz-Tomczak,
L.Berlicki,
M.Paweczak,
B.Nocek,
R.Mulligan,
A.Joachimiak,
A.Mucha.
Structure-Guided, Single-Point Modifications in the Phosphinic Dipeptide Structure Yield Highly Potent and Selective Inhibitors of Neutral Aminopeptidases. J.Med.Chem. V. 57 8140 2014.
ISSN: ISSN 0022-2623
PubMed: 25192493
DOI: 10.1021/JM501071F
Page generated: Sun Oct 27 06:39:55 2024
ISSN: ISSN 0022-2623
PubMed: 25192493
DOI: 10.1021/JM501071F
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