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Zinc in PDB 4q8w: Trna-Guanine Transglycosylase (Tgt) in Complex with 4-[2-({6-Amino-8- Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino)Ethyl]Benzoic Acid

Enzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Complex with 4-[2-({6-Amino-8- Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino)Ethyl]Benzoic Acid

All present enzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Complex with 4-[2-({6-Amino-8- Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino)Ethyl]Benzoic Acid:
2.4.2.29;

Protein crystallography data

The structure of Trna-Guanine Transglycosylase (Tgt) in Complex with 4-[2-({6-Amino-8- Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino)Ethyl]Benzoic Acid, PDB code: 4q8w was solved by M.Neeb, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 70.26 / 1.14
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 89.830, 64.680, 70.680, 90.00, 96.28, 90.00
R / Rfree (%) 13.4 / 15

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna-Guanine Transglycosylase (Tgt) in Complex with 4-[2-({6-Amino-8- Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino)Ethyl]Benzoic Acid (pdb code 4q8w). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase (Tgt) in Complex with 4-[2-({6-Amino-8- Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino)Ethyl]Benzoic Acid, PDB code: 4q8w:

Zinc binding site 1 out of 1 in 4q8w

Go back to Zinc Binding Sites List in 4q8w
Zinc binding site 1 out of 1 in the Trna-Guanine Transglycosylase (Tgt) in Complex with 4-[2-({6-Amino-8- Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino)Ethyl]Benzoic Acid


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna-Guanine Transglycosylase (Tgt) in Complex with 4-[2-({6-Amino-8- Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino)Ethyl]Benzoic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:12.7
occ:1.00
 ND1 A:HIS349 2.1 12.3 1.0
SG A:CYS323 2.3 12.5 1.0
SG A:CYS320 2.3 11.9 1.0
SG A:CYS318 2.3 14.3 1.0
CE1 A:HIS349 2.9 12.7 1.0
CG A:HIS349 3.2 11.2 1.0
CB A:CYS323 3.3 12.8 1.0
CB A:CYS318 3.3 14.8 1.0
CB A:CYS320 3.4 12.8 1.0
CB A:HIS349 3.7 11.0 1.0
N A:CYS323 3.9 12.1 1.0
CA A:HIS349 4.1 10.7 1.0
NE2 A:HIS349 4.1 12.4 1.0
N A:CYS320 4.1 14.8 1.0
CA A:CYS323 4.2 12.5 1.0
CA A:CYS320 4.2 13.7 1.0
CD2 A:HIS349 4.3 11.5 1.0
O A:HIS349 4.5 10.6 1.0
CA A:CYS318 4.6 15.1 1.0
O A:CYS320 4.6 13.2 1.0
C A:CYS318 4.7 16.1 1.0
C A:CYS320 4.7 12.7 1.0
C A:HIS349 4.7 10.3 1.0
CB A:VAL322 4.7 11.9 1.0
O A:CYS318 4.8 16.6 1.0
C A:VAL322 4.9 12.6 1.0

Reference:

M.Neeb, C.Hohn, A.Heine, F.Diederich, G.Klebe. Addressing A New Subpocket of Tgt By Elongated 2-Amino-Lin-Benzoguanines To Be Published.
Page generated: Sun Oct 27 06:24:19 2024

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