|
Atomistry » Zinc » PDB 4q30-4q8u » 4q4q | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 4q30-4q8u » 4q4q » |
Zinc in PDB 4q4q: Trna-Guanine Transglycosylase (Tgt) in Complex with 2-[(Thiophen-2- Ylmethyl)Amino]-1H,7H,8H-Imidazo[4,5-G]Quinazolin-8-OneEnzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Complex with 2-[(Thiophen-2- Ylmethyl)Amino]-1H,7H,8H-Imidazo[4,5-G]Quinazolin-8-One
All present enzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Complex with 2-[(Thiophen-2- Ylmethyl)Amino]-1H,7H,8H-Imidazo[4,5-G]Quinazolin-8-One:
2.4.2.29; Protein crystallography data
The structure of Trna-Guanine Transglycosylase (Tgt) in Complex with 2-[(Thiophen-2- Ylmethyl)Amino]-1H,7H,8H-Imidazo[4,5-G]Quinazolin-8-One, PDB code: 4q4q
was solved by
M.Neeb,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Trna-Guanine Transglycosylase (Tgt) in Complex with 2-[(Thiophen-2- Ylmethyl)Amino]-1H,7H,8H-Imidazo[4,5-G]Quinazolin-8-One
(pdb code 4q4q). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase (Tgt) in Complex with 2-[(Thiophen-2- Ylmethyl)Amino]-1H,7H,8H-Imidazo[4,5-G]Quinazolin-8-One, PDB code: 4q4q: Zinc binding site 1 out of 1 in 4q4qGo back to Zinc Binding Sites List in 4q4q
Zinc binding site 1 out
of 1 in the Trna-Guanine Transglycosylase (Tgt) in Complex with 2-[(Thiophen-2- Ylmethyl)Amino]-1H,7H,8H-Imidazo[4,5-G]Quinazolin-8-One
Mono view Stereo pair view
Reference:
M.Neeb,
M.Betz,
A.Heine,
L.J.Barandun,
C.Hohn,
F.Diederich,
G.Klebe.
Beyond Affinity: Enthalpy-Entropy Factorization Unravels Complexity of A Flat Structure-Activity Relationship For Inhibition of A Trna-Modifying Enzyme. J.Med.Chem. V. 57 5566 2014.
Page generated: Wed Dec 16 05:42:35 2020
ISSN: ISSN 0022-2623 PubMed: 24960372 DOI: 10.1021/JM5006868 |
Last articlesZn in 8WB0Zn in 8WAX Zn in 8WAU Zn in 8WAZ Zn in 8WAY Zn in 8WAV Zn in 8WAW Zn in 8WAT Zn in 8W7M Zn in 8WD3 |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |