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Atomistry » Zinc » PDB 4q30-4q8u » 4q4p | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 4q30-4q8u » 4q4p » |
Zinc in PDB 4q4p: Trna-Guanine Transglycosylase (Tgt) in Complex with 2-{[2-(Piperidin- 1-Yl)Ethyl]Amino}-3,5-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-OneEnzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Complex with 2-{[2-(Piperidin- 1-Yl)Ethyl]Amino}-3,5-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One
All present enzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Complex with 2-{[2-(Piperidin- 1-Yl)Ethyl]Amino}-3,5-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One:
2.4.2.29; Protein crystallography data
The structure of Trna-Guanine Transglycosylase (Tgt) in Complex with 2-{[2-(Piperidin- 1-Yl)Ethyl]Amino}-3,5-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One, PDB code: 4q4p
was solved by
M.Neeb,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4q4p:
The structure of Trna-Guanine Transglycosylase (Tgt) in Complex with 2-{[2-(Piperidin- 1-Yl)Ethyl]Amino}-3,5-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Trna-Guanine Transglycosylase (Tgt) in Complex with 2-{[2-(Piperidin- 1-Yl)Ethyl]Amino}-3,5-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One
(pdb code 4q4p). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase (Tgt) in Complex with 2-{[2-(Piperidin- 1-Yl)Ethyl]Amino}-3,5-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One, PDB code: 4q4p: Zinc binding site 1 out of 1 in 4q4pGo back to Zinc Binding Sites List in 4q4p
Zinc binding site 1 out
of 1 in the Trna-Guanine Transglycosylase (Tgt) in Complex with 2-{[2-(Piperidin- 1-Yl)Ethyl]Amino}-3,5-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One
Mono view Stereo pair view
Reference:
M.Neeb,
M.Betz,
A.Heine,
L.J.Barandun,
C.Hohn,
F.Diederich,
G.Klebe.
Beyond Affinity: Enthalpy-Entropy Factorization Unravels Complexity of A Flat Structure-Activity Relationship For Inhibition of A Trna-Modifying Enzyme. J.Med.Chem. V. 57 5566 2014.
Page generated: Sun Oct 27 06:16:03 2024
ISSN: ISSN 0022-2623 PubMed: 24960372 DOI: 10.1021/JM5006868 |
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