Atomistry » Zinc » PDB 4owp-4p9c » 4p3p
Atomistry »
  Zinc »
    PDB 4owp-4p9c »
      4p3p »

Zinc in PDB 4p3p: Structural Basis For Full-Spectrum Inhibition of Threonyl-Trna Synthetase By Borrelidin 3

Enzymatic activity of Structural Basis For Full-Spectrum Inhibition of Threonyl-Trna Synthetase By Borrelidin 3

All present enzymatic activity of Structural Basis For Full-Spectrum Inhibition of Threonyl-Trna Synthetase By Borrelidin 3:
6.1.1.3;

Protein crystallography data

The structure of Structural Basis For Full-Spectrum Inhibition of Threonyl-Trna Synthetase By Borrelidin 3, PDB code: 4p3p was solved by P.Fang, X.Yu, K.Chen, X.Chen, M.Guo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.80 / 2.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 94.534, 107.640, 109.623, 90.00, 90.00, 90.00
R / Rfree (%) 20 / 21.9

Zinc Binding Sites:

The binding sites of Zinc atom in the Structural Basis For Full-Spectrum Inhibition of Threonyl-Trna Synthetase By Borrelidin 3 (pdb code 4p3p). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structural Basis For Full-Spectrum Inhibition of Threonyl-Trna Synthetase By Borrelidin 3, PDB code: 4p3p:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4p3p

Go back to Zinc Binding Sites List in 4p3p
Zinc binding site 1 out of 2 in the Structural Basis For Full-Spectrum Inhibition of Threonyl-Trna Synthetase By Borrelidin 3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Basis For Full-Spectrum Inhibition of Threonyl-Trna Synthetase By Borrelidin 3 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn701

b:18.2
occ:1.00
NE2 A:HIS385 2.1 16.1 1.0
ND1 A:HIS511 2.2 14.5 1.0
O A:HOH934 2.3 19.2 1.0
SG A:CYS334 2.4 13.5 1.0
CE1 A:HIS511 3.0 14.7 1.0
CE1 A:HIS385 3.0 15.6 1.0
CB A:CYS334 3.1 13.7 1.0
CD2 A:HIS385 3.1 16.7 1.0
O A:HOH893 3.2 16.8 1.0
CG A:HIS511 3.4 15.1 1.0
CB A:HIS511 3.9 15.0 1.0
OD2 A:ASP383 4.0 19.1 1.0
CA A:CYS334 4.0 13.2 1.0
OD1 A:ASP383 4.1 19.6 1.0
C9 A:2CR702 4.1 17.1 1.0
N A:CYS334 4.1 12.8 1.0
ND1 A:HIS385 4.2 15.8 1.0
NE2 A:HIS511 4.2 15.3 1.0
O A:HOH888 4.2 14.2 1.0
CG A:HIS385 4.2 16.4 1.0
CD2 A:HIS511 4.4 15.5 1.0
CG A:ASP383 4.5 19.3 1.0
CA A:HIS511 4.7 15.1 1.0
C8 A:2CR702 4.8 17.5 1.0
C5 A:2CR702 4.9 16.9 1.0
C7 A:2CR702 5.0 17.5 1.0

Zinc binding site 2 out of 2 in 4p3p

Go back to Zinc Binding Sites List in 4p3p
Zinc binding site 2 out of 2 in the Structural Basis For Full-Spectrum Inhibition of Threonyl-Trna Synthetase By Borrelidin 3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structural Basis For Full-Spectrum Inhibition of Threonyl-Trna Synthetase By Borrelidin 3 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn701

b:21.4
occ:1.00
ND1 B:HIS511 2.1 12.3 1.0
NE2 B:HIS385 2.1 15.1 1.0
SG B:CYS334 2.2 13.6 1.0
O B:HOH920 2.3 28.4 1.0
CE1 B:HIS511 2.7 12.5 1.0
CB B:CYS334 2.8 13.7 1.0
CD2 B:HIS385 3.1 15.3 1.0
CE1 B:HIS385 3.2 14.7 1.0
O B:HOH900 3.3 29.1 1.0
CG B:HIS511 3.3 12.8 1.0
CA B:CYS334 3.8 13.2 1.0
CB B:HIS511 3.9 12.7 1.0
NE2 B:HIS511 3.9 13.0 1.0
OD2 B:ASP383 4.0 19.8 1.0
N B:CYS334 4.1 12.9 1.0
O B:HOH865 4.1 21.8 1.0
C9 B:2CR702 4.1 16.7 1.0
OD1 B:ASP383 4.1 20.1 1.0
CG B:HIS385 4.2 15.0 1.0
CD2 B:HIS511 4.2 13.1 1.0
ND1 B:HIS385 4.3 14.5 1.0
CG B:ASP383 4.5 19.9 1.0
CA B:HIS511 4.7 12.7 1.0
C8 B:2CR702 4.8 17.1 1.0
C7 B:2CR702 4.9 17.1 1.0
C10 B:2CR702 5.0 17.0 1.0

Reference:

P.Fang, X.Yu, S.Jeong, A.Mirando, K.Chen, X.Chen, S.Kim, C.S.Francklyn, M.Guo. Structural Basis For Full-Spectrum Inhibition of Translational and Nontranslational Functions on A Human Trna Synthetase To Be Published.
Page generated: Sun Oct 27 04:12:37 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy