Zinc in PDB 4p16: Crystal Structure of the Papain-Like Protease of Middle-East Respiratory Syndrome Coronavirus

The structure of Crystal Structure of the Papain-Like Protease of Middle-East Respiratory Syndrome Coronavirus, PDB code: 4p16 was solved by J.Lei, J.R.Mesters, Q.Ma, R.Hilgenfeld, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.60 / 2.50
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	100.891, 47.666, 88.425, 90.00, 122.35, 90.00
R / Rfree (%)	18.7 / 23.4

The binding sites of Zinc atom in the Crystal Structure of the Papain-Like Protease of Middle-East Respiratory Syndrome Coronavirus (pdb code 4p16). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Papain-Like Protease of Middle-East Respiratory Syndrome Coronavirus, PDB code: 4p16:

Zinc binding site 1 out of 1 in the Crystal Structure of the Papain-Like Protease of Middle-East Respiratory Syndrome Coronavirus


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Papain-Like Protease of Middle-East Respiratory Syndrome Coronavirus within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:62.5 occ:1.00 SG A:CYS191 2.2 58.6 1.0 SG A:CYS194 2.3 66.6 1.0 SG A:CYS228 2.3 61.0 1.0 SG A:CYS226 2.4 60.8 1.0 CB A:CYS228 3.1 57.3 1.0 CB A:CYS191 3.2 55.5 1.0 CB A:CYS226 3.3 57.1 1.0 CB A:CYS194 3.4 62.5 1.0 N A:CYS194 3.8 61.9 1.0 N A:CYS228 4.0 59.5 1.0 CA A:CYS228 4.2 57.7 1.0 CA A:CYS194 4.2 62.3 1.0 CB A:VAL193 4.5 62.5 1.0 CA A:CYS191 4.6 55.9 1.0 CA A:CYS226 4.6 57.1 1.0 NH2 A:ARG232 4.7 53.8 1.0 C A:VAL193 4.8 65.2 1.0 N A:GLN227 4.8 60.9 1.0 C A:CYS226 4.9 64.0 1.0 O A:GLU231 5.0 63.4 1.0

J.Lei, J.R.Mesters, C.Drosten, S.Anemuller, Q.Ma, R.Hilgenfeld. Crystal Structure of the Papain-Like Protease of Mers Coronavirus Reveals Unusual, Potentially Druggable Active-Site Features. Antiviral Res. V.109C 72 2014.
ISSN: ISSN 0166-3542
PubMed: 24992731
DOI: 10.1016/J.ANTIVIRAL.2014.06.011