Zinc in PDB 4ov4: Isopropylmalate Synthase Binding with Ketoisovalerate

All present enzymatic activity of Isopropylmalate Synthase Binding with Ketoisovalerate:
2.3.3.13;

The structure of Isopropylmalate Synthase Binding with Ketoisovalerate, PDB code: 4ov4 was solved by Z.Zhang, J.Wu, C.Wang, P.Zhang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.00
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	129.937, 129.937, 46.693, 90.00, 90.00, 120.00
R / Rfree (%)	15.9 / 20.9

The binding sites of Zinc atom in the Isopropylmalate Synthase Binding with Ketoisovalerate (pdb code 4ov4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Isopropylmalate Synthase Binding with Ketoisovalerate, PDB code: 4ov4:

Zinc binding site 1 out of 1 in the Isopropylmalate Synthase Binding with Ketoisovalerate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Isopropylmalate Synthase Binding with Ketoisovalerate within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:40.9 occ:1.00 NE2 A:HIS209 2.2 28.2 1.0 OD2 A:ASP15 2.2 32.2 1.0 NE2 A:HIS207 2.2 28.8 1.0 O A:HOH616 2.3 33.4 1.0 O2 A:KIV402 2.3 37.4 1.0 O3 A:KIV402 2.3 35.9 1.0 CE1 A:HIS209 3.0 29.5 1.0 C2 A:KIV402 3.0 38.7 1.0 CD2 A:HIS207 3.1 27.8 1.0 C1 A:KIV402 3.1 36.8 1.0 CG A:ASP15 3.3 35.8 1.0 CE1 A:HIS207 3.3 26.8 1.0 CD2 A:HIS209 3.3 26.7 1.0 OD1 A:ASP15 3.7 41.9 1.0 ND2 A:ASN243 3.9 27.6 1.0 O A:HOH575 4.1 44.2 1.0 O A:HOH561 4.1 35.5 1.0 NH2 A:ARG14 4.2 35.0 1.0 ND1 A:HIS209 4.2 28.3 1.0 O1 A:KIV402 4.2 38.5 1.0 CG A:HIS207 4.3 25.7 1.0 C3 A:KIV402 4.3 35.5 1.0 ND1 A:HIS207 4.3 25.7 1.0 CG A:HIS209 4.4 25.4 1.0 C5 A:KIV402 4.5 34.4 1.0 NH1 A:ARG14 4.5 37.5 1.0 CB A:ASP15 4.5 32.5 1.0 CG A:ASN243 4.8 26.1 1.0 CZ A:ARG14 4.8 34.3 1.0 OD1 A:ASN243 4.9 27.2 1.0

Z.Zhang, J.Wu, W.Lin, J.Wang, H.Yan, W.Zhao, J.Ma, J.Ding, P.Zhang, G.Zhao. Subdomain II of Alpha-Isopropylmalate Synthase Is Essential For Activity: Inferring A Mechanism of Feedback Inhibition To Be Published.