|
Atomistry » Zinc » PDB 4ojp-4owf » 4opx | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 4ojp-4owf » 4opx » |
Zinc in PDB 4opx: Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- CarboxamideEnzymatic activity of Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide
All present enzymatic activity of Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide:
2.4.2.30; Protein crystallography data
The structure of Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide, PDB code: 4opx
was solved by
J.M.Pascal,
J.D.Steffen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4opx:
The structure of Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide
(pdb code 4opx). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide, PDB code: 4opx: Jump to Zinc binding site number: 1; 2; 3; 4; Zinc binding site 1 out of 4 in 4opxGo back to Zinc Binding Sites List in 4opx
Zinc binding site 1 out
of 4 in the Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide
Mono view Stereo pair view
Zinc binding site 2 out of 4 in 4opxGo back to Zinc Binding Sites List in 4opx
Zinc binding site 2 out
of 4 in the Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide
Mono view Stereo pair view
Zinc binding site 3 out of 4 in 4opxGo back to Zinc Binding Sites List in 4opx
Zinc binding site 3 out
of 4 in the Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide
Mono view Stereo pair view
Zinc binding site 4 out of 4 in 4opxGo back to Zinc Binding Sites List in 4opx
Zinc binding site 4 out
of 4 in the Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide
Mono view Stereo pair view
Reference:
M.R.Patel,
A.Bhatt,
J.D.Steffen,
A.Chergui,
J.Murai,
Y.Pommier,
J.M.Pascal,
L.D.Trombetta,
F.R.Fronczek,
T.T.Talele.
Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-Carboxamide and 2,3-Dihydrobenzofuran-3(2H)-One-7-Carboxamide Derivatives As Poly(Adp-Ribose)Polymerase-1 Inhibitors. J.Med.Chem. V. 57 5579 2014.
Page generated: Sun Oct 27 03:55:57 2024
ISSN: ISSN 0022-2623 PubMed: 24922587 DOI: 10.1021/JM5002502 |
Last articlesZn in 9JYWZn in 9IR4 Zn in 9IR3 Zn in 9GMX Zn in 9GMW Zn in 9JEJ Zn in 9ERF Zn in 9ERE Zn in 9EGV Zn in 9EGW |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |