Atomistry » Zinc » PDB 4lmg-4m2v » 4m2v
Atomistry »
  Zinc »
    PDB 4lmg-4m2v »
      4m2v »

Zinc in PDB 4m2v: Genetically Engineered Carbonic Anhydrase IX in Complex with Brinzolamide

Enzymatic activity of Genetically Engineered Carbonic Anhydrase IX in Complex with Brinzolamide

All present enzymatic activity of Genetically Engineered Carbonic Anhydrase IX in Complex with Brinzolamide:
4.2.1.1;

Protein crystallography data

The structure of Genetically Engineered Carbonic Anhydrase IX in Complex with Brinzolamide, PDB code: 4m2v was solved by M.P.Pinard, C.D.Boone, B.D.Rife, C.T.Supuran, R.Mckenna, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 18.95 / 1.72
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.583, 41.788, 72.763, 90.00, 103.99, 90.00
R / Rfree (%) 13.2 / 16

Zinc Binding Sites:

The binding sites of Zinc atom in the Genetically Engineered Carbonic Anhydrase IX in Complex with Brinzolamide (pdb code 4m2v). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Genetically Engineered Carbonic Anhydrase IX in Complex with Brinzolamide, PDB code: 4m2v:

Zinc binding site 1 out of 1 in 4m2v

Go back to Zinc Binding Sites List in 4m2v
Zinc binding site 1 out of 1 in the Genetically Engineered Carbonic Anhydrase IX in Complex with Brinzolamide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Genetically Engineered Carbonic Anhydrase IX in Complex with Brinzolamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:7.0
occ:1.00
ND1 A:HIS119 2.0 5.2 1.0
N2 A:BZ1302 2.0 5.7 1.0
NE2 A:HIS94 2.0 5.9 1.0
NE2 A:HIS96 2.0 5.1 1.0
CE1 A:HIS119 2.9 4.6 1.0
HE1 A:HIS119 3.0 5.5 1.0
CD2 A:HIS94 3.0 6.9 1.0
CD2 A:HIS96 3.0 5.9 1.0
CE1 A:HIS94 3.0 7.3 1.0
S1 A:BZ1302 3.0 8.8 1.0
CE1 A:HIS96 3.1 8.0 1.0
O4 A:BZ1302 3.1 9.7 1.0
CG A:HIS119 3.1 3.5 1.0
HD2 A:HIS94 3.1 8.2 1.0
HD2 A:HIS96 3.2 7.1 1.0
HB2 A:HIS119 3.2 6.2 1.0
HE1 A:HIS94 3.3 8.8 1.0
HE1 A:HIS96 3.3 9.6 1.0
CB A:HIS119 3.6 5.1 1.0
HG1 A:THR199 3.6 9.5 1.0
HB3 A:HIS119 3.8 6.2 1.0
OG1 A:THR199 3.9 7.9 1.0
OE1 A:GLU106 4.0 5.6 1.0
NE2 A:HIS119 4.0 5.7 1.0
C7 A:BZ1302 4.1 10.2 1.0
ND1 A:HIS94 4.1 6.5 1.0
CG A:HIS94 4.1 5.2 1.0
ND1 A:HIS96 4.2 6.3 1.0
CG A:HIS96 4.2 4.5 1.0
O3 A:BZ1302 4.2 7.7 1.0
CD2 A:HIS119 4.2 6.4 1.0
HH2 A:TRP209 4.3 10.2 1.0
C8 A:BZ1302 4.7 12.2 1.0
HG23 A:THR200 4.8 13.7 1.0
HE2 A:HIS119 4.8 6.9 1.0
HD1 A:HIS94 4.9 7.8 1.0
HD1 A:HIS96 4.9 7.5 1.0
CD A:GLU106 5.0 7.3 1.0
HG11 A:VAL143 5.0 9.2 1.0

Reference:

M.A.Pinard, C.D.Boone, B.D.Rife, C.T.Supuran, R.Mckenna. Structural Study of Interaction Between Brinzolamide and Dorzolamide Inhibition of Human Carbonic Anhydrases. Bioorg.Med.Chem. V. 21 7210 2013.
ISSN: ISSN 0968-0896
PubMed: 24090602
DOI: 10.1016/J.BMC.2013.08.033
Page generated: Sun Oct 27 02:14:22 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy