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Zinc in PDB 4lqy: Crystal Structure of Human ENPP4 with Amp

Enzymatic activity of Crystal Structure of Human ENPP4 with Amp

All present enzymatic activity of Crystal Structure of Human ENPP4 with Amp:
3.6.1.29;

Protein crystallography data

The structure of Crystal Structure of Human ENPP4 with Amp, PDB code: 4lqy was solved by R.A.Albright, D.T.Braddock, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.85 / 1.54
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 181.533, 51.143, 52.741, 90.00, 102.38, 90.00
R / Rfree (%) 14 / 18.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Human ENPP4 with Amp (pdb code 4lqy). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human ENPP4 with Amp, PDB code: 4lqy:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4lqy

Go back to Zinc Binding Sites List in 4lqy
Zinc binding site 1 out of 2 in the Crystal Structure of Human ENPP4 with Amp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human ENPP4 with Amp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn506

b:16.4
occ:1.00
NE2 A:HIS238 2.0 11.1 1.0
OD2 A:ASP237 2.0 11.8 1.0
OD1 A:ASP34 2.0 15.1 1.0
OG1 A:THR70 2.0 11.4 1.0
CG A:ASP34 2.6 9.8 1.0
OD2 A:ASP34 2.6 19.8 1.0
CG A:ASP237 2.8 19.2 1.0
CD2 A:HIS238 2.9 18.4 1.0
CE1 A:HIS238 2.9 11.6 1.0
CB A:THR70 3.0 13.8 1.0
OD1 A:ASP237 3.1 14.1 1.0
CA A:THR70 3.4 13.8 1.0
CG2 A:THR70 3.4 14.6 1.0
O2P A:AMP505 3.9 27.4 1.0
N A:THR70 4.0 10.1 1.0
CG A:HIS238 4.0 13.6 1.0
ND1 A:HIS238 4.0 10.7 1.0
OD1 A:ASP189 4.0 18.1 1.0
O3' A:AMP505 4.0 38.2 1.0
CB A:ASP34 4.0 13.4 1.0
N A:GLY35 4.2 12.4 1.0
CB A:ASP237 4.2 14.3 1.0
CE1 A:HIS336 4.3 12.2 1.0
O3P A:AMP505 4.3 17.9 1.0
CG A:ASP189 4.3 11.8 1.0
CE1 A:HIS74 4.4 12.7 1.0
CA A:ASP34 4.5 14.1 1.0
ZN A:ZN507 4.6 15.4 1.0
NE2 A:HIS336 4.6 13.0 1.0
C A:THR70 4.7 14.5 1.0
C A:ASP34 4.7 12.8 1.0
CB A:ASP189 4.7 16.3 1.0
C A:LYS69 4.7 13.9 1.0
P A:AMP505 4.8 22.2 1.0
CA A:GLY35 4.8 15.3 1.0
C3' A:AMP505 4.8 48.2 1.0
ND1 A:HIS74 4.9 12.9 1.0
OD2 A:ASP189 4.9 19.0 1.0

Zinc binding site 2 out of 2 in 4lqy

Go back to Zinc Binding Sites List in 4lqy
Zinc binding site 2 out of 2 in the Crystal Structure of Human ENPP4 with Amp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human ENPP4 with Amp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn507

b:15.4
occ:1.00
O2P A:AMP505 2.0 27.4 1.0
NE2 A:HIS193 2.0 11.9 1.0
NE2 A:HIS336 2.1 13.0 1.0
OD1 A:ASP189 2.1 18.1 1.0
O A:HOH874 2.3 35.4 1.0
OD2 A:ASP189 2.6 19.0 1.0
CG A:ASP189 2.7 11.8 1.0
P A:AMP505 2.8 22.2 1.0
CD2 A:HIS193 2.9 16.5 1.0
O1P A:AMP505 3.0 31.9 1.0
CE1 A:HIS193 3.0 14.8 1.0
CE1 A:HIS336 3.0 12.2 1.0
CD2 A:HIS336 3.1 13.4 1.0
O3P A:AMP505 3.8 17.9 1.0
CE1 A:HIS238 4.0 11.6 1.0
O5' A:AMP505 4.1 29.6 1.0
O3' A:AMP505 4.1 38.2 1.0
O A:HOH753 4.1 31.3 1.0
CG A:HIS193 4.1 12.7 1.0
ND1 A:HIS193 4.1 12.3 1.0
CB A:ASP189 4.2 16.3 1.0
ND1 A:HIS336 4.2 10.4 1.0
CG A:HIS336 4.2 8.7 1.0
NE2 A:HIS238 4.3 11.1 1.0
OG1 A:THR70 4.3 11.4 1.0
CE A:MET240 4.4 13.3 1.0
ZN A:ZN506 4.6 16.4 1.0
OD1 A:ASP34 4.6 15.1 1.0
O A:HOH788 4.7 28.1 1.0
O A:ASP189 4.8 14.2 1.0
C5' A:AMP505 4.9 37.4 1.0
CA A:ASP189 5.0 13.6 1.0

Reference:

R.A.Albright, D.L.Ornstein, W.Cao, W.C.Chang, D.Robert, M.Tehan, D.Hoyer, L.Liu, P.Stabach, G.Yang, E.M.De La Cruz, D.T.Braddock. Molecular Basis of Purinergic Signal Metabolism By Ectonucleotide Pyrophosphatase/Phosphodiesterases 4 and 1 and Implications in Stroke. J.Biol.Chem. V. 289 3294 2014.
ISSN: ISSN 0021-9258
PubMed: 24338010
DOI: 10.1074/JBC.M113.505867
Page generated: Wed Dec 16 05:33:42 2020

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