Zinc in PDB 4jlz: Structure of Porcine Cgas in Complex with Bound Utp

The structure of Structure of Porcine Cgas in Complex with Bound Utp, PDB code: 4jlz was solved by F.Civril, K.P.Hopfner, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.56 / 2.27
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	80.560, 97.693, 106.959, 90.00, 90.00, 90.00
R / Rfree (%)	17.2 / 20.7

The structure of Structure of Porcine Cgas in Complex with Bound Utp also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Zinc atom in the Structure of Porcine Cgas in Complex with Bound Utp (pdb code 4jlz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Porcine Cgas in Complex with Bound Utp, PDB code: 4jlz:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Porcine Cgas in Complex with Bound Utp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Porcine Cgas in Complex with Bound Utp within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:16.8 occ:1.00 NE2 A:HIS367 2.1 30.3 1.0 SG A:CYS373 2.3 18.7 1.0 SG A:CYS374 2.3 16.4 1.0 SG A:CYS381 2.3 13.9 1.0 CD2 A:HIS367 2.9 12.8 1.0 CE1 A:HIS367 3.3 24.4 1.0 CB A:CYS381 3.3 14.6 1.0 CB A:CYS374 3.3 17.6 1.0 CB A:CYS373 3.6 15.3 1.0 C A:CYS373 3.7 19.0 1.0 N A:CYS374 3.7 18.2 1.0 N A:CYS381 3.8 16.6 1.0 O A:HOH608 3.9 25.6 1.0 CA A:CYS381 4.0 15.8 1.0 O A:CYS373 4.0 17.0 1.0 CG A:HIS367 4.1 15.7 1.0 CA A:CYS374 4.1 18.8 1.0 CA A:CYS373 4.2 24.0 1.0 ND1 A:HIS367 4.2 22.0 1.0 NH1 A:ARG383 4.3 13.3 1.0 C A:CYS381 4.4 16.4 1.0 O A:CYS381 4.4 17.1 1.0 O A:HOH642 4.5 20.1 1.0 O A:HOH748 4.7 35.5 1.0 O A:VAL379 4.8 17.5 1.0 C A:LYS380 4.9 24.0 1.0

Zinc binding site 2 out of 2 in the Structure of Porcine Cgas in Complex with Bound Utp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Porcine Cgas in Complex with Bound Utp within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn501 b:20.0 occ:1.00 NE2 B:HIS367 2.1 22.4 1.0 SG B:CYS374 2.3 15.3 1.0 SG B:CYS381 2.4 14.7 1.0 SG B:CYS373 2.5 20.3 1.0 CD2 B:HIS367 2.9 17.2 1.0 CE1 B:HIS367 3.2 23.4 1.0 CB B:CYS381 3.3 16.0 1.0 CB B:CYS374 3.3 14.5 1.0 N B:CYS381 3.7 16.6 1.0 CB B:CYS373 3.7 19.1 1.0 N B:CYS374 3.7 15.5 1.0 O B:HOH626 3.8 23.9 1.0 C B:CYS373 3.8 15.0 1.0 CA B:CYS381 4.0 16.6 1.0 CA B:CYS374 4.1 17.7 1.0 O B:CYS373 4.1 14.4 1.0 CG B:HIS367 4.2 17.6 1.0 CA B:CYS373 4.3 18.9 1.0 ND1 B:HIS367 4.3 21.8 1.0 NH1 B:ARG383 4.3 18.6 1.0 O B:HOH694 4.4 37.1 1.0 C B:CYS381 4.5 16.6 1.0 O B:HOH606 4.5 16.6 1.0 O B:CYS381 4.6 15.9 1.0 C B:LYS380 4.8 28.8 1.0 O B:VAL379 4.9 17.5 1.0

F.Civril, T.Deimling, C.C.O.Mann, A.Ablasser, M.Moldt, G.Witte, V.Hornung, K.P.Hopfner. Structural Mechanism of Cytosolic Dna Sensing By Cgas Nature V. 498 332 2013.
ISSN: ISSN 0028-0836
PubMed: 23722159
DOI: 10.1038/NATURE12305