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Zinc in PDB 4hi9: 1.2 Structure of Integrin-Linked Kinase Ankyrin Repeat Domain in Complex with PINCH1 LIM1 Domain Collected at Wavelength 0.91974

Enzymatic activity of 1.2 Structure of Integrin-Linked Kinase Ankyrin Repeat Domain in Complex with PINCH1 LIM1 Domain Collected at Wavelength 0.91974

All present enzymatic activity of 1.2 Structure of Integrin-Linked Kinase Ankyrin Repeat Domain in Complex with PINCH1 LIM1 Domain Collected at Wavelength 0.91974:
2.7.11.1;

Protein crystallography data

The structure of 1.2 Structure of Integrin-Linked Kinase Ankyrin Repeat Domain in Complex with PINCH1 LIM1 Domain Collected at Wavelength 0.91974, PDB code: 4hi9 was solved by A.L.Stiegler, J.Jakoncic, V.Stojanoff, B.P.Chiswell, D.A.Calderwood, T.J.Boggon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 34.66 / 1.20
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 37.144, 41.775, 46.798, 78.67, 68.94, 85.81
R / Rfree (%) 17.5 / 19.8

Other elements in 4hi9:

The structure of 1.2 Structure of Integrin-Linked Kinase Ankyrin Repeat Domain in Complex with PINCH1 LIM1 Domain Collected at Wavelength 0.91974 also contains other interesting chemical elements:

Iodine (I) 10 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the 1.2 Structure of Integrin-Linked Kinase Ankyrin Repeat Domain in Complex with PINCH1 LIM1 Domain Collected at Wavelength 0.91974 (pdb code 4hi9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the 1.2 Structure of Integrin-Linked Kinase Ankyrin Repeat Domain in Complex with PINCH1 LIM1 Domain Collected at Wavelength 0.91974, PDB code: 4hi9:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4hi9

Go back to Zinc Binding Sites List in 4hi9
Zinc binding site 1 out of 2 in the 1.2 Structure of Integrin-Linked Kinase Ankyrin Repeat Domain in Complex with PINCH1 LIM1 Domain Collected at Wavelength 0.91974


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of 1.2 Structure of Integrin-Linked Kinase Ankyrin Repeat Domain in Complex with PINCH1 LIM1 Domain Collected at Wavelength 0.91974 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn101

b:25.8
occ:1.00
 ND1 B:HIS32 2.1 27.7 1.0
SG B:CYS35 2.3 25.6 1.0
SG B:CYS13 2.3 29.3 1.0
SG B:CYS10 2.3 23.9 1.0
CE1 B:HIS32 3.0 29.6 1.0
HB2 B:HIS32 3.0 30.1 1.0
HB3 B:CYS10 3.0 30.7 1.0
HB3 B:CYS13 3.0 36.9 1.0
CB B:CYS10 3.1 25.6 1.0
HE1 B:HIS32 3.1 35.5 1.0
HB2 B:CYS10 3.1 30.7 1.0
CG B:HIS32 3.2 25.7 1.0
HB2 B:CYS35 3.2 27.9 1.0
H B:CYS13 3.2 35.4 1.0
H B:HIS32 3.3 27.6 1.0
CB B:CYS35 3.3 23.2 1.0
CB B:CYS13 3.3 30.7 1.0
HB3 B:CYS35 3.4 27.9 1.0
CB B:HIS32 3.6 25.0 1.0
N B:CYS13 3.9 29.5 1.0
HB3 B:ARG12 3.9 27.8 1.0
HB2 B:CYS13 4.0 36.9 1.0
N B:HIS32 4.0 23.0 1.0
CA B:CYS13 4.1 31.9 1.0
NE2 B:HIS32 4.2 29.1 1.0
CD2 B:HIS32 4.3 28.2 1.0
HE B:ARG12 4.3 26.6 1.0
HB3 B:HIS32 4.3 30.1 1.0
H B:GLY15 4.3 45.2 1.0
CA B:HIS32 4.4 25.4 1.0
H B:LYS14 4.6 42.6 1.0
CA B:CYS10 4.6 27.1 1.0
H B:ARG12 4.6 30.9 1.0
HH21 B:ARG12 4.6 26.8 1.0
HA B:TYR31 4.6 26.1 1.0
CA B:CYS35 4.7 23.8 1.0
C B:CYS13 4.8 33.5 1.0
CB B:ARG12 4.8 23.2 1.0
NE B:ARG12 4.9 22.2 1.0
N B:LYS14 4.9 35.5 1.0
HE2 B:HIS32 4.9 34.9 1.0
HA B:CYS35 4.9 28.5 1.0
HA B:CYS10 4.9 32.5 1.0
HA B:CYS13 5.0 38.3 1.0
H B:CYS35 5.0 29.1 1.0

Zinc binding site 2 out of 2 in 4hi9

Go back to Zinc Binding Sites List in 4hi9
Zinc binding site 2 out of 2 in the 1.2 Structure of Integrin-Linked Kinase Ankyrin Repeat Domain in Complex with PINCH1 LIM1 Domain Collected at Wavelength 0.91974


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of 1.2 Structure of Integrin-Linked Kinase Ankyrin Repeat Domain in Complex with PINCH1 LIM1 Domain Collected at Wavelength 0.91974 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn102

b:18.1
occ:1.00
 OD2 B:ASP62 1.9 17.9 1.0
SG B:CYS41 2.3 17.8 1.0
SG B:CYS38 2.3 17.5 1.0
SG B:CYS59 2.4 21.0 1.0
HB3 B:CYS38 2.9 22.4 1.0
CG B:ASP62 3.0 17.7 1.0
HB2 B:ASP62 3.0 20.8 1.0
H B:CYS41 3.0 19.2 1.0
HB3 B:CYS41 3.1 21.1 1.0
CB B:CYS38 3.1 18.7 1.0
HB2 B:CYS38 3.2 22.4 1.0
H B:CYS59 3.3 21.7 1.0
CB B:CYS41 3.3 17.6 1.0
HB3 B:CYS59 3.4 23.7 1.0
CB B:ASP62 3.5 17.4 1.0
HB3 B:GLN40 3.5 21.2 1.0
CB B:CYS59 3.6 19.8 1.0
N B:CYS41 3.7 16.0 1.0
H B:ASP62 3.8 21.3 1.0
N B:CYS59 4.0 18.1 1.0
CA B:CYS41 4.1 16.9 1.0
HB2 B:CYS41 4.1 21.1 1.0
OD1 B:ASP62 4.1 18.2 1.0
HB3 B:ASP62 4.1 20.8 1.0
H B:GLN40 4.2 19.2 1.0
HB2 B:CYS59 4.3 23.7 1.0
CA B:CYS59 4.4 19.4 1.0
O B:HOH228 4.4 26.8 1.0
HE2 A:HIS99 4.5 20.5 1.0
CB B:GLN40 4.5 17.7 1.0
N B:ASP62 4.5 17.7 1.0
CA B:CYS38 4.5 17.6 1.0
O B:HOH227 4.5 31.4 1.0
C B:GLN40 4.6 16.0 1.0
CA B:ASP62 4.7 16.6 1.0
HB3 B:HIS61 4.7 23.0 1.0
H B:GLN43 4.7 21.2 1.0
HA B:TYR58 4.8 21.2 1.0
NE2 A:HIS99 4.8 17.1 1.0
H B:PHE42 4.8 20.5 1.0
HA B:CYS41 4.8 20.2 1.0
HE1 A:HIS99 4.8 21.0 1.0
HD2 B:HIS61 4.8 24.9 1.0
N B:GLN40 4.9 16.0 1.0
CA B:GLN40 4.9 16.8 1.0
CE1 A:HIS99 4.9 17.5 1.0
HA B:CYS38 5.0 21.1 1.0
HB2 B:GLN43 5.0 24.7 1.0
HB3 B:TYR58 5.0 22.0 1.0
HB2 B:GLN40 5.0 21.2 1.0
HD1 B:TYR58 5.0 22.8 1.0
C B:CYS41 5.0 17.1 1.0
C B:CYS38 5.0 17.3 1.0

Reference:

A.L.Stiegler, J.Jakoncic, V.Stojanoff, B.P.Chiswell, D.A.Calderwood, T.J.Boggon. 1.2 Structure of Integrin-Linked Kinase Ankyrin Repeat Domain in Complex with PINCH1 LIM1 Domain Collected at Wavelength 0.91974 To Be Published.
Page generated: Wed Dec 16 05:22:15 2020

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