Zinc in PDB 4guq: Structure of MUTS139F P73 Dna Binding Domain Complexed with 20BP Dna Response Element

The structure of Structure of MUTS139F P73 Dna Binding Domain Complexed with 20BP Dna Response Element, PDB code: 4guq was solved by A.S.Ethayathulla, H.T.Nguyen, H.Viadiu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	100.00 / 3.70
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	172.498, 172.498, 34.093, 90.00, 90.00, 120.00
R / Rfree (%)	30.2 / 31.6

The binding sites of Zinc atom in the Structure of MUTS139F P73 Dna Binding Domain Complexed with 20BP Dna Response Element (pdb code 4guq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of MUTS139F P73 Dna Binding Domain Complexed with 20BP Dna Response Element, PDB code: 4guq:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of MUTS139F P73 Dna Binding Domain Complexed with 20BP Dna Response Element


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of MUTS139F P73 Dna Binding Domain Complexed with 20BP Dna Response Element within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:88.1 occ:1.00 ND1 A:HIS197 2.0 80.7 1.0 SG A:CYS194 2.3 84.6 1.0 SG A:CYS262 2.3 75.9 1.0 SG A:CYS258 2.3 85.6 1.0 CE1 A:HIS197 2.9 83.3 1.0 CB A:CYS262 2.9 77.3 1.0 CB A:CYS194 3.0 80.5 1.0 CG A:HIS197 3.1 83.3 1.0 CB A:CYS258 3.4 76.4 1.0 CB A:HIS197 3.5 82.1 1.0 CA A:CYS258 3.5 72.2 1.0 N A:CYS194 3.9 71.1 1.0 O A:MET257 4.0 70.8 1.0 CA A:CYS194 4.1 78.0 1.0 NE2 A:HIS197 4.1 84.6 1.0 N A:ASN259 4.2 66.2 1.0 CD2 A:HIS197 4.2 85.5 1.0 CA A:CYS262 4.3 81.3 1.0 O A:CYS194 4.3 83.6 1.0 C A:CYS258 4.4 69.2 1.0 N A:HIS197 4.6 86.0 1.0 N A:CYS258 4.6 70.6 1.0 C A:CYS194 4.7 83.4 1.0 CA A:HIS197 4.7 83.8 1.0 C A:MET257 4.8 69.2 1.0 C A:CYS262 4.9 88.1 1.0

Zinc binding site 2 out of 2 in the Structure of MUTS139F P73 Dna Binding Domain Complexed with 20BP Dna Response Element


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of MUTS139F P73 Dna Binding Domain Complexed with 20BP Dna Response Element within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn401 b:83.9 occ:1.00 ND1 B:HIS197 2.0 78.3 1.0 SG B:CYS258 2.3 71.8 1.0 SG B:CYS194 2.3 0.3 1.0 SG B:CYS262 2.3 73.4 1.0 CG B:HIS197 2.8 80.5 1.0 CB B:HIS197 3.0 82.2 1.0 CE1 B:HIS197 3.1 81.3 1.0 CB B:CYS258 3.5 66.8 1.0 CA B:CYS258 3.6 64.2 1.0 CB B:CYS262 3.6 77.4 1.0 CB B:CYS194 3.8 96.4 1.0 O B:MET257 3.9 63.0 1.0 CD2 B:HIS197 4.1 80.6 1.0 NE2 B:HIS197 4.2 82.7 1.0 N B:CYS194 4.2 86.4 1.0 O B:CYS194 4.3 80.8 1.0 N B:ASN259 4.3 65.2 1.0 CA B:HIS197 4.3 87.9 1.0 N B:HIS197 4.4 91.7 1.0 C B:CYS258 4.4 63.0 1.0 CA B:CYS194 4.5 89.8 1.0 N B:CYS258 4.6 61.5 1.0 C B:MET257 4.7 61.6 1.0 C B:CYS194 4.8 86.7 1.0 CA B:CYS262 4.9 81.1 1.0 CD B:ARG193 5.0 72.2 1.0

Y.Ciribilli, P.Monti, A.Bisio, H.T.Nguyen, A.S.Ethayathulla, A.Ramos, G.Foggetti, P.Menichini, D.Menendez, M.A.Resnick, H.Viadiu, G.Fronza, A.Inga. Transactivation Specificity Is Conserved Among P53 Family Proteins and Depends on A Response Element Sequence Code. Nucleic Acids Res. V. 41 8637 2013.
ISSN: ISSN 0305-1048
PubMed: 23892287
DOI: 10.1093/NAR/GKT657