Zinc in PDB 3uik: Crystal Structure of Human Survivin Mutant K62Y/H80W in Complex with H3(1-10) Peptide

The structure of Crystal Structure of Human Survivin Mutant K62Y/H80W in Complex with H3(1-10) Peptide, PDB code: 3uik was solved by J.Du, D.J.Patel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	27.68 / 2.70
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	115.503, 71.389, 81.874, 90.00, 128.73, 90.00
R / Rfree (%)	21.9 / 28.1

The binding sites of Zinc atom in the Crystal Structure of Human Survivin Mutant K62Y/H80W in Complex with H3(1-10) Peptide (pdb code 3uik). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Survivin Mutant K62Y/H80W in Complex with H3(1-10) Peptide, PDB code: 3uik:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human Survivin Mutant K62Y/H80W in Complex with H3(1-10) Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Survivin Mutant K62Y/H80W in Complex with H3(1-10) Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn341 b:94.0 occ:1.00 SG A:CYS60 2.2 93.2 1.0 SG A:CYS84 2.4 0.4 1.0 SG A:CYS57 2.4 80.0 1.0 NE2 A:HIS77 2.5 0.6 1.0 CE1 A:HIS77 2.7 0.0 1.0 CB A:CYS84 2.8 78.9 1.0 CB A:CYS60 3.0 62.2 1.0 CB A:CYS57 3.4 92.7 1.0 N A:CYS60 3.4 74.7 1.0 CD2 A:HIS77 3.8 0.4 1.0 CA A:CYS60 3.8 71.8 1.0 ND1 A:HIS77 4.1 0.1 1.0 CB A:PHE59 4.1 72.2 1.0 CA A:CYS84 4.3 97.2 1.0 C A:PHE59 4.5 77.6 1.0 CG A:HIS77 4.6 0.1 1.0 C A:CYS60 4.7 72.2 1.0 OG A:SER81 4.7 83.0 1.0 CA A:PHE59 4.7 66.3 1.0 CA A:CYS57 4.8 75.3 1.0 N A:PHE61 4.8 75.6 1.0 N A:PHE59 4.9 71.2 1.0 CD2 A:PHE59 4.9 0.4 1.0 CB A:PHE86 4.9 0.8 1.0 CG A:PHE59 5.0 92.2 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human Survivin Mutant K62Y/H80W in Complex with H3(1-10) Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Survivin Mutant K62Y/H80W in Complex with H3(1-10) Peptide within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn341 b:0.2 occ:1.00 SG B:CYS60 2.2 0.4 1.0 SG B:CYS57 2.3 99.3 1.0 NE2 B:HIS77 2.4 0.2 1.0 SG B:CYS84 2.4 0.5 1.0 CE1 B:HIS77 2.6 0.3 1.0 CB B:CYS57 3.1 93.9 1.0 CB B:CYS84 3.2 0.7 1.0 CB B:CYS60 3.4 0.4 1.0 CD2 B:HIS77 3.7 0.9 1.0 N B:CYS60 3.8 0.6 1.0 ND1 B:HIS77 4.0 0.2 1.0 CA B:CYS60 4.2 0.3 1.0 CG B:HIS77 4.5 0.2 1.0 CA B:CYS84 4.5 0.4 1.0 CB B:PHE59 4.5 96.0 1.0 CA B:CYS57 4.6 0.6 1.0 C B:PHE59 4.9 0.5 1.0 C B:CYS60 4.9 0.1 1.0

J.Du, A.E.Kelly, H.Funabiki, D.J.Patel. Structural Basis For Recognition of H3T3PH and Smac/Diablo N-Terminal Peptides By Human Survivin. Structure V. 20 185 2012.
ISSN: ISSN 0969-2126
PubMed: 22244766
DOI: 10.1016/J.STR.2011.12.001