Zinc in PDB 3qmi: Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Acgt) By the Cxxc Domain of CFP1

The structure of Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Acgt) By the Cxxc Domain of CFP1, PDB code: 3qmi was solved by C.Xu, C.Bian, F.Mackenzie, C.Bountra, J.Weigelt, C.H.Arrowsmith, A.M.Edwards, J.Min, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.50 / 2.10
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	30.624, 75.009, 125.905, 90.00, 90.00, 90.00
R / Rfree (%)	20.7 / 25.8

The binding sites of Zinc atom in the Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Acgt) By the Cxxc Domain of CFP1 (pdb code 3qmi). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Acgt) By the Cxxc Domain of CFP1, PDB code: 3qmi:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Acgt) By the Cxxc Domain of CFP1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Acgt) By the Cxxc Domain of CFP1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn300 b:13.8 occ:1.00 SG A:CYS208 2.3 12.1 1.0 SG A:CYS175 2.3 14.8 1.0 SG A:CYS172 2.4 13.6 1.0 SG A:CYS169 2.4 14.2 1.0 CB A:CYS208 3.3 11.4 1.0 CB A:CYS172 3.4 11.9 1.0 CB A:CYS175 3.4 14.2 1.0 N A:CYS169 3.4 10.2 1.0 CB A:CYS169 3.5 13.0 1.0 CA A:CYS208 3.7 10.7 1.0 N A:CYS172 3.7 12.9 1.0 N A:GLY170 3.8 13.4 1.0 CA A:CYS169 3.9 13.1 1.0 N A:GLN209 4.1 12.2 1.0 CA A:CYS172 4.1 13.3 1.0 N A:CYS175 4.1 14.4 1.0 C A:CYS169 4.2 12.6 1.0 C A:CYS208 4.3 12.2 1.0 CA A:CYS175 4.4 14.7 1.0 N A:GLU171 4.4 13.0 1.0 C A:MET168 4.5 13.8 1.0 N A:LEU210 4.7 15.7 1.0 CA A:GLY170 4.8 13.3 1.0 C A:CYS172 4.8 15.0 1.0 CA A:MET168 4.8 12.5 1.0 C A:GLU171 4.9 14.2 1.0 O A:CYS172 4.9 13.3 1.0 N A:CYS208 5.0 13.0 1.0

Zinc binding site 2 out of 2 in the Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Acgt) By the Cxxc Domain of CFP1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structural Basis of Selective Binding of Non-Methylated Cpg Islands (Dna-Acgt) By the Cxxc Domain of CFP1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:13.6 occ:1.00 SG A:CYS203 2.3 9.7 1.0 SG A:CYS181 2.3 12.2 1.0 SG A:CYS184 2.3 13.2 1.0 SG A:CYS187 2.4 12.2 1.0 CB A:CYS203 3.3 10.6 1.0 CB A:CYS187 3.4 11.0 1.0 CB A:CYS181 3.4 13.2 1.0 CB A:CYS184 3.5 13.9 1.0 N A:CYS181 3.5 15.2 1.0 CA A:CYS203 3.7 10.5 1.0 N A:GLY182 3.8 14.5 1.0 N A:CYS184 3.9 15.3 1.0 N A:ARG204 3.9 10.4 1.0 CA A:CYS181 3.9 14.4 1.0 C A:CYS203 4.2 10.3 1.0 C A:CYS181 4.2 15.3 1.0 N A:CYS187 4.2 11.9 1.0 CA A:CYS184 4.2 13.1 1.0 N A:HIS183 4.3 15.4 1.0 CA A:CYS187 4.4 11.0 1.0 C A:ASP180 4.6 14.6 1.0 N A:LEU205 4.8 10.8 1.0 CA A:GLY182 4.8 13.8 1.0 C A:CYS184 4.9 13.8 1.0 CA A:ARG204 4.9 12.3 1.0 O A:CYS184 4.9 15.0 1.0 CB A:ARG204 4.9 13.8 1.0 N A:CYS203 4.9 12.8 1.0 CA A:ASP180 5.0 15.8 1.0 C A:HIS183 5.0 18.8 1.0 C A:GLY182 5.0 14.5 1.0

C.Xu, C.Bian, R.Lam, A.Dong, J.Min. The Structural Basis For Selective Binding of Non-Methylated Cpg Islands By the CFP1 Cxxc Domain. Nat Commun V. 2 227 2011.
ISSN: ESSN 2041-1723
PubMed: 21407193
DOI: 10.1038/NCOMMS1237