Zinc in PDB 3q7j: Engineered Thermoplasma Acidophilum F3 Factor Mimics Human Aminopeptidase N (Apn) As A Target For Anticancer Drug Development

The structure of Engineered Thermoplasma Acidophilum F3 Factor Mimics Human Aminopeptidase N (Apn) As A Target For Anticancer Drug Development, PDB code: 3q7j was solved by J.Su, Q.Wang, J.Feng, C.Zhang, D.Zhu, T.We, W.Xu, L.Gu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.95 / 2.91
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	114.717, 183.101, 105.154, 90.00, 90.00, 90.00
R / Rfree (%)	20.2 / 27.1

The binding sites of Zinc atom in the Engineered Thermoplasma Acidophilum F3 Factor Mimics Human Aminopeptidase N (Apn) As A Target For Anticancer Drug Development (pdb code 3q7j). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Engineered Thermoplasma Acidophilum F3 Factor Mimics Human Aminopeptidase N (Apn) As A Target For Anticancer Drug Development, PDB code: 3q7j:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Engineered Thermoplasma Acidophilum F3 Factor Mimics Human Aminopeptidase N (Apn) As A Target For Anticancer Drug Development


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Engineered Thermoplasma Acidophilum F3 Factor Mimics Human Aminopeptidase N (Apn) As A Target For Anticancer Drug Development within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn800 b:46.7 occ:1.00 OE1 A:GLU288 2.0 45.9 1.0 NE2 A:HIS269 2.2 36.6 1.0 NE2 A:HIS265 2.5 38.1 1.0 CD A:GLU288 2.7 48.3 1.0 N12 A:FBO900 2.8 52.6 1.0 CD2 A:HIS269 2.9 35.3 1.0 OE2 A:GLU288 2.9 50.0 1.0 CD2 A:HIS265 3.2 37.0 1.0 CE1 A:HIS269 3.4 36.5 1.0 CE1 A:HIS265 3.6 37.4 1.0 OE2 A:GLU266 3.7 39.0 1.0 N10 A:FBO900 3.9 60.9 1.0 C8 A:FBO900 4.0 63.5 1.0 OE1 A:GLU266 4.1 48.5 1.0 CG A:GLU288 4.1 44.6 1.0 CG A:HIS269 4.2 33.3 1.0 OE1 A:GLU233 4.2 42.0 1.0 C9 A:FBO900 4.2 67.5 1.0 CD A:GLU266 4.3 43.4 1.0 CB A:ALA291 4.3 36.8 1.0 CG A:HIS265 4.3 36.7 1.0 ND1 A:HIS269 4.4 34.3 1.0 OE2 A:GLU233 4.4 41.4 1.0 CD A:GLU233 4.4 41.8 1.0 ND1 A:HIS265 4.5 34.7 1.0 CA A:GLU288 4.6 33.9 1.0 C15 A:FBO900 4.6 63.4 1.0 C14 A:FBO900 4.8 60.4 1.0 C7 A:FBO900 4.9 57.2 1.0 CB A:GLU288 5.0 35.2 1.0

Zinc binding site 2 out of 2 in the Engineered Thermoplasma Acidophilum F3 Factor Mimics Human Aminopeptidase N (Apn) As A Target For Anticancer Drug Development


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Engineered Thermoplasma Acidophilum F3 Factor Mimics Human Aminopeptidase N (Apn) As A Target For Anticancer Drug Development within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn800 b:47.2 occ:1.00 NE2 B:HIS269 2.2 34.6 1.0 OE2 B:GLU288 2.3 37.1 1.0 NE2 B:HIS265 2.7 31.3 1.0 CD2 B:HIS269 2.8 35.0 1.0 CD B:GLU288 3.1 45.3 1.0 CD2 B:HIS265 3.1 31.9 1.0 OE1 B:GLU288 3.2 45.1 1.0 CE1 B:HIS269 3.3 34.6 1.0 OE2 B:GLU233 3.4 31.5 1.0 OE1 B:GLU266 3.8 32.8 1.0 OE2 B:GLU266 4.0 36.9 1.0 CE1 B:HIS265 4.0 35.4 1.0 CG B:HIS269 4.0 35.2 1.0 CD B:GLU233 4.1 30.2 1.0 ND1 B:HIS269 4.2 31.5 1.0 CD B:GLU266 4.2 35.1 1.0 OE1 B:GLU233 4.4 29.9 1.0 CG B:HIS265 4.4 31.7 1.0 CB B:ALA291 4.5 38.9 1.0 CG B:GLU288 4.5 40.2 1.0 CA B:GLU288 4.7 34.5 1.0 ND1 B:HIS265 4.8 35.5 1.0

J.Su, Q.Wang, J.Feng, C.Zhang, D.Zhu, T.Wei, W.Xu, L.Gu. Engineered Thermoplasma Acidophilum Factor F3 Mimics Human Aminopeptidase N (Apn) As A Target For Anticancer Drug Development Bioorg.Med.Chem. V. 19 2991 2011.
ISSN: ISSN 0968-0896
PubMed: 21493078
DOI: 10.1016/J.BMC.2011.03.028