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Zinc in PDB 3mk5: Crystal Structure of 3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase Domain From Mycobacterium Tuberculosis with Sulfate and Zinc at pH 4.00

Enzymatic activity of Crystal Structure of 3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase Domain From Mycobacterium Tuberculosis with Sulfate and Zinc at pH 4.00

All present enzymatic activity of Crystal Structure of 3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase Domain From Mycobacterium Tuberculosis with Sulfate and Zinc at pH 4.00:
4.1.99.12;

Protein crystallography data

The structure of Crystal Structure of 3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase Domain From Mycobacterium Tuberculosis with Sulfate and Zinc at pH 4.00, PDB code: 3mk5 was solved by M.Singh, S.Karthikeyan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 34.69 / 2.06
Space group P 61
Cell size a, b, c (Å), α, β, γ (°) 65.442, 65.442, 87.740, 90.00, 90.00, 120.00
R / Rfree (%) 19.2 / 23.6

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of 3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase Domain From Mycobacterium Tuberculosis with Sulfate and Zinc at pH 4.00 (pdb code 3mk5). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of 3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase Domain From Mycobacterium Tuberculosis with Sulfate and Zinc at pH 4.00, PDB code: 3mk5:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 3mk5

Go back to Zinc Binding Sites List in 3mk5
Zinc binding site 1 out of 2 in the Crystal Structure of 3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase Domain From Mycobacterium Tuberculosis with Sulfate and Zinc at pH 4.00


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of 3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase Domain From Mycobacterium Tuberculosis with Sulfate and Zinc at pH 4.00 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn210

b:72.4
occ:1.00
 ND1 A:HIS144 2.2 29.5 1.0
O3 A:SO4207 2.6 51.7 1.0
CE1 A:HIS144 3.1 29.5 1.0
O4 A:SO4207 3.2 52.0 1.0
CG A:HIS144 3.3 26.4 1.0
S A:SO4207 3.4 51.3 1.0
CB A:HIS144 3.6 25.0 1.0
O1 A:SO4207 4.1 51.4 1.0
OD1 A:ASP33 4.2 33.0 1.0
NE2 A:HIS144 4.3 29.9 1.0
OD2 A:ASP33 4.3 33.7 1.0
OD1 A:ASP24 4.3 52.9 1.0
CD2 A:HIS144 4.3 28.2 1.0
N A:HIS144 4.5 25.0 1.0
CG A:ASP33 4.5 31.8 1.0
O2 A:SO4207 4.7 49.5 1.0
OD2 A:ASP24 4.7 50.9 1.0
CA A:HIS144 4.7 24.3 1.0
CG A:ASP24 4.8 49.9 1.0

Zinc binding site 2 out of 2 in 3mk5

Go back to Zinc Binding Sites List in 3mk5
Zinc binding site 2 out of 2 in the Crystal Structure of 3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase Domain From Mycobacterium Tuberculosis with Sulfate and Zinc at pH 4.00


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of 3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase Domain From Mycobacterium Tuberculosis with Sulfate and Zinc at pH 4.00 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn211

b:0.2
occ:1.00
 O A:HOH286 2.8 49.6 1.0
ND1 A:HIS188 2.9 32.1 1.0
CE1 A:HIS188 3.8 30.9 1.0
CG A:HIS188 3.9 29.6 1.0
CE1 A:PHE48 4.0 28.4 1.0
O A:HOH305 4.0 53.4 1.0
CB A:HIS188 4.0 29.7 1.0
CD1 A:PHE48 4.2 30.8 1.0
O A:HOH281 4.4 50.4 1.0
CA A:HIS188 4.5 29.3 1.0
CZ A:PHE48 4.9 29.8 1.0
NE2 A:HIS188 5.0 31.2 1.0
O A:HIS188 5.0 29.4 1.0

Reference:

M.Singh, P.Kumar, S.Karthikeyan. Structural Basis For pH Dependent Monomer-Dimer Transition of 3,4-Dihydroxy 2-Butanone-4-Phosphate Synthase Domain From Mycobacterium Tuberculosis J.Struct.Biol. V. 174 374 2011.
ISSN: ISSN 1047-8477
PubMed: 21296160
DOI: 10.1016/J.JSB.2011.01.013
Page generated: Sat Oct 26 09:35:06 2024

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