Zinc in PDB 3mi9: Crystal Structure of Hiv-1 Tat Complexed with Human P-Tefb

All present enzymatic activity of Crystal Structure of Hiv-1 Tat Complexed with Human P-Tefb:
2.7.11.22; 2.7.11.23;

The structure of Crystal Structure of Hiv-1 Tat Complexed with Human P-Tefb, PDB code: 3mi9 was solved by T.H.Tahirov, N.D.Babayeva, K.Varzavand, J.J.Cooper, S.C.Sedore, D.H.Price, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.63 / 2.10
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	132.306, 132.306, 95.358, 90.00, 90.00, 120.00
R / Rfree (%)	21.9 / 26.4

The binding sites of Zinc atom in the Crystal Structure of Hiv-1 Tat Complexed with Human P-Tefb (pdb code 3mi9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Hiv-1 Tat Complexed with Human P-Tefb, PDB code: 3mi9:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Hiv-1 Tat Complexed with Human P-Tefb


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Hiv-1 Tat Complexed with Human P-Tefb within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn87 b:53.1 occ:1.00 ND1 C:HIS33 2.3 50.3 1.0 SG C:CYS37 2.3 52.5 1.0 SG C:CYS22 2.3 61.4 1.0 SG C:CYS34 2.3 44.0 1.0 CG C:HIS33 3.2 54.3 1.0 CE1 C:HIS33 3.3 44.9 1.0 CB C:CYS34 3.3 38.0 1.0 CB C:HIS33 3.4 45.5 1.0 CB C:CYS37 3.4 42.8 1.0 CB C:CYS22 3.5 64.8 1.0 N C:CYS34 3.6 52.6 1.0 C C:HIS33 4.0 50.8 1.0 N C:CYS37 4.1 40.4 1.0 CA C:CYS34 4.1 54.7 1.0 CA C:CYS22 4.1 69.7 1.0 CA C:HIS33 4.3 50.2 1.0 CA C:CYS37 4.3 51.9 1.0 CD2 C:HIS33 4.4 56.7 1.0 NE2 C:HIS33 4.4 56.9 1.0 O C:HIS33 4.6 53.7 1.0 C C:CYS34 4.7 55.0 1.0 CG C:PRO18 4.8 60.6 1.0 O C:CYS34 4.8 57.9 1.0 CB C:PRO18 4.9 59.9 1.0 N C:CYS22 4.9 68.0 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Hiv-1 Tat Complexed with Human P-Tefb


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Hiv-1 Tat Complexed with Human P-Tefb within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn88 b:71.6 occ:1.00 SG C:CYS25 2.3 65.5 1.0 SG C:CYS27 2.3 66.7 1.0 SG C:CYS30 2.3 77.1 1.0 SG B:CYS261 2.3 0.1 1.0 CB C:CYS30 3.3 63.5 1.0 CB C:CYS25 3.3 64.5 1.0 CB C:CYS27 3.7 68.3 1.0 CB B:CYS261 3.9 97.0 1.0 N B:CYS261 3.9 97.2 1.0 N C:CYS30 4.1 69.5 1.0 CA B:CYS261 4.2 0.6 1.0 CA C:CYS30 4.3 70.0 1.0 C B:CYS261 4.3 0.1 1.0 O B:CYS261 4.4 0.8 1.0 N C:CYS27 4.5 71.1 1.0 CA C:CYS25 4.6 72.7 1.0 C C:CYS25 4.6 74.5 1.0 CA C:CYS27 4.6 70.1 1.0 N C:TYR26 4.8 71.7 1.0 C C:TYR26 4.9 66.3 1.0

T.H.Tahirov, N.D.Babayeva, K.Varzavand, J.J.Cooper, S.C.Sedore, D.H.Price. Crystal Structure of Hiv-1 Tat Complexed with Human P-Tefb. Nature V. 465 747 2010.
ISSN: ISSN 0028-0836
PubMed: 20535204
DOI: 10.1038/NATURE09131