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Atomistry » Zinc » PDB 3m6p-3mho » 3mhk » |
Zinc in PDB 3mhk: Human Tankyrase 2 - Catalytic Parp Domain in Complex with 2-(2- Pyridyl)-7,8-Dihydro-5H-Thiino[4,3-D]Pyrimidin-4-OlEnzymatic activity of Human Tankyrase 2 - Catalytic Parp Domain in Complex with 2-(2- Pyridyl)-7,8-Dihydro-5H-Thiino[4,3-D]Pyrimidin-4-Ol
All present enzymatic activity of Human Tankyrase 2 - Catalytic Parp Domain in Complex with 2-(2- Pyridyl)-7,8-Dihydro-5H-Thiino[4,3-D]Pyrimidin-4-Ol:
2.4.2.30; Protein crystallography data
The structure of Human Tankyrase 2 - Catalytic Parp Domain in Complex with 2-(2- Pyridyl)-7,8-Dihydro-5H-Thiino[4,3-D]Pyrimidin-4-Ol, PDB code: 3mhk
was solved by
T.Karlberg,
P.Schutz,
C.H.Arrowsmith,
H.Berglund,
C.Bountra,
R.Collins,
A.M.Edwards,
S.Flodin,
A.Flores,
S.Graslund,
M.Hammarstrom,
I.Johansson,
T.Kotenyova,
N.Markova,
M.Moche,
P.Nordlund,
T.Nyman,
C.Persson,
M.I.Siponen,
L.Svensson,
A.G.Thorsell,
L.Tresaugues,
S.Van Den Berg,
J.Weigelt,
M.Welin,
M.Wisniewska,
H.Schuler,
Structural Genomicsconsortium (Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Human Tankyrase 2 - Catalytic Parp Domain in Complex with 2-(2- Pyridyl)-7,8-Dihydro-5H-Thiino[4,3-D]Pyrimidin-4-Ol
(pdb code 3mhk). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Tankyrase 2 - Catalytic Parp Domain in Complex with 2-(2- Pyridyl)-7,8-Dihydro-5H-Thiino[4,3-D]Pyrimidin-4-Ol, PDB code: 3mhk: Zinc binding site 1 out of 1 in 3mhkGo back to Zinc Binding Sites List in 3mhk
Zinc binding site 1 out
of 1 in the Human Tankyrase 2 - Catalytic Parp Domain in Complex with 2-(2- Pyridyl)-7,8-Dihydro-5H-Thiino[4,3-D]Pyrimidin-4-Ol
Mono view Stereo pair view
Reference:
E.Wahlberg,
T.Karlberg,
E.Kouznetsova,
N.Markova,
A.Macchiarulo,
A.G.Thorsell,
E.Pol,
A.Frostell,
T.Ekblad,
B.Kull,
G.M.Robertson,
R.Pellicciari,
H.Schuler,
J.Weigelt.
Family-Wide Chemical Profiling and Structural Analysis of Parp and Tankyrase Inhibitors Nat.Biotechnol. V. 30 283 2012.
Page generated: Wed Dec 16 04:35:06 2020
ISSN: ISSN 1087-0156 PubMed: 22343925 DOI: 10.1038/NBT.2121 |
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