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Atomistry » Zinc » PDB 3m6p-3mho » 3mhj | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 3m6p-3mho » 3mhj » |
Zinc in PDB 3mhj: Human Tankyrase 2 - Catalytic Parp Domain in Complex with 1-Methyl-3- (Trifluoromethyl)-5H-Benzo[C][1,8]Naphtyridine-6-OneEnzymatic activity of Human Tankyrase 2 - Catalytic Parp Domain in Complex with 1-Methyl-3- (Trifluoromethyl)-5H-Benzo[C][1,8]Naphtyridine-6-One
All present enzymatic activity of Human Tankyrase 2 - Catalytic Parp Domain in Complex with 1-Methyl-3- (Trifluoromethyl)-5H-Benzo[C][1,8]Naphtyridine-6-One:
2.4.2.30; Protein crystallography data
The structure of Human Tankyrase 2 - Catalytic Parp Domain in Complex with 1-Methyl-3- (Trifluoromethyl)-5H-Benzo[C][1,8]Naphtyridine-6-One, PDB code: 3mhj
was solved by
T.Karlberg,
P.Schutz,
C.H.Arrowsmith,
H.Berglund,
C.Bountra,
R.Collins,
A.M.Edwards,
S.Flodin,
A.Flores,
S.Graslund,
M.Hammarstrom,
I.Johansson,
T.Kotenyova,
N.Markova,
M.Moche,
P.Nordlund,
T.Nyman,
C.Persson,
M.I.Siponen,
L.Svensson,
A.G.Thorsell,
L.Tresaugues,
S.Van Den Berg,
J.Weigelt,
M.Welin,
M.Wisniewska,
H.Schuler,
Structural Genomicsconsortium (Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3mhj:
The structure of Human Tankyrase 2 - Catalytic Parp Domain in Complex with 1-Methyl-3- (Trifluoromethyl)-5H-Benzo[C][1,8]Naphtyridine-6-One also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Human Tankyrase 2 - Catalytic Parp Domain in Complex with 1-Methyl-3- (Trifluoromethyl)-5H-Benzo[C][1,8]Naphtyridine-6-One
(pdb code 3mhj). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human Tankyrase 2 - Catalytic Parp Domain in Complex with 1-Methyl-3- (Trifluoromethyl)-5H-Benzo[C][1,8]Naphtyridine-6-One, PDB code: 3mhj: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 3mhjGo back to Zinc Binding Sites List in 3mhj
Zinc binding site 1 out
of 2 in the Human Tankyrase 2 - Catalytic Parp Domain in Complex with 1-Methyl-3- (Trifluoromethyl)-5H-Benzo[C][1,8]Naphtyridine-6-One
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 3mhjGo back to Zinc Binding Sites List in 3mhj
Zinc binding site 2 out
of 2 in the Human Tankyrase 2 - Catalytic Parp Domain in Complex with 1-Methyl-3- (Trifluoromethyl)-5H-Benzo[C][1,8]Naphtyridine-6-One
Mono view Stereo pair view
Reference:
E.Wahlberg,
T.Karlberg,
E.Kouznetsova,
N.Markova,
A.Macchiarulo,
A.G.Thorsell,
E.Pol,
A.Frostell,
T.Ekblad,
B.Kull,
G.M.Robertson,
R.Pellicciari,
H.Schuler,
J.Weigelt.
Family-Wide Chemical Profiling and Structural Analysis of Parp and Tankyrase Inhibitors Nat.Biotechnol. V. 30 283 2012.
Page generated: Wed Dec 16 04:35:04 2020
ISSN: ISSN 1087-0156 PubMed: 22343925 DOI: 10.1038/NBT.2121 |
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