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Zinc in PDB 3lms: Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci.

Enzymatic activity of Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci.

All present enzymatic activity of Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci.:
3.4.17.20;

Protein crystallography data

The structure of Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci., PDB code: 3lms was solved by L.Sanglas, J.L.Arolas, Z.Valnickova, F.X.Aviles, J.J.Enghild, F.X.Gomis-Ruth, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.18 / 2.50
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 157.180, 157.180, 57.070, 90.00, 90.00, 120.00
R / Rfree (%) 18.5 / 21.6

Other elements in 3lms:

The structure of Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci. also contains other interesting chemical elements:

Potassium (K) 2 atoms
Chlorine (Cl) 3 atoms
Calcium (Ca) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci. (pdb code 3lms). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci., PDB code: 3lms:

Zinc binding site 1 out of 1 in 3lms

Go back to Zinc Binding Sites List in 3lms
Zinc binding site 1 out of 1 in the Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn309

b:42.6
occ:1.00
 ND1 A:HIS69 2.1 41.4 1.0
ND1 A:HIS196 2.1 42.6 1.0
OXT B:LEU74 2.1 49.3 1.0
OE2 A:GLU72 2.3 40.6 1.0
O B:LEU74 2.4 46.3 1.0
OE1 A:GLU72 2.4 41.3 1.0
C B:LEU74 2.6 46.6 1.0
CD A:GLU72 2.7 41.7 1.0
CE1 A:HIS69 2.9 40.5 1.0
CG A:HIS196 3.1 43.1 1.0
CE1 A:HIS196 3.1 43.8 1.0
CG A:HIS69 3.2 41.0 1.0
CB A:HIS196 3.4 42.1 1.0
CB A:HIS69 3.7 41.5 1.0
CA B:LEU74 4.0 46.0 1.0
NE2 A:HIS69 4.1 40.4 1.0
O A:HOH512 4.2 47.3 1.0
CG A:GLU72 4.2 42.4 1.0
NE2 A:HIS196 4.2 42.6 1.0
CD2 A:HIS196 4.2 44.5 1.0
CD2 A:HIS69 4.3 39.4 1.0
NH1 A:ARG127 4.3 42.7 1.0
O A:HOH513 4.3 40.4 1.0
O A:SER197 4.3 43.5 1.0
CA A:HIS196 4.3 42.9 1.0
N A:SER197 4.7 43.7 1.0
CA A:GLY501 4.7 47.9 1.0
C A:GLY501 4.8 46.4 1.0
OE1 A:GLU270 4.9 52.9 1.0
O A:GLY501 4.9 44.2 1.0
CB B:LEU74 4.9 47.3 1.0
N B:LEU74 4.9 43.3 1.0
N A:HIS69 4.9 41.3 1.0
CA A:HIS69 4.9 41.0 1.0

Reference:

L.Sanglas, J.L.Arolas, Z.Valnickova, F.X.Aviles, J.J.Enghild, F.X.Gomis-Ruth. Insights Into the Molecular Inactivation Mechanism of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor J.Thromb.Haemost. V. 8 1056 2010.
ISSN: ISSN 1538-7933
PubMed: 20088943
DOI: 10.1111/J.1538-7836.2010.03740.X
Page generated: Sat Oct 26 08:43:39 2024

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