Atomistry » Zinc » PDB 3l2r-3ljg » 3lgg
Atomistry »
  Zinc »
    PDB 3l2r-3ljg »
      3lgg »

Zinc in PDB 3lgg: Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin

Enzymatic activity of Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin

All present enzymatic activity of Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin:
3.5.4.4;

Protein crystallography data

The structure of Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin, PDB code: 3lgg was solved by A.V.Zavialov, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 66.82 / 2.50
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 63.249, 72.993, 80.537, 113.55, 94.89, 91.53
R / Rfree (%) 19.2 / 22.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin (pdb code 3lgg). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin, PDB code: 3lgg:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 3lgg

Go back to Zinc Binding Sites List in 3lgg
Zinc binding site 1 out of 2 in the Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn512

b:42.5
occ:1.00
O8 A:CFE513 1.9 33.6 1.0
NE2 A:HIS88 2.2 30.8 1.0
NE2 A:HIS86 2.2 26.6 1.0
NE2 A:HIS330 2.3 22.0 1.0
OD1 A:ASP415 2.5 27.1 1.0
CD2 A:HIS86 3.0 26.5 1.0
C8 A:CFE513 3.1 31.6 1.0
CD2 A:HIS88 3.1 30.3 1.0
CE1 A:HIS330 3.1 22.2 1.0
CE1 A:HIS88 3.2 30.1 1.0
CE1 A:HIS86 3.3 26.5 1.0
CG A:ASP415 3.3 25.5 1.0
CD2 A:HIS330 3.4 21.2 1.0
C9 A:CFE513 3.4 31.1 1.0
OD2 A:ASP415 3.5 25.7 1.0
NE2 A:HIS358 3.6 19.6 1.0
N1 A:CFE513 4.0 30.3 1.0
C10 A:CFE513 4.1 31.5 1.0
C7 A:CFE513 4.2 31.4 1.0
CG A:HIS86 4.3 25.6 1.0
ND1 A:HIS330 4.3 23.1 1.0
CG A:HIS88 4.3 29.5 1.0
ND1 A:HIS88 4.3 30.5 1.0
ND1 A:HIS86 4.3 26.2 1.0
N4 A:CFE513 4.4 30.9 1.0
CG A:HIS330 4.4 22.1 1.0
N6 A:CFE513 4.4 31.3 1.0
CD2 A:HIS358 4.5 19.5 1.0
C5 A:CFE513 4.5 30.8 1.0
CE1 A:HIS358 4.6 19.2 1.0
CB A:ASP415 4.7 24.7 1.0
C2 A:CFE513 4.8 30.9 1.0
N3 A:CFE513 4.9 31.7 1.0
OD2 A:ASP416 4.9 29.9 1.0

Zinc binding site 2 out of 2 in 3lgg

Go back to Zinc Binding Sites List in 3lgg
Zinc binding site 2 out of 2 in the Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn512

b:45.3
occ:1.00
O8 B:CFE513 1.9 33.1 1.0
NE2 B:HIS86 2.1 27.1 1.0
NE2 B:HIS88 2.2 30.7 1.0
NE2 B:HIS330 2.3 22.1 1.0
OD1 B:ASP415 2.6 26.9 1.0
CD2 B:HIS86 2.9 26.6 1.0
C8 B:CFE513 3.1 33.2 1.0
CE1 B:HIS330 3.1 22.4 1.0
CD2 B:HIS88 3.1 30.2 1.0
CE1 B:HIS88 3.2 30.1 1.0
CE1 B:HIS86 3.2 26.6 1.0
CD2 B:HIS330 3.4 21.3 1.0
C9 B:CFE513 3.4 33.6 1.0
CG B:ASP415 3.4 25.6 1.0
OD2 B:ASP415 3.6 26.0 1.0
NE2 B:HIS358 3.7 19.8 1.0
C10 B:CFE513 4.0 34.8 1.0
N1 B:CFE513 4.0 34.0 1.0
CG B:HIS86 4.1 25.5 1.0
ND1 B:HIS86 4.2 26.1 1.0
C7 B:CFE513 4.2 33.6 1.0
ND1 B:HIS88 4.3 30.6 1.0
ND1 B:HIS330 4.3 23.0 1.0
CG B:HIS88 4.3 29.6 1.0
N4 B:CFE513 4.3 34.7 1.0
N6 B:CFE513 4.4 34.7 1.0
CG B:HIS330 4.4 22.0 1.0
C5 B:CFE513 4.5 34.4 1.0
CD2 B:HIS358 4.5 19.2 1.0
CE1 B:HIS358 4.6 19.3 1.0
CB B:ASP415 4.7 24.6 1.0
C2 B:CFE513 4.8 33.0 1.0
N3 B:CFE513 4.8 34.3 1.0
OD2 B:ASP416 4.9 29.9 1.0

Reference:

A.V.Zavialov, X.Yu, D.Spillmann, G.Lauvau, A.V.Zavialov. Structural Basis For the Growth Factor Activity of Human Adenosine Deaminase ADA2. J.Biol.Chem. V. 285 12367 2010.
ISSN: ISSN 0021-9258
PubMed: 20147294
DOI: 10.1074/JBC.M109.083527
Page generated: Sat Oct 26 08:31:33 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy