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Zinc in PDB 3lgg: Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin

Enzymatic activity of Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin

All present enzymatic activity of Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin:
3.5.4.4;

Protein crystallography data

The structure of Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin, PDB code: 3lgg was solved by A.V.Zavialov, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 66.82 / 2.50
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 63.249, 72.993, 80.537, 113.55, 94.89, 91.53
R / Rfree (%) 19.2 / 22.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin (pdb code 3lgg). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin, PDB code: 3lgg:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 3lgg

Go back to Zinc Binding Sites List in 3lgg
Zinc binding site 1 out of 2 in the Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn512

b:42.5
occ:1.00
 O8 A:CFE513 1.9 33.6 1.0
NE2 A:HIS88 2.2 30.8 1.0
NE2 A:HIS86 2.2 26.6 1.0
NE2 A:HIS330 2.3 22.0 1.0
OD1 A:ASP415 2.5 27.1 1.0
CD2 A:HIS86 3.0 26.5 1.0
C8 A:CFE513 3.1 31.6 1.0
CD2 A:HIS88 3.1 30.3 1.0
CE1 A:HIS330 3.1 22.2 1.0
CE1 A:HIS88 3.2 30.1 1.0
CE1 A:HIS86 3.3 26.5 1.0
CG A:ASP415 3.3 25.5 1.0
CD2 A:HIS330 3.4 21.2 1.0
C9 A:CFE513 3.4 31.1 1.0
OD2 A:ASP415 3.5 25.7 1.0
NE2 A:HIS358 3.6 19.6 1.0
N1 A:CFE513 4.0 30.3 1.0
C10 A:CFE513 4.1 31.5 1.0
C7 A:CFE513 4.2 31.4 1.0
CG A:HIS86 4.3 25.6 1.0
ND1 A:HIS330 4.3 23.1 1.0
CG A:HIS88 4.3 29.5 1.0
ND1 A:HIS88 4.3 30.5 1.0
ND1 A:HIS86 4.3 26.2 1.0
N4 A:CFE513 4.4 30.9 1.0
CG A:HIS330 4.4 22.1 1.0
N6 A:CFE513 4.4 31.3 1.0
CD2 A:HIS358 4.5 19.5 1.0
C5 A:CFE513 4.5 30.8 1.0
CE1 A:HIS358 4.6 19.2 1.0
CB A:ASP415 4.7 24.7 1.0
C2 A:CFE513 4.8 30.9 1.0
N3 A:CFE513 4.9 31.7 1.0
OD2 A:ASP416 4.9 29.9 1.0

Zinc binding site 2 out of 2 in 3lgg

Go back to Zinc Binding Sites List in 3lgg
Zinc binding site 2 out of 2 in the Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) Complexed with Transition State Analogue, Coformycin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn512

b:45.3
occ:1.00
 O8 B:CFE513 1.9 33.1 1.0
NE2 B:HIS86 2.1 27.1 1.0
NE2 B:HIS88 2.2 30.7 1.0
NE2 B:HIS330 2.3 22.1 1.0
OD1 B:ASP415 2.6 26.9 1.0
CD2 B:HIS86 2.9 26.6 1.0
C8 B:CFE513 3.1 33.2 1.0
CE1 B:HIS330 3.1 22.4 1.0
CD2 B:HIS88 3.1 30.2 1.0
CE1 B:HIS88 3.2 30.1 1.0
CE1 B:HIS86 3.2 26.6 1.0
CD2 B:HIS330 3.4 21.3 1.0
C9 B:CFE513 3.4 33.6 1.0
CG B:ASP415 3.4 25.6 1.0
OD2 B:ASP415 3.6 26.0 1.0
NE2 B:HIS358 3.7 19.8 1.0
C10 B:CFE513 4.0 34.8 1.0
N1 B:CFE513 4.0 34.0 1.0
CG B:HIS86 4.1 25.5 1.0
ND1 B:HIS86 4.2 26.1 1.0
C7 B:CFE513 4.2 33.6 1.0
ND1 B:HIS88 4.3 30.6 1.0
ND1 B:HIS330 4.3 23.0 1.0
CG B:HIS88 4.3 29.6 1.0
N4 B:CFE513 4.3 34.7 1.0
N6 B:CFE513 4.4 34.7 1.0
CG B:HIS330 4.4 22.0 1.0
C5 B:CFE513 4.5 34.4 1.0
CD2 B:HIS358 4.5 19.2 1.0
CE1 B:HIS358 4.6 19.3 1.0
CB B:ASP415 4.7 24.6 1.0
C2 B:CFE513 4.8 33.0 1.0
N3 B:CFE513 4.8 34.3 1.0
OD2 B:ASP416 4.9 29.9 1.0

Reference:

A.V.Zavialov, X.Yu, D.Spillmann, G.Lauvau, A.V.Zavialov. Structural Basis For the Growth Factor Activity of Human Adenosine Deaminase ADA2. J.Biol.Chem. V. 285 12367 2010.
ISSN: ISSN 0021-9258
PubMed: 20147294
DOI: 10.1074/JBC.M109.083527
Page generated: Sat Oct 26 08:31:33 2024

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