Zinc in PDB 3lgd: Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2)

All present enzymatic activity of Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2):
3.5.4.4;

The structure of Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2), PDB code: 3lgd was solved by A.V.Zavialov, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.68 / 2.00
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	63.212, 73.099, 80.662, 113.38, 94.18, 92.16
R / Rfree (%)	18.5 / 23.4

The binding sites of Zinc atom in the Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) (pdb code 3lgd). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2), PDB code: 3lgd:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn850 b:30.7 occ:1.00 NE2 A:HIS88 2.1 26.9 1.0 NE2 A:HIS86 2.2 23.6 1.0 NE2 A:HIS330 2.3 18.4 1.0 OD1 A:ASP415 2.6 27.9 1.0 CD2 A:HIS86 3.0 23.3 1.0 UNK A:UNX951 3.0 25.0 1.0 CE1 A:HIS330 3.1 20.6 1.0 CE1 A:HIS88 3.1 26.8 1.0 CD2 A:HIS88 3.2 26.0 1.0 CG A:ASP415 3.3 25.4 1.0 CE1 A:HIS86 3.3 22.2 1.0 CD2 A:HIS330 3.3 19.6 1.0 OD2 A:ASP415 3.5 29.3 1.0 NE2 A:HIS358 3.7 16.4 1.0 O A:HOH509 4.2 30.2 1.0 ND1 A:HIS88 4.2 26.4 1.0 ND1 A:HIS330 4.2 19.7 1.0 CG A:HIS86 4.3 19.9 1.0 CG A:HIS88 4.3 25.0 1.0 ND1 A:HIS86 4.3 22.5 1.0 CG A:HIS330 4.4 19.3 1.0 CD2 A:HIS358 4.5 16.4 1.0 CB A:ASP415 4.5 22.5 1.0 CE1 A:HIS358 4.6 15.3 1.0 O A:HOH512 4.8 13.1 1.0 CA A:ASP415 5.0 22.1 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Adenosine Deaminase Growth Factor, Adenosine Deaminase Type 2 (ADA2) within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn850 b:30.9 occ:1.00 NE2 B:HIS88 2.2 28.6 1.0 NE2 B:HIS330 2.2 18.9 1.0 NE2 B:HIS86 2.2 24.7 1.0 OD1 B:ASP415 2.3 28.2 1.0 CD2 B:HIS88 3.0 26.1 1.0 CE1 B:HIS330 3.0 19.4 1.0 UNK B:UNX951 3.1 29.3 1.0 CD2 B:HIS86 3.2 21.3 1.0 CE1 B:HIS86 3.2 21.0 1.0 CG B:ASP415 3.3 26.1 1.0 CD2 B:HIS330 3.3 19.4 1.0 CE1 B:HIS88 3.3 27.3 1.0 OD2 B:ASP415 3.6 30.3 1.0 NE2 B:HIS358 3.8 16.1 1.0 ND1 B:HIS330 4.2 18.4 1.0 CG B:HIS88 4.2 24.7 1.0 ND1 B:HIS88 4.3 25.9 1.0 CG B:HIS86 4.3 20.0 1.0 ND1 B:HIS86 4.3 22.9 1.0 CG B:HIS330 4.3 19.4 1.0 O B:HOH510 4.4 35.4 1.0 CD2 B:HIS358 4.5 15.9 1.0 CB B:ASP415 4.6 21.7 1.0 O B:HOH511 4.6 18.2 1.0 CE1 B:HIS358 4.7 15.2 1.0 CA B:ASP415 5.0 21.5 1.0

A.V.Zavialov, X.Yu, D.Spillmann, G.Lauvau, A.V.Zavialov. Structural Basis For the Growth Factor Activity of Human Adenosine Deaminase ADA2. J.Biol.Chem. V. 285 12367 2010.
ISSN: ISSN 0021-9258
PubMed: 20147294
DOI: 10.1074/JBC.M109.083527