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Atomistry » Zinc » PDB 3jpy-3jyg » 3jsw | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 3jpy-3jyg » 3jsw » |
Zinc in PDB 3jsw: Human PDE9 in Complex with Selective InhibitorEnzymatic activity of Human PDE9 in Complex with Selective Inhibitor
All present enzymatic activity of Human PDE9 in Complex with Selective Inhibitor:
3.1.4.35; Protein crystallography data
The structure of Human PDE9 in Complex with Selective Inhibitor, PDB code: 3jsw
was solved by
S.Liu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3jsw:
The structure of Human PDE9 in Complex with Selective Inhibitor also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Human PDE9 in Complex with Selective Inhibitor
(pdb code 3jsw). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human PDE9 in Complex with Selective Inhibitor, PDB code: 3jsw: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 3jswGo back to Zinc Binding Sites List in 3jsw
Zinc binding site 1 out
of 2 in the Human PDE9 in Complex with Selective Inhibitor
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 3jswGo back to Zinc Binding Sites List in 3jsw
Zinc binding site 2 out
of 2 in the Human PDE9 in Complex with Selective Inhibitor
Mono view Stereo pair view
Reference:
P.R.Verhoest,
C.Proulx-Lafrance,
M.Corman,
L.Chenard,
C.J.Helal,
X.Hou,
R.Kleiman,
S.Liu,
E.Marr,
F.S.Menniti,
C.J.Schmidt,
M.Vanase-Frawley,
A.W.Schmidt,
R.D.Williams,
F.R.Nelson,
K.R.Fonseca,
S.Liras.
Identification of A Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement As A Rapid Lead Optimization Strategy. J.Med.Chem. V. 52 7946 2009.
Page generated: Wed Dec 16 04:28:34 2020
ISSN: ISSN 0022-2623 PubMed: 19919087 DOI: 10.1021/JM9015334 |
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