Zinc in PDB 3jr3: SIR2 Bound to Acetylated Peptide

The structure of SIR2 Bound to Acetylated Peptide, PDB code: 3jr3 was solved by W.F.Hawse, C.Wolberger, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	22.55 / 1.50
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	45.717, 58.382, 106.516, 90.00, 90.00, 90.00
R / Rfree (%)	20.5 / 22.8

The binding sites of Zinc atom in the SIR2 Bound to Acetylated Peptide (pdb code 3jr3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the SIR2 Bound to Acetylated Peptide, PDB code: 3jr3:

Zinc binding site 1 out of 1 in the SIR2 Bound to Acetylated Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of SIR2 Bound to Acetylated Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:27.5 occ:1.00 SG A:CYS127 2.3 30.4 1.0 SG A:CYS148 2.3 28.4 1.0 SG A:CYS124 2.4 23.7 1.0 SG A:CYS151 2.4 28.9 1.0 CB A:CYS148 3.1 27.9 1.0 CB A:CYS124 3.1 23.3 1.0 CB A:CYS127 3.4 28.8 1.0 CB A:CYS151 3.6 29.7 1.0 N A:CYS127 3.8 28.0 1.0 N A:CYS151 3.8 30.8 1.0 CA A:CYS127 4.1 28.8 1.0 CA A:CYS151 4.2 29.8 1.0 CB A:ASP150 4.5 32.5 1.0 CA A:CYS148 4.6 28.1 1.0 CA A:CYS124 4.6 23.5 1.0 CB A:SER153 4.7 26.8 1.0 O A:HOH375 4.7 40.9 1.0 C A:ASP150 4.7 32.0 1.0 C A:CYS151 4.8 29.8 1.0 CB A:LYS129 4.8 27.6 1.0 CB A:ARG126 4.8 27.7 1.0 C A:CYS127 4.8 28.8 1.0 N A:SER153 4.8 27.0 1.0 N A:GLU128 4.9 28.9 1.0 N A:ASN152 4.9 29.2 1.0 C A:ARG126 4.9 27.7 1.0 CA A:ASP150 5.0 31.8 1.0 N A:ASP150 5.0 32.0 1.0

W.F.Hawse, C.Wolberger. Structure-Based Mechanism of Adp-Ribosylation By Sirtuins. J.Biol.Chem. V. 284 33654 2009.
ISSN: ISSN 0021-9258
PubMed: 19801667
DOI: 10.1074/JBC.M109.024521