Atomistry » Zinc » PDB 3eb6-3ejt » 3ejs
Atomistry »
  Zinc »
    PDB 3eb6-3ejt »
      3ejs »

Zinc in PDB 3ejs: Golgi Alpha-Mannosidase II in Complex with 5-Substituted Swainsonine Analog: (5S)-5-[2'-(4-Tert-Butylphenyl)Ethyl]-Swainsonine

Enzymatic activity of Golgi Alpha-Mannosidase II in Complex with 5-Substituted Swainsonine Analog: (5S)-5-[2'-(4-Tert-Butylphenyl)Ethyl]-Swainsonine

All present enzymatic activity of Golgi Alpha-Mannosidase II in Complex with 5-Substituted Swainsonine Analog: (5S)-5-[2'-(4-Tert-Butylphenyl)Ethyl]-Swainsonine:
3.2.1.114;

Protein crystallography data

The structure of Golgi Alpha-Mannosidase II in Complex with 5-Substituted Swainsonine Analog: (5S)-5-[2'-(4-Tert-Butylphenyl)Ethyl]-Swainsonine, PDB code: 3ejs was solved by D.A.Kuntz, K.Shea, D.R.Rose, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.54 / 1.35
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 69.343, 110.425, 139.857, 90.00, 90.00, 90.00
R / Rfree (%) 19.1 / 21.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Golgi Alpha-Mannosidase II in Complex with 5-Substituted Swainsonine Analog: (5S)-5-[2'-(4-Tert-Butylphenyl)Ethyl]-Swainsonine (pdb code 3ejs). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Alpha-Mannosidase II in Complex with 5-Substituted Swainsonine Analog: (5S)-5-[2'-(4-Tert-Butylphenyl)Ethyl]-Swainsonine, PDB code: 3ejs:

Zinc binding site 1 out of 1 in 3ejs

Go back to Zinc Binding Sites List in 3ejs
Zinc binding site 1 out of 1 in the Golgi Alpha-Mannosidase II in Complex with 5-Substituted Swainsonine Analog: (5S)-5-[2'-(4-Tert-Butylphenyl)Ethyl]-Swainsonine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Golgi Alpha-Mannosidase II in Complex with 5-Substituted Swainsonine Analog: (5S)-5-[2'-(4-Tert-Butylphenyl)Ethyl]-Swainsonine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1047

b:7.6
occ:1.00
 NE2 A:HIS471 2.1 6.4 1.0
NE2 A:HIS90 2.2 6.7 1.0
O2 A:HN51049 2.2 8.7 1.0
OD2 A:ASP204 2.2 7.9 1.0
O1 A:HN51049 2.2 8.0 1.0
OD1 A:ASP92 2.2 8.5 1.0
CD2 A:HIS90 3.1 7.4 1.0
CD2 A:HIS471 3.1 6.5 1.0
CE1 A:HIS471 3.1 6.3 1.0
C1 A:HN51049 3.1 9.0 1.0
C2 A:HN51049 3.1 7.7 1.0
CG A:ASP204 3.2 8.3 1.0
CE1 A:HIS90 3.2 7.7 1.0
CG A:ASP92 3.2 9.7 1.0
OD2 A:ASP92 3.5 10.5 1.0
CB A:ASP204 3.5 8.5 1.0
C3 A:HN51049 4.0 9.1 1.0
N4 A:HN51049 4.0 7.7 1.0
C8A A:HN51049 4.1 9.3 1.0
OD2 A:ASP472 4.2 6.7 1.0
CG A:HIS90 4.2 7.6 1.0
ND1 A:HIS471 4.3 6.9 1.0
OD1 A:ASP204 4.3 8.4 1.0
ND1 A:HIS90 4.3 6.8 1.0
CG A:HIS471 4.3 5.8 1.0
CB A:ASP92 4.5 8.0 1.0
CE1 A:HIS470 4.5 8.1 1.0
C8 A:HN51049 4.6 8.1 1.0
O A:HOH1983 4.6 11.1 1.0
OH A:TYR269 4.8 10.7 1.0

Reference:

D.A.Kuntz, S.Nakayama, K.Shea, H.Hori, Y.Uto, H.Nagasawa, D.R.Rose. Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi Alpha-Mannosidase II. Chembiochem V. 11 673 2010.
ISSN: ISSN 1439-4227
PubMed: 20209559
DOI: 10.1002/CBIC.200900750
Page generated: Wed Dec 16 04:16:24 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy