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Atomistry » Zinc » PDB 3d7h-3dgd » 3ddf » |
Zinc in PDB 3ddf: Golgi Mannosidase II Complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)- 2-Hydroxy-1 Phenylethyl]Amino}Methyl) Pyrrolidin-2-OneEnzymatic activity of Golgi Mannosidase II Complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)- 2-Hydroxy-1 Phenylethyl]Amino}Methyl) Pyrrolidin-2-One
All present enzymatic activity of Golgi Mannosidase II Complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)- 2-Hydroxy-1 Phenylethyl]Amino}Methyl) Pyrrolidin-2-One:
3.2.1.114; Protein crystallography data
The structure of Golgi Mannosidase II Complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)- 2-Hydroxy-1 Phenylethyl]Amino}Methyl) Pyrrolidin-2-One, PDB code: 3ddf
was solved by
D.A.Kuntz,
D.R.Rose,
D.Hoffman,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Golgi Mannosidase II Complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)- 2-Hydroxy-1 Phenylethyl]Amino}Methyl) Pyrrolidin-2-One
(pdb code 3ddf). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Mannosidase II Complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)- 2-Hydroxy-1 Phenylethyl]Amino}Methyl) Pyrrolidin-2-One, PDB code: 3ddf: Zinc binding site 1 out of 1 in 3ddfGo back to Zinc Binding Sites List in 3ddf
Zinc binding site 1 out
of 1 in the Golgi Mannosidase II Complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)- 2-Hydroxy-1 Phenylethyl]Amino}Methyl) Pyrrolidin-2-One
Mono view Stereo pair view
Reference:
H.Fiaux,
D.A.Kuntz,
D.Hoffman,
R.C.Janzer,
S.Gerber-Lemaire,
D.R.Rose,
L.Juillerat-Jeanneret.
Functionalized Pyrrolidine Inhibitors of Human Type II Alpha-Mannosidases As Anti-Cancer Agents: Optimizing the Fit to the Active Site Bioorg.Med.Chem. V. 16 7337 2008.
Page generated: Wed Dec 16 04:12:53 2020
ISSN: ISSN 0968-0896 PubMed: 18599296 DOI: 10.1016/J.BMC.2008.06.021 |
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